The invention discloses a hangover-alleviating tablet and a preparation method thereof, which belongs to the field of hangover-alleviating tablets. The hangover-alleviating tablet is prepared from the following components in parts by weight: 20 to 30 parts of corn oligopeptide, 18 to 25 parts of radix puerariae, 8 to 12 parts of rhizoma curcumae longae, 10 to 15 parts of fermented soybean powder, 8 to 10 parts of black pepper powder, 6 to 8 parts of ground black pepper, 6 to 8 parts of sorbitol, 4 to 6 parts of xylitol, 4 to 6 parts of sucralose, 0.1 to 0.3 part of edible essence, 1 to 3 parts of microcrystal cellulose, and 0.5 to 1 part of magnesium stearate. The preparation method comprises the following steps: preparing raw materials, drying, crushing, mixing, granulating, tabletting, and the like. The hangover-alleviating tablet has excellent hangover-alleviating efficacy, but also can prevent fatty liver, cardiovascular disease, hypertension and diabetes caused by alcohol, and has efficacies for resisting allergies, alleviating the pain of alcohol allergic patients and alleviating the unfavorable symptoms caused by the alcohol.