36 results about "Cell Mobility" patented technology

Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and / or microplates.

Embodiments of the present invention provide a method and a device for reporting cell information and adjusting a cell mobility parameter. The method for reporting cell information includes a connection failure occurring on a terminal and re-establishing a radio resource control RRC connection with a cell by the terminal. A cell identity of a neighboring cell of a source cell and event information of the neighboring cell that is recorded by the terminal before the connection failure occurs is sent by the terminal to a base station that controls a cell where the RRC connection is re-established. Technical solutions provided in embodiments of the present invention may help improve the accuracy of mobility parameter adjustment on a network side and further improve the terminal handover efficiency.

The embodiment of the invention discloses an inter-cell mobility load balance method and the embodiment of the invention also discloses a mobility load balance device. The method includes the following steps: a service base station measuring a user number occupation ratio and a resource occupation ratio of a service cell and when the user number occupation ratio b1 of the service cell exceeds a corresponding threshold t1 or the resource occupation ratio b2 exceeds a corresponding threshold t2, obtaining user number occupation ratios and resource occupation ratios of all adjacent cells of the service cell; and according to user number occupation ratio difference values and resource occupation ratio difference values of the service cell and the adjacent cells of the service cell, selecting a first adjacent cell from all the adjacent cells to carry out load balance processing with the service cell, wherein the load balance processing includes at least one of user number balancing and resource load balancing. Compared with the prior balance methods, the inter-cell mobility load balance method is lower in complexity and capable of better maintaining system balance and stability and ensuring service quality to all users and providing a flexible load balance processing method to operators.

The invention relates to a method for realizing rapid cell selection for a mobile station in a wireless cellular network, comprising: carrying out prediction processing on location cell mobility to obtain a predicted cell priority ranking list, acquiring cell information from a cell information database according to the cell with the highest priority to carry out cell channel measurement and judgewhether the cell residence requirement is satisfied, residing in the cell or continuing taking out the cell which is never subjected to channel measurement from the predicted cell priority ranking list to carry out the above processing operations according to the results. The method is used and the resident historical cell list information is used to carry out mobility prediction by using a corresponding prediction algorithm, thus obviously shortening the wait time of cell selection, substantially improving the user experience, improving the communication service quality to a large extent, optimizing the network resources and workflow and featuring simple, convenient and rapid process, stable and reliable working performance and relatively wide applicable scope.

Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and / or microplates.

The invention discloses a micro-fluidic chip having a three-dimensional graphene interface, and a production method thereof. The micro-fluidic chip realizes the capture of single cells and two cells by designing micro-column capture tanks having different sizes through using hydrodynamics, and an impedance electrical signal during the micro-motion (such as cell adsorption, cell migration and cellproliferation) of single or two cells is quantitatively acquired in real time through a three-dimensional graphene micro-column electrode, so a new idea and a new technique are provided for cancer pathology and single cell detection. The production method of the micro-fluidic chip includes the following steps: producing a patterned gold electrode array, producing a three-dimensional graphene micro-column electrode array, producing a PDMS channel, and producing an openable PDMS cover plate. The micro-fluidic chip processed by the method has good biocompatibility, the production method has the advantages of mild conditions, simplicity, easiness in implementation, and controllable process parameters, and the detected single cell electric signal intensity of the micro-fluidic chip in the invention is twice that of an ordinary micro-fluidic chip.

The invention provides a single cell mass spectrometry method. The method comprises the following steps: carrying out cell immobilization and dilution treatment on cells to be detected so as to obtaina pretreated cell suspension liquid; injecting the pretreated cell suspension liquid into an inner cavity from a tail end of a capillary tube, wherein an electrode is inserted into the inner cavity;applying a voltage to the electrode so that the cells migrate to a capillary tip; completely evaporating the liquid in the capillary tube; dropwise adding an auxiliary liquid to the capillary tip, enabling the auxiliary liquid to enter the capillary tube to be in contact with the cells, extracting a target object; and meanwhile, applying the voltage to the electrode to perform electrospray so thatthe auxiliary liquid containing the target object is ionized, sprayed out from the tip and entering a sample inlet of a mass spectrometer to perform mass spectrometry. According to the method, sampling and mass spectrometry of the single cell can be achieved without depending on a high-precision control platform, identification of a double bond position of unsaturated lipids in the single cell can be achieved in combination with a photochemical derivation process, and an application prospect is good.

