40results about How to "Improves friability" patented technology

The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and / or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.

Methods of administering and pharmaceutical compositions of a biphenyl sulfonamide compound which is a dual angiotensin and endothelin receptor antagonist are disclosed for treating diseases.

A cellulose powder which has an average degree of polymerization of 150 to 450, an average particle diameter of 30 to 250 μm, an apparent specific volume exceeding 7 cm3 / g, and a retention of polyethylene glycol having a molecular weight of 400 to 190% or higher.

The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

The invention provides lipoic acid tablets with few types and small dose of accessories and a preparation method thereof. The preparation method comprises the steps of weighing filler and an adhesive, and preparing accessory tablets by a conventional tabletting process; putting the prepared accessory tablets into an efficient coating pan; weighing lipoic acid and sieving; spraying the sieved lipoic acid powder to coat the accessory tablets layer by layer by a spray gun by taking a sodium carboxymethylcellulose solution as a spray; drying and airing in a thermostatic chamber to obtain the lipoic acid tablets. The content of main drug is high, and the compliance is improved; by adopting few types and small dose of accessories, the adverse effect of the accessories is reduced, and the cost of raw materials is also reduced; the temperature of the operation process is strictly controlled, and the sticking phenomenon generated in lipoic acid tabletting is avoided by pressing the accessory tablets not containing lipoic acid; by adopting the spraying-coating process, color spots are avoided; moreover, the content uniformity, friability, chroma uniformity and stability of the lipoic acid tablets are all remarkably improved.

The invention relates to a toughening forming auxiliary of a hard capsule taking starch as a matrix for food, healthcare products, medicines and the like, and a starch hard capsule for the food, healthcare products, medicines and the like, prepared from the toughening forming auxiliary of a hard capsule taking starch as a matrix in combination with a starch matrix. The toughening forming auxiliary for preparing a hard capsule taking starch as a matrix consists of 5-50wt% of carrageenan and 50-95wt% of ghatti gum. According to the toughening forming auxiliary provided by the invention, the toughening forming auxiliary is added into the starch matrix, so that the glue-dip forming is assisted by the gelation effect of the carrageenan, and a final capsule shell is toughened by the net structure generated in gelation and a natural polysaccharide carbohydrate chain structure in the ghatti gum; meanwhile, the disintegration of the hard capsule can be effectively promoted by the good solubility and emulsifiability of the ghatti gum, thus the prepared starch hard capsule has excellent flexibility and can be quickly disintegrated.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a thyroid tablet produced by full powder direct compression and a preparation process thereof, in particular to a synergistic application of calcium hydrogen phosphate assisted optimization of thyroid raw material powder properties and freeze-drying assisted pulverization technology. The particle size of the mixed pulverized thyroid material prepared by the present invention is more than 98% below 250 μm, it is not easy to re-aggregate, and it is evenly mixed with other auxiliary materials; T in thyroid powder 3 , T 4 The RSD of content≤4%; the angle of repose of mixed powder is less than 35°, meeting the requirement of powder direct compression; T in thyroid tablets 3 and T 4 The content uniformity of A+2.2S≤20, each tablet disintegrates within 15min, and the disintegration time limit difference is small (RSD≤5%). The present invention effectively solves the problems that thyroid raw materials are not easy to be crushed and unevenly mixed with auxiliary materials, etc., optimizes the pulverization effect of thyroid raw materials, improves the powder properties of thyroid raw materials, and greatly improves the T of thyroid tablets. 3 , T 4 content uniformity.

The invention discloses a 3D printed pharmaceutical composition containing levetiracetam and a preparation method thereof. The pharmaceutical composition comprises 80%-96% levetiracetam, 2-10% disintegrant and 1.5%-5% carboxymethylcellulose sodium. The pharmaceutical composition of the present invention has high content of API, less excipients, maximum drug dosage, small volume and size of the unit composition, few surface defects of the preparation, easy oral administration, high hardness and low friability, It is beneficial to storage and transportation; the preparation method of the present invention adopts the technology of 3D extrusion printing (pressure extrusion printing), not only the prepared product has high drug loading capacity and small size, but also the process of the preparation method is simple and the production cost is low. The raw material utilization rate is high, and it is suitable for individualized production and individualized drug delivery.

The invention provides a febuxostat tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The tablet comprises 10-25 parts of febuxostat, 20-60 parts of a filler, 5-15 parts of a disintegrant, 5-10 parts of an adhesive, 1-5 parts of a lubricant, 1-3 parts of a glidant and 0.1-1 part of a synergist. In the implementation process, the specific parts of the filler and the adhesive are controlled, and the mass ratio of various components is controlled, so that the dissolution rate of the tablet is obviously improved. In the implementation process of the invention, the invention unexpectedly finds that when the mass ratio of the lubricant to the glidant is controlled to be (0.5-5):1, the smoothness of the tablet can be effectively improved,so that the obtained tablet has higher hardness and brittleness. The synergist is also added into the components disclosed by the invention, so that the stability of the tablet is obviously improved.