The present invention relates to compound feed for adult fish of mystus nemurus, belonging to the technical field of aquaculture. The compound feed comprises the following ingredients by weight: 10-18% of domestic fish meal, 16-21% of soybean meal, 11-15% of cottonseed meal, 6-10% of rapeseed meal, 6-8% of corn gluten meal, 6-8% of rice bran, 13.23-20.23% of wheat middling, 4-6% of Saccharomyces cerevisiae, 2.1-2.5% of fish oil, 5.2-5.6% of soybean oil, 0.5-1.0% of soy lecithin, 0.8-1.5% of calcium dihydrogen phosphate, 0.05-0.1% of L-ascorbate-2-monophosphate, 0.2-0.3% of choline chloride, 0.2-0.4% of salt, 0.01-0.03% of ethoxyquin, 0.5-1.0% of mineral premix, and 0.3-0.8% of vitamin premix. According to the present invention, the compound feed is reasonable in ingredient ratio, balanced in nutrition, low in feed coefficient and cost and easy to spread; and the feed has good palatability, a high feed conversion ratio, little pollution to water bodies, stable sources of raw materials, and low cost, suitable for large-scale adult fish farming of mystus nemurus.