226 results about "Brain Part" patented technology

A NIRS sensor device for brain monitoring is small in size, provides reliable attachment to a patient, blocks ambient light, is easy to use, is hygienic, and supports data integration with surgical and monitoring systems. The sensor device is coupled to a remote near infrared light source via a hybrid cable. Since the light source is remotely located, a source adapted for providing high energy, short pulses can easily be used so that there is less chance of interference by superficial non-brain tissues and less interference from ambient light. In addition, the remote location avoids changes in output of local light sources experienced in the prior art during hypothermia procedures (e.g., bandwidth shifts in LEDs as a result of lowered temperature). The higher energy may be achieved by the use of laser diodes as opposed to locally-mounted LEDs typically used in the prior art. The sensor device is a two-piece design comprising a reusable portion containing the photodetector(s) and a disposable portion that receives the light from the reusable portion and bends it to direct the light into the brain.

A method of treating a brain disorder by heat transfer from brain tissue comprising the steps of surgically cutting a heat transfer aperture into a patient's skull, thereby exposing a predetermined portion of patient's brain; surgically implanting into said heat transfer aperture a heat pump having one or more electrical sensor elements and one or more temperature sensor elements; surgically implanting a heat transfer management unit in a body cavity of said patient such that a micro controller of the heat transfer management unit is connected to one or more activity sensor elements and one or more temperature sensor elements contacting brain tissue and connecting the heat transfer management unit to said heat pump via a lead bundle. Optionally, the heat transfer unit may be located external to the patient's body. Responsive to signals from one or more activity or temperature sensor elements, mathematical algorithms of the heat transfer management unit determine abnormal brain activity, causing the heat pump to remove heat from the brain tissue into a heat sink, thereby cooling the predetermined portion of the patient's brain. This technique utilizes acute hypothermia by means of a Peltier cooler or similar device to cool the brain temperature to reduce or prevent seizure initiation and / or propagation. The method may be used in association with brain stimulation and / or drug application to acutely avoid the occurrence of a seizure episode.

The invention relates to a method for stimulating specific areas of a brain using an induction device, comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the induction device; and arranging the induction device relative to the head such that a specific area of the brain determined by means of the simulation model of the induction device is stimulated by a current flowing in the induction device, as well as to a method for stimulating specific areas of a brain using an induction device, comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the head; and arranging the induction device relative to the head such that a specific area of the brain determined by means of the simulation model of the head is stimulated by a current flowing in the induction device, as well as to a device for stimulating specific areas of a brain using an induction device connected to a marker.

Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient. The apparatus may include a blood channeling sleeve that directs body fluid over a heat exchanger where the body fluid's temperature is altered, and then is discharged out the distal end of the sleeve to a desired location, for example, cooled blood to the brain for neuroprotection. The catheter may be used alone or in conjunction with other heat exchangers to cool one region of a patient's body while heating another.

A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation.

The invention provides a nano artificial dura mater capable of being used as a medicine sustained-release system, having the structure which comprises at least two layers, i.e. a hydrophobic anti-blocking electro-spun layer which faces the cerebrum, and a hydrophilic nano cytoskeleton layer which backs on to the cerebrum; and cell factors and / or medicines are arranged in any layer of the artificial dura mater by way of blended spinning. The invention also provides a method for preparing the nano biomimic artificial dura mater. Compared with an artificial mater prepared by the single utilization of the electro-spinning technology, the artificial mater to which the medicines and the cell factors are added by blending technology can effectively prevent infection and faster promote the regeneration process of the artificial mater. The invention also provides a novel medicine loading and releasing mode for treating cerebral diseases, the loaded medicines can be directly and efficiently transferred into the cranial cavity along with the implantation of the dura mate and can be released according to requirements, and therefore the invention realizes favorable treatment effect and has broad application prospect.

