The invention relates to the field of compound fertilizer for crops, in particular to a slow-release compound fertilizer for disease-resistant and strong seedlings specially used for sugarcane planting. The compound fertilizer is prepared from the following raw materials in parts by weight: urea 30-32, ammonium nitrate 10-12, biogas residue 6 -8, rapeseed cake fertilizer 15-18, bamboo tube 6-8, rice straw 8-10, river sand 15-18, potassium dihydrogen phosphate 28-30, walnut shell 3-5, glucose 5-8, calcium lactate 0.2 -0.3, borax 4-5, copper citrate 0.2-0.3, ferrous citrate 2-4, sodium methyl silicate 0.01-0.02, sodium dodecylbenzenesulfonate 0.2-0.3, sodium dehydroacetate 6- 8. Baking powder 12-15, malt root 4-6, mannoprotein 2-5, β-aminoisobutyric acid 0.01-0.02, polyvinyl alcohol 8-10, loach powder 1-3, additives 3-5; The compound fertilizer of the present invention is made of bamboo tubes, rice grass clippings and other raw materials into absorbent powder, which is mixed with raw materials such as organic fermentation liquid and auxiliary agents to achieve the effect of solid fertilizer, and the effect of slow and controlled release fertilizer is realized by using the coating agent. The compound fertilizer of the invention has long-lasting fertilizer effects, strong seedlings and lush leaves, strong disease resistance, and obvious effects of increasing production and income.