The invention relates to the field of woolen blanket preparation, and discloses a method for preparing a spherical pillowcase woolen blanket with a healthcare and skin friendliness character. The method comprises the steps of 1, gray fabric preparation, wherein anion far-infrared functional dacron lustrous fibers are adopted as surface yarn, dacron fully-drawn yarn is adopted as bottom yarn, and beaming, warp knitting and slitting are carried out in sequence; 2, gray fabric pre-finishing, wherein shaping, inverse pre-ironing, smooth high combing, inverse lustring, smooth fine brushing, inverselustring and smooth lustring are carried out; 3, printing and dyeing, wherein random dyeing, drying, ageing, washing and dewatering are carried out; 4, after finishing, wherein wet cloth dry shaping,pre-ironing, wool brushing, front face lustring, lustring and iron shearing are carried out; 5, finished product treatment, wherein tailoring, rough selvedge sewing and spherical ornamental sewing are carried out. According to the method, the anion far-infrared functional dacron lustrous fibers are adopted as raw materials, gray fabric is subjected to pretreatment, printing, washing, drying and finishing, finished product edge sewing and flat turning procedures are carried out, ornamentals and a woolen blanket are combined, and the spherical pillowcase woolen blanket is developed. The prepared woolen blanket has the a healthcare and skin friendliness character, is high in grade and appearance level and accords with popularization.