A neurotrophic factor production promoting device is provided, which is able to promote production of a neurotrophic factor or neurotrophic factor-like substance in an affected area by a simple technique that, regardless of the place of treatment, can be performed without transplantation of cells or injection into the affected area, in order to prevent or treat various diseases such as brain diseases. In order to apply a high frequency alternating magnetic field in the range of 20 MHz to 180 MHz, 280 MHz to 600 MHz, or 700 MHz to 1000 MHz to cells at a magnetic flux density of no more than 0.01 Tesla, the neurotrophic factor production promoting device includes a high frequency electromagnetic wave generating means generating a high frequency electromagnetic wave of the abovementioned frequency, in which the magnetic stimulation by the high frequency alternating electromagnetic field of the abovementioned high frequency allows the intracellular concentration of calcium ions to be increased so that exocytosis of the neurotrophic factor group is induced, and the magnetic stimulation allows messenger ribonucleic acid (mRNA) of the neurotrophic factor group to be increased in the cells so that the synthesis and extracellular release of the neurotrophic factor group are promoted.

Deep brain electrodes are remotely sensed and activated by means of a remote active implantable medical device (AIMD). In a preferred form, a pulse generator is implanted in the pectoral region and includes a hermetic seal through which protrudes a conductive leadwire which provides an external antenna for transmission and reception of radio frequency (RF) pulses. One or more deep brain electrode modules are constructed and placed which can transmit and receive RF energy from the pulse generator. An RF telemetry link is established between the implanted pulse generator and the deep brain electrode assemblies. The satellite modules are configured for generating pacing pulses for a variety of disease conditions, including epileptic seizures, Turrets Syndrome, Parkinson's Tremor, and a variety of other neurological or brain disorders.

The invention discloses a system for detecting and positioning a brain stimulation target point. The system comprises an induction unit, a signal collecting and recording unit, a signal analyzing and processing unit and an information merging unit. The induction unit is used for inducing an examined person to move autonomously and at least one brain function state in the feeling or emotion so that the brain of the examined person can generate a brain physiological signal. The signal collecting and recording unit is arranged on the brain of the examined person and comprises a physiological signal sensor sensing the brain physiological signal, a front-end collector electrically connected with the physiological signal sensor and used for recording collected data, a microcontroller receiving the brain physiological signal output by the front-end collector, and a signal transmission communication module electrically connected with the microcontroller and used for outputting the signal. The signal analyzing and processing unit receives the brain physiological signal, processes and analyzes the brain physiological signal and outputs a quantitative result of the most obvious responding position (the target point) of the brain physiological signal. The information merging unit is used for conducting image merging of the quantitative result and an image of the brain of the examined person through a display module. According to the scheme, the target point position in deep brain stimulation can be effectively and quantitatively positioned.

The invention relates to a stable preparation of phosphatidylserine and a preparation method, application as well as an application product of the stable preparation. The preparation method comprises the following step of processing the phosphatidylserine through microencapsulation, micro-pelletization or liposome encapsulation. The stable preparation of the phosphatidylserine can be independently applied as a medicine or can be added into daily foods, drinks and health-care products, also has an important effect on health care of brains while guaranteeing the color and the taste of the daily foods and the drinks of people and is of great benefit to brain disorder such as nutritional supplement of brain development of students, overstrain of nerves of the adults, and memory loss, brain atrophy and senile dementia of the middle aged and elderly people.

A medical diagnostic method, system and related equipment particularly adapted to diagnose disorders of the blood circulation serving the head and neck, and especially the brain. A preferred use of the system is early, rapid, accurate, diagnosis of stroke, especially whether the stroke is due to blockage of a blood vessel or leakage from the blood vessel.

The invention discloses a method for processing scalp positioning images of brain tumors, which comprises the following steps of: (1) preliminarily estimating a scalp projected area of a brain tumor of a patient, adhering two mark points which can be identified by an imaging device in the area, obtaining a two-dimensional medical image slice set from the imaging device, and reconstructing a three-dimensional profile of a scalp layer; (2) manually drawing a profile line of the tumor on a two-dimensional image, and reconstructing the surface of the tumor; (3) determining the positions of the two mark points on the two-dimensional image, and reconstructing the mark points; and (4) rotating a profile image of the reconstructed three-dimensional profile image to an appropriate position, and then printing the image in an equal proportion. Compared with the prior art, the method disclosed by the invention is implemented simply; and when the method is applied to the positioning of a brain tumor, the positioning precision meets the demands of tumor resection through a craniotomy, the shortening of operation time and the reduction of surgical traumas are facilitated, and the incision length can be minimized under the premise of guaranteeing good exposures.

