The invention discloses a formula and a production method of hangover-alleviating soup. Raw materials comprise amomum tsao-ko, dioscorea opposita, angelica dahurica, scutellaria baicalensis, cyperus rotundus, glycyrrhiza uralensis, lonicera japonica, fructus lycii, bupleurum chinense, coptis chinensis, radix astragali, lilium brownii, syzygium aromaticum, bay leaf, pepper, rhizoma zingiberis, cinnamomum cassia, illicium verum, monosodium glutamate and refined salt. The production method comprises the main processes of material selection, drying, grinding, batching, quantification, packaging and finishing. The hangover-alleviating soup has integrated functions of tonifying liver, promoting appetite, tonifying spleen and alleviating hangover, is purely natural, does not have toxic and side effects, and is mellow in taste, rich in nutrition and applicable to being eaten in restaurants and families.