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34 results about "Anti aggregation" patented technology
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Polyconjugates for In Vivo Delivery of Polynucleotides
ActiveUS20080152661A1Reduce aggregationEnhances transfection activityPowder deliveryPeptide/protein ingredientsDelivery vehicleNucleotide
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Polyconjugates for In Vivo Delivery of Polynucleotides
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Compounds and methods for reversible modification of biologically active molecules
Owner:ARROWHEAD MADISON
Polyconjugates for in vivo delivery of polynucleotides
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Cervical exfoliated cell preservative fluid
InactiveCN101363011AReduce aggregationEfficient killingDead animal preservationTissue cultureRed blood cellCervical cancer screening
The invention relates to a cervical exfoliated cell preservative liquid, the preservative liquid comprises the following components with the contents (by weight): 20 percent to 50 percent of alcohols; 15 percent to 50 percent of anti-aggregation reagent; 5 percent to 10 percent of buffer solution; 1 percent to 20 percent of ion strength maintaining reagent; 0.01 percent to 0.5 percent of anti-microbial reagent; 0.1 to 5 percent of mucus dissolving reagent; and 0 to 0.5 percent of cleaning agent. Compared with the prior art, the preservative liquid can not only lead cells to maintain the shape in an in vitro liquid suspension environment, minimize the protein precipitation, dissolve larger protein substances, such as blood and mucus, and reduce the cell aggregation, but can also selectively eliminate or reduce red cells, effectively kill microbes, prevent the activity of reverse transcriptase and retain the integrity of nucleic acids and proteins for facilitating the later analysis; in addition, the preservative liquid can greatly reduce the costs of consumptive materials for the TCT detection, improve the sensitivity and the specificity of the cervical cancer screening and accelerate the promotion and the popularization of the TCT technology in a medical system.
Owner:SHANGHAI ADICON CLINICAL LAB LNC
Endosomolytic Poly(Acrylate) Polymers
ActiveUS20080287630A1Reduce aggregationEfficient transfectionOther foreign material introduction processesPharmaceutical non-active ingredientsActive polymerIn vivo
The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Endosomolytic Poly-Beta-Aminoester Polymers
Owner:ROCHE MADISON
Endosomolytic Poly(Vinyl Ether) Polymers
InactiveUS20080287628A1Microencapsulation basedPharmaceutical non-active ingredientsVinyl etherActive polymer
The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Compounds and Methods for Reversible Modification of Biologically Active Molecules
InactiveUS20080281074A1Reduce aggregationEfficient transfectionPeptide/protein ingredientsGenetic material ingredientsIn vivoTransfection
The present invention is directed compounds for reversibly modification of biologically active molecules. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Composite hydrate inhibitor and application thereof
ActiveCN102181275ANon-volatileGood chemical stabilityPipeline systemsDrilling compositionSuper cooling2-Vinylpyridine
The invention discloses a composite hydrate inhibitor and application thereof. The provided composite hydrate inhibitor comprises a copolymer and an anti-aggregation agent; the copolymer is selected from at least one of the following substances: poly (N-vinyl pyrrolidone-2-vinyl pyridine) and poly (N-vinyl caprolactam-2-vinyl pyridine); and the anti-aggregation agent is a quaternary ammonium saltcompound. When the series of copolymer and the anti-aggregation agent are interacted, the composite hydrate inhibitor has good hydrate generation inhibiting performance. The hydrate inhibitor is in aliquid state, and can be used in the range that the water content is 10 to 80 weight percent, the pressure is 1.5 to 70MPa and the temperature is 20 DEG C below zero to 25 DEG C. The hydrate inhibitor cannot be limited by super-cooling degree, and is suitable for oil and water coexistence or oil-gas field and crude oil recovery; and particularly under the condition of high water content, the hydrate nucleation and aggregation inhibiting effects of the inhibitor can be fully exerted. The inhibitor has the advantages of high efficiency, economical efficiency, low dose and good biodegradability,and has good application prospect.