The invention relates to a hypertensive encephalopathy monitor, which comprises a monitoring cap and a head fixing belt and also comprises temperature sensing probes, an ambient temperature monitoring probe, an ambient humidity monitoring probe, an ear infrared sensing probe, an epicranium humidity sensing probe, a monitoring main machine, a computer and a power supply, wherein through holes distributed in a multi-point net shape are formed on the monitoring cap along a direction vertical to a spherical surface; the temperature sensing probes are arranged in the through holes respectively; the head parts of the temperature sensing probes are contacted with the epicranium, and the tail parts of the temperature sensing probes extend out of the outside surface of the monitoring cap; the temperature sensing probes are connected with the signal interfaces of the monitoring main machine by wires respectively; and the monitoring main machine is fixed on the monitoring cap and is connected with the computer. The hypertensive encephalopathy monitor is simple in structure and convenient for operation, and can obtain hypertensive encephalopathy information through the abnormal association with the temperature distribution of the skin on the head and realize the real-time monitoring of the diseases in the brain of patients. The hypertensive encephalopathy monitor is designed to avoid influences of various interfering factors to a maximum degree and provide accurate and reliable monitoring results.

The invention discloses a cerebral aneurysm endovascular plastic repair bracket and a conveying device thereof, and solves a technical problem of treating small blood vessels and particularly cerebral aneurysm in a human body. The repair bracket is a netlike cylinder which is wove by elastic alloy wires with diameter of 30-50mum followed by heat treatment to form an elasticated net taking a cylinder shape in a free state, two end portions of the netlike cylinder is sparsely wove and a middle portion is closely wove to form a compact section. In the conveying device, a microcatheter is internally provided with a bracket folded in a straight line shape, a guide wire passes through the bracket, two ends of the bracket is connected with the guide wire by a pushing ring, and the bracket is the netlike cylinder. Compared with the prior art, the bracket composed of short diameter and soft alloy wires benefits isolating cerebral arteries bearing an aneurysm from a cerebral aneurysm neck, reducing thrombosis caused by impact of blood in the arteries bearing the aneurysm on the cerebral aneurysm body and separating the cerebral aneurysm body from the arteries bearing the aneurysm, thus the bracket is applicable to treatment of fusiform cerebral aneurysm.

Disclosed embodiments relate to an apparatus for detecting brain conditions. The apparatus for detecting brain conditions may include: a layer which is located adjacent to the brain of a living body; a light source which is formed on the layer and irradiates light to the brain; and an optical sensor which is formed on the layer adjacent to the light source and detects the light scattered from the brain. Since detection is possible at a location relatively adjacent to the brain, the apparatus for detecting brain conditions may improve accuracy and reliability of detection. The apparatus for detecting brain conditions may be used to detect brain conditions such as cerebral oxygenation, cerebral blood volume, cerebral blood flow, etc. or to monitor brain activities, or to diagnose and / or localize the disease foci in case of neurovascular disease such as stroke including hemorrhage or bleeding, into or around the brain or brain tumors or epilepsy, etc. Since the apparatus for detecting brain conditions has a relatively flexible structure, damage to the brain tissue may be minimized.

The present invention discloses a prosthetic limb hand which is driven and controlled by brain-computer interface and a control method thereof. The prosthetic limb hand comprises the following components: a brain-electrical signal collecting device which is installed in the brain for collecting brain-electrical signal; a signal processing device which executes amplifying and filtering processing to the brain-electrical signal collected by the brain-electrical signal collecting device; a signal extracting recognizing transmitting device which executes characteristic extraction and action mode recognition to the brain-electrical signal obtained by the signal processing device and transmits the information to a prosthetic limb hand driving device; and the prosthetic limb hand driving device which drives the prosthetic limb hand to finish the corresponding action and feed back the action information when the information transmitted by signal extracting recognizing transmitting device is received. The prosthetic limb hand device according to the invention drives the prosthetic limb hand to finish the related action through brain-electric control, successfully prevent the problems of easy muscle fatigue, inferior repeatability, etc. caused by myoelectric control, can execute precise control to the prosthetic limb hand and realizes the hand function more ideally. The invention is suitable for driving control of prosthetic limb hand used by person with disabled upper arm.

