The invention provides actinidia kolomikta wine with functions of strengthening brains and calming the nerves and a production method thereof. The wine takes actinidia kolomikta, cornu cervi degelatinatum, asiatic cornelian cherry fruit, sagittaria sagittifolia, ginseng, rhizoma polygonati, gymnadenia conpsea, fragrant solomonseal rhizome, semen cassiae, cicada slough, mulberries, lily, agrimony, barbary wolfberry fruit, silktree albizia bark, sesame and tabasheer as main raw materials. The production method comprises the main process flows of material selection, drying, mixing, soaking, packaging and finished product preparation. The wine has the advantages of health care, heart nourishing and nerves calming, refreshing the benefiting brains, quick effect, pure natural property, no toxic or side effect and the like, has good auxiliary treatment effects on main diseases such as dizziness, blurry eyes and the like and is suitable for drinking at home.