This invention provides a method of dynamic cell tracking in a sample comprising the steps of, generating a correspondence measure between cells in two consecutive time-elapsed images of a sample, evaluating said correspondence measure to generate events linking individual cells in the two images, the events being selected from the group: unchanged, cell removal, cell migration, cell collision and cell division, and providing a tracking output of events linking individual cells in the two images. In the invention, the step of establishing linking events involves verifying the correctness of generated cell collision and cell division events, by calculating an adaptive threshold value for each such event and comparing the threshold value with an event parameter. There is further provided a system for dynamic cell tracking in a sample.

The invention discloses a method and a system for transmitting cell mobility state information in LTE (Long Term Evolution), used for solving the technical problem of the change notification mode of the mobility state of a cell in the charge of an adjacency base station in an LTE ad hoc network. In the invention, the adjacency base station of the change can be informed of the mobility state of a cell in the charge of current base station through updating a configuration message by using a base station of an X2 interface, or establishing a request message or a response message by using the X2 interface; a resource base stage also can inform a target base station of the cell mobility state information of a cell in the charge of the resource base station by embedding the cell mobility state information in information of switch preparation failure; and when the cell in the charge of the resource base station is about to modify the physical address of the cell, the target base station can be informed that the cell mobility state of the cell in the charge of the resource base station is in an unavailable state by sending a specific cell physical address modification instruction message. The technical scheme of the invention can ensure successful self-optimization of the current cell, improve network switch success rate and enhance network performance.

The invention provides a composite hydrogel wound dressing and a preparation method thereof. The aminated collagen and oxidized sodium alginate are used as base materials; two polypeptide antibiotics,namely polymyxin B sulfate and bacitracin are loaded; and the AC / OSA-PB composite hydrogel dressing is prepared through a Schiff base reaction. The preparation method is simple to operate; the requirements on reaction conditions are low; gel can be formed in a short time, large-scale production is facilitated, and the prepared wound dressing not only has a good bactericidal effect, but also can improve the HSF cell mobility and the HSF cell proliferation rate to the maximum extent, has excellent wound healing promoting capacity, and also has mechanical properties and mechanical properties suitable for skin wounds.

The invention discloses a trans-pilot-frequency cell mobility scheme realizing no downstream data loss of group calling terminal. The scheme includes that an access network configures a measurement threshold established for triggering RRC connection for the group calling terminal and the terminal triggers an RRC connection establishing process after meeting the measurement threshold; after the group calling terminal implements the establishing of the RRC connection, the access network configures a pilot frequency measurement GAP according to a group mark of a group calling UE and the group calling terminal uses the pilot frequency measurement GAP for pilot frequency measurement; the access network triggers the ground calling terminal to switch to a target pilot frequency cell if pilot frequency switching conditions are met. According to the invention, through the arrangement of the measurement threshold and the triggering of the establishment of the RRC connection after that the terminal meets the measurement threshold is judged, pilot frequency measurement of the group calling terminal is realized. Thus, the group calling terminal is triggered to switch to the target pilot frequency cell after the access network meets the pilot frequency switching conditions. Therefore, pilot frequency GAP measurement and switching in group calls area realized and downstream data loss of the terminal is avoided and data transmission reliability is kept.

The invention discloses an adjustable cell-culture dish scratch device which is composed of a worktable mechanism, an operating mechanism and a control mechanism, wherein the operating mechanism and the control mechanism are respectively arranged on the worktable mechanism; during use, a culture dish is arranged on a worktable plate, the operating mechanism can move up and down on a lifting rod, the cell scratch depth can be observed through a display screen, and by meshing a gear and a gear groove, back-and-forth movement of a scraper device can be adjusted, and the cell scratch length can beobserved through the display screen. The adjustable cell-culture dish scratch device disclosed by the invention is scientific and reasonable in structure and convenient to operate, scratch with fixedwidth and depth can be accurately performed, the scratch depth can be adjusted, the flooring material on the lower part of cells is not influenced, the scratch positioning is accurate, the scratch width can be scratched according to different scratching tools, and the cell migration ability level can be observed. The adjustable cell-culture dish scratch device comprises a camera assisted system and can perform fine width and depth adjustment, and the cell scratch quality is improved.