Ultrasonic energy has been proven that at suitable frequency range (670-kHz to 2-MHz), ultrasound can be focused to a specific target, and the concentrated energy has sufficient high acoustic pressure so that capable of inducing localized blood-brain barrier (BBB) disruption, which has an important implication on noninvasively delivering drug into brain.

The invention provides a brain disease detection system based on brain pathological age estimation. The brain disease detection system comprises image acquisition equipment, actual age input equipment, a storer, a preprocessing module, a feature extraction module, a feature selection module, a brain pathological age estimation module, a parameter optimization module, a classified recognition module and a result output module; the storer is provided with a VCI sample database, a CTL sample database and a database to be measured. The brain disease detection system has the advantages that the system fully utilizes brain magnetic resonance image characteristics, in combination with the actual age information of samples, simulation training is conducted through a great number of samples, and the obtained brain pathological age estimation module can effectively estimate the brain pathological age of a measured object; meanwhile, deviation between the brain pathological age estimation value and the actual age serves as supplementary information, whether a patient suffers from brain disease or not is effectively diagnosed through infusion with brain image information, the whole system is definite in principle, convenient to implement, more scientific basis is achieved for brain disease detection, reliability is high, and feasibility is high.

Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and / or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and / or compositions in the treatment of subjects having a neurological disease and / or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and / or Chir99021 in the treatment of subjects having a neurological disease and / or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium.

The invention discloses a method for processing multi-mode brain nerve image characteristics, and relates to image preprocessing for extracting image characteristics or features of a recognition figure. The method comprises the following steps of: firstly, performing characteristic selection on multi-mode data by adopting a multi-mode nerve image characteristic selection method with sample weightand low rank constraint to obtain a low-dimensional characteristic matrix, calculating a nuclear matrix of each mode to obtain a low-dimensional characteristic matrix, calculating a nuclear matrix ofeach mode, fusing the nuclear matrices of different modes into a nuclear matrix to select more discriminative biomarker characteristics. New Alzheimer disease sample cases are predicted and classifiedby using a multi-core support vector machine. The defects that, in the prior art, a subject can be injured by using biomarker characteristics, an illness brain area of a patient cannot be found by only using one kind of brain image characteristic data or not fully utilizing the multi-mode brain nerve image characteristics, and the characteristics in the used brain image are free of medical explanation are solved.

A method and neurostimulator for providing therapy to a patient is provided. In one technique, an electrical pulsed waveform is conveyed between a caudal electrode and spinal cord tissue, thereby evoking action potentials that are orthodromically propagated along dorsal column fibers and evoking action potentials that are antidromically propagated along the DC fibers. Electrical energy is conveyed between a rostral electrode and the spinal cord tissue, thereby modulating times that the action potentials orthodromically propagated along the DC fibers arrive at the brain. In another technique, an electrical pulsed waveform is conveyed through a first electrode, thereby evoking action potentials that are propagated along a neural axon, and electrical energy is conveyed through the second electrode. The electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform, such that the action potentials propagated along the neural axon are blocked by the electrical energy.

A fully-automated method for segmentation of white matter, gray matter, and cerebral spinal fluid (CSF) and for calculating their respective volumes is disclosed. The technique preferably uses a T2-weighted scan and a proton-density scan. The T2-weighted scans are used to highlight those portion of the brain corresponding to CSF. Thereafter, the proton density images are separated in CSF-containing and CSF-free portions, in accordance with the T2-weighted images. The CSF-free portion is then segmented into white matter and gray matter portions. The CSF-containing portion is further segmented into pure CSF-regions, and regions containing a mixture of gray and white matter and CSF. After CSF is segmented from this mixture, the white and gray matter and again segmented, and the respective volumes of white matter, gray matter, and CSF are calculated. A technique for determining a threshold gray scale value for segmenting the white and gray matter to assist in the visual identification of such regions is also disclosed.

