The invention discloses a piezoelectric self-power-supply positioning shoe. The piezoelectric self-power-supply positioning shoe comprises a sole and a vamp, wherein a power module, a control module, a GPS positioning module and a wireless communication module are arranged in the sole. The power module comprises a piezoelectric power generation unit and an energy storage unit. A compressive deformation region is arranged on the sole. The piezoelectric power generation unit comprises a press block and a piezoelectric body, wherein the press block makes contact with the compressive deformation region and is matched with the compressive deformation region, the piezoelectric body is driven by the press block to deform so as to generate electricity, and the piezoelectric body is fixedly arranged in the sole and connected with a circuit of the energy storage unit. Under the action of gravity of a human body, the compressive deformation region deforms, the press block which makes contact with the compressive deformation region drives the piezoelectric body to deform due to the fact that the press block relatively shifts, different electric charges are generated by the piezoelectric body in the deformation process, the electric potential difference is formed, and therefore in the process that a wearer walks, the piezoelectric body continues generating electricity, electric energy is stored in the energy storage unit, the control module, the GPS positioning module and the wireless communication module can be continuously driven to work without restriction of the time and natural conditions, and positioning information of the wearer is provided for the outside world.