System (PAA-BSS) comprising a plurality of access points (AP), defining a pre authentication area (PAA), the system communicating a list of frequencies relating to the access points of the pre-authentication area (PAA) and information as to the relative position of the access points to the a mobile station seeking pre-authentication before the system. Method of preparing a mobile station for handover between access points, wherein the mobile station associating (11, 21, 31) with a first access point in a predetermined group of access points (PAA-BSS) defining a pre-authentication area (PAA), the mobile station authenticating (12, 22, 32) itself before at least one prevalent access point of the group (PAA-BSS), upon being accepted for authentication before the prevalent, the mobile station receiving a response comprising a list of frequencies (14, 24, 34) pertaining to access points of the group (PAA-BSS).

A procedure is disclosed where a user equipment (UE) 10 can share information (with e.g. radio access network (RAN) nodes 20, 30) about its cell mobility attempts (e.g. redirection successes / failures). This information can subsequently be utilized by the various RAN nodes 20, 30 when making subsequent, i.e. future, cell mobility decisions. Hereby it is made possible to improve cell mobility decisions, such as redirection or handover, by the various RAN nodes 20, 30.

The invention relates to new application of alantolactone, in particular to application of the alantolactone serving as an anti-angiogenesis drug. The application has the advantages that the activity of an HUVEC (Human Umbilical Vein Endothelial Cell) is detected through a CCK-8 method, and a cell mobility inhibition experiment, a cell migration inhibition experiment, a tube formation inhibition experiment, an in-vivo anti-angiogenesis activity experiment and the like show that the alantolactone can effectively resist angiogenesis. The application shows that the alantolactone has an inhibition effect on an MDA-MB-231 breast tumor and has a prospect of treating a breast cancer. A first research on a VEGFR2 and downstream signal passageway shows that the alantolactone can obviously inhibit phosphorylation of the VEGFR2 and also obviously inhibit phosphorylation of VEGFR2 downstream signal molecules including PLC(gamma)1, FAK, Src and AKT.

The invention discloses toning lotion containing sweet pea extract solution and a preparation method thereof. The toning lotion containing the sweet pea extract solution disclosed by the invention is characterized by comprising the following components in percentage by weight: 6.5-7.5% of 1,3-butanediol, 1.0-2.0% of 1,2-pentanediol, 1.0-2.0% of glycerinum, 0.1-1.0% of betaine, 0.5-1.5% of glucose, 0.1-0.5% of sweet pea extract solution, 0.1-0.8% of rosemary extract, 1.0-3.0% of algal polysaccharides, proper essence, and the balance of purified water. The toning lotion containing the sweet pea extract solution disclosed by the invention has the functions of preserving moisture, moisturizing, promoting cell regeneration and waking up skin vigor and is capable of effectively promoting cell mobility and proliferation and preventing and improving skin aging, so that skin is moist, tightened, high-elastic and smooth; the toning lotion containing the sweet pea extract solution is extracted from natural plants; components are safe and effective.

A cell mobility characteristics sensing apparatus including a laser light source, a light sensor, an analyzing chip, and a display is disclosed. The laser light source emits laser beams to a cell sample. The light sensor senses scattered laser beams formed by the cell sample scattering the laser beams at a plurality of time points to obtain a plurality of laser scattering patterns corresponding to the plurality of time points respectively. The analyzing chip obtains a laser scattering pattern fluctuations information of the plurality of laser scattering patterns varied with the plurality of time points to estimate the mobility characteristics of the cells in the cell sample. The display shows the mobility characteristics of the cells in the cell sample estimated by the analyzing chip.

The invention discloses an active artificial blood vessel capable of achieving repeated puncture and a preparation method thereof, belongs to the field of tissue engineering, and particularly relatesto an autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture, a preparation method thereof and a vascular skeleton for preparing the autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture. The preparation method of the autologous endothelialization engineering blood vessel capable of achieving repeated puncture comprises the following steps: implanting the vascular skeleton into an animal or a human body, enabling the vascular skeleton and a blood vessel of the animal or the human body to be connected in parallel and sewn, and taking out the sewn vascular skeleton after 7-62 days to obtain the autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture. The artificial blood vessel has the beneficial effects that: intimal hyperplasia and thrombus can be effectively inhibited; autologous blood vessels at any position can be replaced, and endothelializationblood vessels of corresponding sizes can be customized according to needs; and the preparation technology is high in controllability, the mechanical property and the cell mobility of a vascular skeleton are controlled by controlling a skeleton structure (wall thickness, fiber diameter, pore diameter, layer number and textile angle), and the gold standard of the artificial blood vessel is achieved.