The invention belongs to the field of pharmaceutic preparations, and relates to a brain targeting drug delivery system which comprises mediated molecules, carriers and drugs, wherein the mediated molecule is fatty acid, the carrier is polycation macromolecule, the fatty acid and the polycation macromolecule are combined to form nano particles or micelles in a covalence mode, and drug loading is completed in an entrapment or absorption mode. The invention utilizes a brain targeting tracing system to perform in-vivo and in-vitro characterization, and the result shows that the drug delivery system in the invention can obviously improve the amount of the drugs entering in the brain by permeating blood brain barriers, delivery gene drugs and diagnostic drugs in the brain by spanning the blood brain barriers and perform prevention and treatment as well as diagnosis on brain diseases. The invention can avoid potential risks and complicated administration process of an invasive administration mode, has small molecular weight and no immunogenicity, and has the advantages of large administration amount, simple administration mode, strong patient compliance and the like compared with a nasal administration mode.

The present invention relates to a novel means to use a fundamental model of the parts of the brain that are dysfunctional in Parkinson's disease, and related dynamical diseases of the brain, as part of a feedback control system to modulate the signs and symptoms of disease. Fundamental computational models that embody our knowledge of the anatomy, neurons, and dynamics of the parts of the brain we wish to control, and use those models to reconstruct what is inaccessible to our measurements. Through emulation the controller synchronizes to the parts of the brain we wish to observe and track. By passing simultaneous control pulses to both the model controller, as well as the brain, we control both the model and the brain. The detailed framework to embed fundamental models of the brain within a control scheme to control symptoms of Parkinsons and related dynamical diseases of the brain are disclosed.

A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention. The method comprises receiving (21) the acquired signals from the sensing electrodes (12), processing (22) the acquired signals to find at least one brain region with atypical neuronal activity, based on the acquired signals determining (23) a spatial distribution of stimulation amplitudes over the array of stimulation electrodes (12), and applying (24) the spatial distribution of stimulation amplitudes to the array of stimulation electrodes (12) in order to stimulate the at least one region with atypical neuronal activity.

The invention provides a double-feedback double-auxiliary hand function rehabilitation training system, which comprises an acquisition device, a multi-modal sliding mode self-adaptive rehabilitation training control center, a staged hand activity training device, at least one of a multi-sensor hand movement intention identification device and a brain neural pathway reconstruction visualization device, and at least one of a functional electrical stimulation (FES) electrode arrangement and stimulation device and a flexible bionic muscle assisting device. The double-feedback double-auxiliary handfunction rehabilitation training system provided by the invention is based on the brain science, the sensing technology, the multi-information fusion technology, the intelligent control, the robot bionic technology and the medical electrical stimulation technology, incorporates the subjective intention that the patient wants to recover into a rehabilitation training strategy, and adopts the internal-external double-feedback double-auxiliary hand rehabilitation training system. The double-feedback double-auxiliary hand function rehabilitation training system demonstrates the brain recovery, nerve reconstruction and muscle recovery of the patient in a visible manner.

The invention discloses a multidimensional vein extracting method based on a brain nuclear magnetic resonance image. An area-of-interests in the brain nuclear magnetic resonance image is segmented through a region growing method. Vein characteristic parameters of the area-of-interests are extracted through a Curvelet conversion and Contourlet conversion method. The people comprise an Alzheimer patient group, a mild cognitive impairment patient group and normal old people group, the vein characteristic parameters of the area-of-interests comprise entropy, gray average, correlation, energy, the homogeneity degree, variance, the maximum probability, deficit distance, an inverse gap, clustering tendency, contrast, a sum mean value, a difference mean value, a sum entropy and a difference entropy. The area-of-interests comprises a entorhinal cortex are and a sea horse area.

Deep Brain Stimulation (DBS) is taking off and will be part of the main treatment for brain diseases such as movement disorders, epilepsy, psychiatric diseases and many others. There is a need for more sophisticated devices that can do more in one penetration, not just stimulate. Once there is a probe in the brain, it is used for multiple passive measurements, without harming the brain further. It provides better understanding the brain and real time closed loop improved treatment. An apparatus and method are disclosed, which allow simultaneous monitoring of multiple parameters inside the human brain, such as: pH, temperature, pressure, seizure activity (EEG), degree of metabolism, oxygen tension in the brain, degree of excitotoxicity and others. The ability to measure those parameters during treatment and stimulation procedures makes the difference between success and failure of the patient.