Owner:CHINA NAT OFFSHORE OIL CORP +1
Anti-microbial-adhesion fraction derived from vaccinium
A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
Owner:RAMOT AT TEL AVIV UNIV LTD
White and interference-color matte flaky cored pigment and preparation method thereof
ActiveCN105542517ASmall particle sizeGood skin affinityInorganic pigment treatmentInterference colorFiltration
The invention discloses a white and interference-color matte flaky core-covered pigment and a preparation method thereof and relates to the field of pearlescent pigments. A base material with the grain diameter D50<=5 micrometers is coated with white metallic oxide to form a coating layer. According to the method, the base material and water are mixed to form suspension liquid, a crystal grain modifier is put in the suspension liquid, a metallic oxide crystal type transforming agent is added into the suspension liquid, the pH value is regulated, a saline solution is added dropwise into the suspension liquid, the pH value of the suspension liquid is kept stable at the same time, stirring is continued after adding is over, the pH value of the solution is regulated, an anti-aggregation agent is added, and suction filtration, drying, calcining and cooling are performed on the solution after adding is over. Compared with the prior art, the pigment prepared through the method is small in grain diameter, very fine and smooth, quite obvious in skin effect, high in covering force, good in ultraviolet absorption effect, low in luster, remarkable in matte effect and capable of being widely applied to cosmetics, sun cream, pigment toning and other industries.
Owner:GUANGXI CHESIR PEARL MATERIAL CO LTD
Methanol gasoline multipurpose additive and application thereof
InactiveCN102911752AReduce pollutionImprove protectionLiquid carbonaceous fuelsIsobutanolCerium nitrate
The invention discloses a methanol gasoline multipurpose additive and application thereof. The methanol gasoline multipurpose additive comprises the components of isobutanol, isoamylol, acetone, dimethylbenzene, tertiary butanol, methyl tertiary butyl ether, cerium nitrate, 2, 4- dimethyl-6- tert-butyl phenol, 102 TB corrosion inhibitor and dcyclopentadiene iron. According to the invention, raw materials can be obtained easily, the processing is simple, the price is low, and the methanol gasoline multipurpose additive has good anti-detonating quality, vaporability and stability; the pollution is low after the combustion, so that the environmental protection is facilitated; the antioxidant component in the methanol gasoline multipurpose additive can prolong oxidation and dispersion time for sediment particles, so as to have an anti-aggregation raw rubber stabilizing effect on oil product olefins; the methanol gasoline multipurpose additive can prevent a filter and a nozzle from being polluted and blocked; and all components work together to improve the safety of methanol gasoline.
Owner:许 建忠
Method for preparing anti-aggregation modified nano calcium carbonate
InactiveCN110591415AGood anti-agglomeration effectImprove performanceCalcium/strontium/barium carbonatesInorganic pigment treatmentCALCIUM HYDROXIDE SOLUTIONCarbonization
The invention discloses a method for preparing anti-aggregation modified nano calcium carbonate. The method comprises the following steps: (1) treating a calcium hydroxide solution; (2) performing carbonization treatment; (3) performing modification and suspension treatment; and (4) preparing anti-aggregation nano calcium carbonate. By adopting the method for preparing anti-aggregation modified nano calcium carbonate, due to reasonable process designing, the prepared nano calcium carbonate has excellent anti-aggregation performance, and the modified nano calcium carbonate is high in activity,good in size stability, excellent in performance and wide in market prospect.
Owner:CHANGSHU HONGYU CALCIFICATION CO LTD
Endosomolytic poly(vinyl ether) polymers
Owner:ARROWHEAD MADISON
Membrane active heteropolymers
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
Owner:ARROWHEAD MADISON
Anti-thrombocyte tetratitanate-NB06 and its application
InactiveCN101045746AHigh activityImprove stabilityTetrapeptide ingredientsBlood disorderGlycineAnti platelet
This invention relates to a new thrombocyte anti-aggregation tetrapeptide - NB06, its amino acid sequence is omega - aminocaprylic acid - glycine - aspartic acid - tryptophyl amine peptide. The amidated carboxyl terminal could enlarge top space of 'V' type peptide, thereby enhance biology activity of object compound, along with it advance its ability of resisting hydrolization, establish good foundation for its using in preparing drugs for thrombocyte anti-aggregation and cerebrovascular disease treatment.
