31results about How to "Increased growth inhibition rate" patented technology

The invention discloses application of human ribosomal protein L23 label peptide to preparation of anti-cancer medicines. The amino acid sequence of the human ribosomal protein L23 label peptide is defined by SEQ ID NO:1. The human ribosomal protein L23 label peptide has time and dose dependence on growth inhibition rate of human breast cancer Bcap-37. The human ribosomal protein L23 label peptide at the concentrations of 0.2, 0.5 and 0.8 ug / ml has a good effect on growth inhibition of the human breast cancer Bcap-37, wherein the growth inhibition ratio of the human ribosomal protein L23 label peptide at the concentration of 0.5 ug / ml on the human breast cancer Bcap-37 is highest and reaches 72.29 percent.

The invention relates to manufacture method for anticancer active albumen in medicine technology field that the process includes: using thick sea-dragon as raw material, smashing and filtering, adding 4-12 ties alcohol water solution into the powder, vacuuming steaming and concentrating the albumen raw liquid, contacting with macroporous resin to make separating liquid, after vacuuming steaming and concentrating, adding ammiaonia sulfate powder and solving the deposit by Tris-HCl buffer solution to gain seadragon raw albuem; contacting with gel filtering medium to gain seadragon anticancer raw albumen; dissolving the raw albumen by Tris-HCl buffer solution, contacting with iron exchange medium, washing by NaCl buffer liquid. The invention has high purity, anticancer activity, and enhancing immunity.

The invention relates to a method for preparing the extract of corchorus capsularis seeds and the application of the extract. According to the method, corchorus capsularis seeds are crushed, and the petroleum ether 5 times the weight of corchorus capsularis seeds is added at the room temperature for extracting and degreasing. After the degreasing process, corchorus capsularis seeds are subjected to reflux extraction for 1-3 times in the ethanol aqueous solution 5-10 times the weight thereof, and the reflux extraction process lasts for 1-3 hours each time. The obtained extract is collected as the ethanol extract of corchorus capsularis seeds and is stored at 20 DEG C. The extract can be used for inhibiting the cell proliferation of human bladder cancer cells. Compared with the prior art, the extract is more efficient in growth proliferation effect for the human bladder cancer cell line T24 and has less influence on normal bladder epithelial cells. Therefore, the extract has an important significance on the treatment of bladder cancers, the comprehensive utilization of corchorus capsularis seed resources in China, and the increment of incomes for corchorus capsularis growers.

The invention discloses a strain of endophytic Burkholderia sp. CZ08152 in sugarcane. The classification of Burkholderia sp. CZ08152 is named as Burkholderia sp. CZ08152. The list is as shown in SEQ ID NO.1, and the depository unit is: General Microorganism Center of China Committee for Culture Collection of Microorganisms, and the deposit number is CGMCC No.5743. The invention can be applied to the production of microbial agents and bio-organic fertilizers that can promote the growth of crops, inhibit plant diseases, and improve plant resistance to adversity stress, enhance the resistance of plants to adversity stress, and play an important role in reducing the use of chemical fertilizers and pesticides and protecting the ecological environment. significance and has broad application prospects.

The invention relates to a preparation method of corchorus olitorius seed extract and application. The preparation method comprises the following steps: crushing corchorus olitorius seeds; adding petroleum ether with the weight which is 5 times as much as that of the corchorus olitorius seeds, and immersing and degreasing at a room temperature condition; after degreasing, carrying out reflowing extraction on the corchorus olitorius seeds by using an ethanol water solution with the weight which is 5-10 times as much as that of the seeds for 1-3 times, wherein each time is lasted for 1-3 hours; collecting obtained extract, namely ethanol extract of the corchorus olitorius seeds; and preserving at -20 DEG C, wherein the extract is applied to the inhibition on the proliferation of human urinary bladder cancer cells. Compared with the prior art, the inhibition on the growth of human urinary bladder cancer cell plants T24 is relatively efficient and the influences on normal urinary bladder epithelial cells are small; and the corchorus olitorius seed extract has important meanings of treating urinary bladder cancer, comprehensively utilizing jute germplasm resources of China and increasing the income of jute farmers.

The invention relates to the field of tumor DNA vaccines and virus vector vaccines with fibroblast activation protein alpha as a target, in particular to recombinant DNA carrier CpVR-FAP, recombinant adenovirus Ad-FAP and recombinant poxvirus MVA-FAP vaccines, DNA vaccines, virus vector vaccines and optimal combination of immune ways of the virus vector vaccines or application of combination of the vaccines and cyclophosphamide in preparation of anti-tumor vaccines.

The invention belongs to the field of medicine chemistry and particularly relates to a cholic acid-alpha-amino phosphonate derivative and a preparation method thereof.Cholic acid and phosphate ester serve as raw materials, and the cholic acid-alpha-amino phosphonate derivative with the following general structural formula is synthesized.This kind of compositions has good anti-tumor activity, the human hepatocellular carcinoma cell (HepG2) growth inhibition rate of some compositions is as high as 77.44%, and the advantages of the compositions are better than those of the control drug Amonafide.Please see the general structural formula in the description.