An indication signal is used for indicating to a UE a communication resource for a second reference signal that is part of a higher-layer configuration from a first base station. The communication resource for the second reference signal is associated with a second base station. The higher-layer configuration also includes a communication resource for a first reference signal associated with the first base station. A UE that receives an indication signal communicates with the second base station. A data transmission or a control signal transmission could be communicated with the second base station using a respective data channel or control channel. The data channel or control channel is associated with the communication resource for the second reference signal.

The invention relates to a chip device for cell migration experiment, a preparation method thereof and an experiment method, the technical problems that the process of using a cell arrangement deviceis tedious, the cell pollution probability is high, and the experiment precision is influenced can be solved. Wherein the surface of the chip comprises a plurality of repetitive function units; wherein each functional unit at least comprises three functional areas of an inoculation area, an isolation area and a migration area; the inoculation area is an area where cells are initially inoculated and adhered, and the surface of the inoculation area has hydrophobicity; the isolation area is an isolation column array arranged on the periphery of the inoculation area, the isolation column array surrounds the inoculation area to form an annular structure, a set gap is reserved between every two adjacent isolation columns, and the outer surfaces of the isolation columns have hydrophobicity; and the migration area is at periphery of the isolation area. The cell initial inoculation range is limited, cells can be controlled to migrate to the designated area range and direction, meanwhile, structures of different migration interfaces in vivo can be simulated, damage operation does not need to be conducted on the cells, and a chip does not need to be disassembled and assembled.

The present invention provides a method and system for analyzing a network of biological functions, such as transcriptional factors, structural genes, cellular markers, cell surface markers, cell shapes, organelle shapes, cell mobility, enzyme activities, metabolite concentrations, and localization of cellular components, in a biological entity such as a cell. Particularly, an object of the present invention is to provide a system and method for presenting biological information in a global manner without modification where the cell is considered a complex system.

A three-dimensional cell sphere migration monitoring method based on microfluidic chip technology is provided, especially for the process of three-dimensional cell sphere migration into a three-dimensional matrix. The microfluidic chip is mainly composed of a cell inlet pool, a collagen inlet pool, a culture medium inlet pool, a waste liquid pool, a cell culture chamber, a medium perfusion chamber, a cell ball capture chamber, and a cell migration chamber. The method mainly includes the following steps: (1) chip collagen perfusion; (2) chip cell ball inoculation and culture; (3) chip cell migration real-time monitoring. The three-dimensional cell spheroid migration dynamics monitoring method based on the microfluidic chip has the characteristics of real-time tracking of cell movement, and at the same time can realize accurate positioning of the beginning of cell movement.

The invention discloses a micro-fluidic chip having a three-dimensional graphene interface, and a production method thereof. The micro-fluidic chip realizes the capture of single cells and two cells by designing micro-column capture tanks having different sizes through using hydrodynamics, and an impedance electrical signal during the micro-motion (such as cell adsorption, cell migration and cellproliferation) of single or two cells is quantitatively acquired in real time through a three-dimensional graphene micro-column electrode, so a new idea and a new technique are provided for cancer pathology and single cell detection. The production method of the micro-fluidic chip includes the following steps: producing a patterned gold electrode array, producing a three-dimensional graphene micro-column electrode array, producing a PDMS channel, and producing an openable PDMS cover plate. The micro-fluidic chip processed by the method has good biocompatibility, the production method has the advantages of mild conditions, simplicity, easiness in implementation, and controllable process parameters, and the detected single cell electric signal intensity of the micro-fluidic chip in the invention is twice that of an ordinary micro-fluidic chip.

The invention provides an assembling device for a cell migration micro-fluidic chip and belongs to the technical field of microfluidics. The assembling device is capable of solving the technical problems of the present micro-fluidic chip that routes are easily blocked and microcolumns are easy to deform during a mounting process, and the like. The assembling device for the cell migration micro-fluidic chip comprises a frame; dedusting drums are fixed on the frame; dust-free boxes are fixedly connected with the dedusting drums; a dedusting structure is arranged in each dedusting drum; a wire, which is clung to and spirally wound on an inner wall, is fixedly arranged in each dedusting drum. A strong electric field can be generated after the wire is powered on; one end of a first dedusting drum is closed by a first closing plate; one end of a second dedusting drum is closed by a second closing plate; a plurality of feeding ports for feeding are formed on the first closing plate; a plurality of discharging ports for discharging are formed on the second closing plate; dedusting components for promoting the dedusting effect are arranged in the dedusting drums. The assembling device for the cell migration micro-fluidic chip has the advantages that the routes are unlikely to be blocked and microcolumns are unlikely to deform during a mounting process.