Owner:牛勃
Endosomolytic poly(acrylate) polymers
InactiveUS8017109B2Other foreign material introduction processesPharmaceutical non-active ingredientsActive polymerIn vivo
Owner:ARROWHEAD MADISON
Compound hydrate anti-aggregation agent composition and uses thereof
ActiveCN107312513AIncrease dosageOvercoming a large amountDispersed particle separationPipeline systemsOil waterPollution
The present invention relates to a compound hydrate anti-aggregation agent composition and uses thereof. A purpose of the present invention is mainly to solve the problem of easy environment pollution, poor aggregation resistance and high consumption in the prior art. The technical scheme of the present invention comprises a compound hydrate anti-aggregation agent composition and uses thereof, wherein an oil-water emulsifier, a hydrate particle anti-aggregation agent, a hydrate particle dispersant and a synergist are compounded according to a mass ratio of 0.1-5:0.1-10:0.1-10:0.1-10 to obtain the compound hydrate anti-aggregation agent composition. With the technical scheme of the present invention, the problem in the prior art is well solved. The compound hydrate anti-aggregation agent composition of the present invention can be used for oil and gas transportation.
Owner:CHINA PETROLEUM & CHEM CORP +1
Surfactant composition
Owner:ENZA BIOTECH
Composite hydrate inhibitor and application thereof
ActiveCN102181275BPromote degradationNon-volatilePipeline systemsDrilling compositionSuper cooling2-Vinylpyridine
Owner:CHINA NAT OFFSHORE OIL CORP +1
Half mirror, light guide device, and display device
InactiveUS20180348521A1Small thicknessReduce reflectivityMechanical apparatusPlanar/plate-like light guidesLight guideDisplay device
A half mirror includes a silver layer and an anti-aggregation layer in contact with the silver layer. The anti-aggregation layer may be composed of ITO or IGO. Alternatively, the anti-aggregation layer may be composed of an organic molecular film having a thiol group. Alternatively, the anti-aggregation layer may be composed of an alloy including silver in an amount of 97% or more and an element X, in which the element X is any one of Au, Mg, Zn, Cu, Al, Si, Pd, Sn, Pt, Ti, and Cr.
Owner:SEIKO EPSON CORP
Cell dispersion treating agent
The invention provides a finishing agent for the cell dispersion which makes the cells of different size and tissue mass with many cells carry the same charges by the interface chemical technology. So it has the anti-aggregation effect in the limit liquid. Concretely speaking, the cell suspension for smearing is added into the proper finishing agent such as the butyl naphthalene sulfonic acid sodium 0.1-10% to make the cell thin and uniform in the slide. Also, it is benefit for the storage of the cell.
Owner:徐朝斌
A sterilizing bacteriostatic laundry detergent and a preparing process thereof
ActiveCN109554250AExcellent anti-associative effectGood antibacterial effectSurface-active detergent compositionsSurface-active non-soap compounds and soap mixture detergentsPotassium hydroxideSodium sulfate
A sterilizing bacteriostatic laundry detergent and a preparing process thereof are disclosed. The laundry detergent includes, by weight, 0.8-8 parts of parachlorometaxylenol, 1.21-24.28 parts of an anti-aggregation component, 1-10 parts of an aqueous solution of ethanol, 2-20 parts of a strong surfactant, 0.05-1 part of tea tree essential oil, 1-10 parts of PEG-40 hydrogenated castor oil, 0.05-0.2part of a calcium-magnesium chelating agent, 0.1-1.5 parts of sodium chloride, and 42.35-83.36 parts of deionized water. The anti-aggregation component consists of refined castor oil and potassium hydroxide. The strong surfactant includes at least two of polyoxyethylene alkyl ether sodium sulfate, polyoxyethylene alkyl ether, and polyglyceryl fatty acid ester. The laundry detergent has good dirt-removing power and sterilizing and bacteriostatic capabilities.
Owner:JOTM DAILY CHEM HANGZHOU CO LTD
Anti-aggregation humanized IgG (immunoglobulin G) antibody CH2 structural domain mutant and application
ActiveCN108191974AReduce production processReduce storage costsAntibody mimetics/scaffoldsImmunoglobulins against animals/humansCell AggregationsMonoclonal antibody
The invention discloses an anti-aggregation humanized IgG (immunoglobulin G) antibody CH2 structural domain mutant and an application. A CH2 fragment of an IgG antibody serves as an object; an easy aggregation area is predicted on a basis of the existing transformation framework m01s; and further optimization is performed to form a new framework m01sm1. M01sm1 has higher stability than the mutantm01s; the development of a more stable C single domain antibody is facilitated; production, purification and storage cost of a monoclonal antibody or Fc fusion protein can be lowered; the anti-aggregation ability of m01sm1 is better; and clinical use risks caused by protein aggregation can be reduced.
