35results about How to "Lower LDL levels" patented technology

The invention relates to a preparation method and application of an Aleuritopteris argentea Fee extract. The preparation method includes: extracting Aleuritopteris argentea Fee, then performing high-speed counter-current chromatography, macroporous adsorption resin and other chromatography purification to obtain an Aleuritopteris argentea Fee extract B and an Aleuritopteris argentea Fee extract C, mixing the Aleuritopteris argentea Fee extract B with the Aleuritopteris argentea Fee extract C in certain proportion, thus obtaining the Aleuritopteris argentea Fee extract, which can be combined with a pharmaceutically acceptable carrier or other suitable excipients so as to be prepared into oral medication dosage forms according to conventional methods. The Aleuritopteris argentea Fee extract can be used for preparing drugs for preventing and treating diabetes.

The invention, in accordance with the theoretical guidance of traditional Chinese medicine prescription, provides a pharmaceutical composition of berberine and a liquorice root extract as well as berberine and glycyrrhizic acid. Compared with single administration, the pharmaceutical composition disclosed by the invention has obvious advantages in the aspect of improving blood glucose, glycated serum protein and insulin levels of a mouse with diabetics, and the pharmaceutical composition has a good synergistic effect; in the aspect of improving lipid metabolism, reducing serum glutamic pyruvic transaminase (ALT) and glutamic oxalacetic transaminase (AST) levels and the like, the pharmaceutical composition also has a good effect, and the pharmaceutical composition has a synergistic effect; and in addition, the pharmaceutical composition is capable of significantly reducing a serum total creatinine (Cre) level and is capable of effectively improving renal functions. Therefore, the pharmaceutical composition can be used for preventing and / or treating diabetics and complications thereof; and the pharmaceutical composition has positive practical significance to the development of medicine.

The invention relates to a preparation method for a Picris japonica extract and application thereof. The preparation method includes: extracting Picris japonica, conducting high speed counter current chromatography, polyamide and other chromatography purification to obtain a Picris japonica extract B and a Picris japonica extract C, and mixing the Picris japonica extract B with the Picris japonica extract C in certain proportion so as to obtain the Picris japonica extract, which can be combined with a pharmaceutically acceptable carrier or other suitable excipients so as to be prepared into oral medication dosage forms according to conventional methods. The Picris japonica extract can be used for preparing drugs for prevention and treatment of diabetes.

The invention relates to a medicinal composition for treating diabetes and its preparation method. The medicinal composition is characterized by being prepared from the following raw material drugs by weight: 8-15 parts of Berberis fruits, 4-6 parts of Spiraea alpina, 3-7 parts of lignum rhamnellae, 2-4 parts of Theloschestes flavicans, 3-5 parts of Cordia dichotoma fruits, and 2-4 parts of Aleuritopteris argentea Fee. The medicinal composition provided by the invention has good application value for treatment of diabetes.

The present invention refers to a composition and a device comprising whole blood cells for treating cholesterol disorders for use in a method comprising administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and / or abnormal HDL levels prior to treatment. Treatment with said composition and device results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly,but no more than twice per week.

The present invention provides an antigenic peptide targeting an extracellular form of CETP, but not an intracellular form of CETP, for reducing levels of LDL (including oxLDL and other derivatives of LDL) and increasing levels of HDL. Accordingly, the present invention provides a CETP vaccine for overcoming the low immunogenicity of CETP and long-term inhibition of CETP activity in order to prevent or treat oxLDL or other LDL derivative related diseases / symptoms.