The invention relates to animal disease prevention and control equipment, in particular to an animal tissue sampler, which comprises a first arm handle, a secondary arm handle, an upper jaw and a lower jaw, wherein the first arm handle and the lower jaw are integrated into one body, the secondary arm handle and the upper jaw are integrated into one body, the first arm handle and the secondary arm handle are connected by a rotary shaft, a cutter is fixedly arranged on the lower part of the lower jaw, a through hole corresponding to the cutter in term of position is arranged on the lower jaw, a baffle and a pipe clamp are fixed on the lower part of the lower jaw, the right end of the baffle is fixedly connected with a pushing device, at least one sampling pipe is arranged between the pushing device and the right end of the pipe clamp, the upper part of the pipe clamp is fixed with two side surfaces of the lower jaw, a clamping groove is formed in the middle of the right side of the pipe clamp, the sampling pipes are arranged in the clamping groove, and the sampling pipe on the right end of the pipe clamp is corresponding to the through hole in term of position. The animal tissue sampler can simply, quickly, conveniently and easily sample, with less stress on animals, and the tissue samples are normative and unified, and easy to collect without pollution.