Owner:武汉班科生物技术有限公司
Compositions and methods for repelling coleopterans
ActiveUS20170280731A1Improve accessibilityImplement control measureBiocideAnimal repellantsMethacrylatePaleontology
Owner:ISCA TECH
Method for dendroctonus armandi disorientation control by pheromones
InactiveCN110419515AAvoid gatheringSolve the difficult problems of field control during the raising periodBiocidePest attractantsPaleontologyDendroctonus armandi
The invention discloses a method for dendroctonus armandi disorientation control by pheromones. The method includes the steps: dividing an armandi distribution area into an affected area, an unaffected area and an armandi-free distribution area in an emergence period of dendroctonus armandi; preparing host plant volatiles and dendroctonus armandi aggregation pheromones into attractants; suspendinga slow-release bottle with the attractants in the armandi-free distribution area; preparing anti-aggregation substances by taking anti-aggregation pheromones and organic matter liquid without attracting and avoiding functions for the dendroctonus armandi as solvents. By combined use of the aggregation pheromones and the anti-aggregation pheromones, the efficiency of the dendroctonus armandi harming healthy armandi is effectively reduced, and the problem of difficulty in field control of the dendroctonus armandi in the emergence period is solved. By comprehensively using three identified aggregation pheromone substances of the dendroctonus armandi, the efficiency of trapping and attracting the dendroctonus armandi is improved, and the dendroctonus armandi is disorientated.
Owner:SOUTH CHINA AGRI UNIV
Surfactant composition
A surfactant composition comprises at least one alkylglycoside having the formula CnGm wherein C is an alkyl group that is unbranched or branched, saturated or unsaturated, derivatised or non-derivatised, and n is the number of carbon atoms in the alkyl group and is 14 to 24. G is a saccharide residue containing 5 to 6 carbon atoms, and m is a number from 4 to 20. The use and application of the surfactant composition in detergents, emulsifying agents, wetting agents, anti-aggregation and stabilising composition and dispersants comprising the same is also disclosed.
Owner:ENZA BIOTECH
TNFr and stability and anti-aggregation performance enhanced Fc fragment fusion protein as well as preparation method and application thereof
InactiveCN107936124AReduce production processCheap purificationPeptide/protein ingredientsAntibody mimetics/scaffoldsCell AggregationsWild type
The invention discloses TNFr and stability and anti-aggregation performance enhanced Fc fragment fusion protein as well as a preparation method and application thereof. A pair of disulfide bonds are respectively introduced into CH2 and CH3 structure domains of the Fc fragments of the TNFr-Fc fusion protein; the mutation type TNFr-S23 fusion protein is obtained. Compared with wild type TNFr-Fc, theprotein has the advantages that the stability is higher; the production, purification and storage cost of the protein can be reduced. Compared with wild type TNFr-Fc, the protein has the advantages that the anti-aggregation performance is better; the clinic use risk caused by protein aggregation can be reduced.
Owner:武汉班科生物技术有限公司
Acellular pertussis vaccine detoxified with hydrogen peroxide and preparation method thereof
InactiveCN105106947AStrong oxidation abilityNo side effectsAntibacterial agentsBacterial antigen ingredientsProtective antigenImmunogenicity
The invention relates to an acellular pertussis vaccine, which contains a PT antigen and an FHA antigen in the supernatant part of a bordetella pertussis liquid culture and a PRN antigen in the thallus part of the bordetella pertussis liquid culture. Specifically, the PT antigen and the FHA antigen adopt hydrogen peroxide as the detoxifier, take glycerin as the anti-aggregation agent, and employ urea as the protective agent to conduct detoxification. The detoxified pertussis stock solution has good immunogenicity, is free of residual substances harmful to the human body, and has good immunogenicity and a broader spectrum of antigenicity. The invention also relates to a preparation method of the acellular pertussis vaccine, and a preparation method of a combined vaccine containing the acellular pertussis vaccine.
Owner:HUALAN BIOLOGICAL ENG INC +1
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