Composite hydrogel wound dressing and preparation method thereof

Abstract

The invention provides a composite hydrogel wound dressing and a preparation method thereof. The aminated collagen and oxidized sodium alginate are used as base materials; two polypeptide antibiotics,namely polymyxin B sulfate and bacitracin are loaded; and the AC / OSA-PB composite hydrogel dressing is prepared through a Schiff base reaction. The preparation method is simple to operate; the requirements on reaction conditions are low; gel can be formed in a short time, large-scale production is facilitated, and the prepared wound dressing not only has a good bactericidal effect, but also can improve the HSF cell mobility and the HSF cell proliferation rate to the maximum extent, has excellent wound healing promoting capacity, and also has mechanical properties and mechanical properties suitable for skin wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a composite hydrogel wound dressing and a preparation method thereof. Background technique [0002] Skin wound repair is one of the major challenges facing the medical field. According to the statistics of the World Health Organization, about millions of people in the world suffer from skin injuries every year, and about 180,000 people die from burns rather than fatal burns. is the main causative factor. Large-scale non-fatal wounds destroy the normal physiological functions of the skin. Without timely and effective treatment, the wound is very likely to be invaded and infected by microorganisms, thereby delaying wound healing, and in severe cases, life-threatening. Therefore, effective control of wound infection and rapid promotion of wound healing are important ways to reduce patient death. Full-thickness skin wound tissue undergoes a complex process ...

AI Technical Summary

Problems solved by technology

The prepared fish skin collagen-chitosan composite alginate hydrogel dressing can effectively shorten the healing period, eliminate wound inflammation, and inhibit scar formation, and has a good prospect and application direction in wound care. There are many defects, as follows: (1) Sodium alginate, fish skin collagen, polyvinyl alcohol and glycerin are used to prepare the gel solution, polyvinyl alcohol is an organic compound, which is harmful to the human body; Place it under the condition of ℃ for 2 hours, and then add the cross-linking agent prepared by chitosan and anhydrous calcium chloride to carry out the cross-linking reaction. The whole cross-linking process usually takes several hours to realize gelation. production efficiency, and the cross-linking steps are cumbersome, which increases uncertainties; (3) Compared with other hydrogels, Ca 2+ The hydrogel prepared by cross-linking has the characteristics of unevenness, hardness and brittleness, which is not conducive to the comfort of the wound

In addition, the incorporation of calcium ion impurities has a certain impact on wound healing; (4) chitosan, as a natural antibacterial agent, has poor antibacterial effect compared with antibiotics, and the antibacterial concentration and antibacterial concentration of chitosan The performance is closely related to its preparation process, molecular weight and molecular structure. At present, chitosan is mainly obtained through extraction methods, which requires high control of raw materials and production processes, making it difficult to grasp the production stability of chitosan, which also leads to The antibacterial effects of chitosan products on the market are uneven, which increases the trouble of screening chitosan

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