227results about How to "Improve the degradation problem" patented technology

Provided are siRNA molecules of between about 15 base-pairs and about 40 base-pairs comprising one or more universal-binding nucleotide such as inosine, 1-β-D-ribofuranosyl-5-nitroindole, and 1-β-D-ribofuranosyl-3-nitropyrrole, compositions comprising one or more universal-binding nucleotide comprising siRNA, and methods for making and for using such universal-binding nucleotide comprising siRNA molecules to increase the specific binding of the modified siRNA molecule to variants of a target sequence such as, for example, when in contact with a biological sample and to reduce off-target effects of the siRNA molecule.

Implantable medical articles having a coating formed of hydrophobic derivatives of natural biodegradable polysaccharides are described. The coatings can include a bioactive agent, and demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The coated implantable medical articles can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.

The present invention provides methods and compositions for enhancing recovery in a subject suffering from damage to the nervous system. In particular, the invention includes a method for promoting recovery and / or reorganization in the nervous system of a subject in need of enhancement of recovery and / or reorganization of the nervous system as a result of ischemic, hemorrhagic, neoplastic, degenerative, or traumatic damage by focally administering a composition comprising a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor to the nervous system of the subject. In some embodiments an additional active agent is also administered. The composition can be delivered using a variety of techniques including injection, via infusion pump, from an implantable microchip, or using a polymeric delivery vehicle. The composition can be administered, for example, to one or more subdivisions or areas of the brain, the spinal cord, or to one or more nerves or nerve tracts innervating diverse regions of the body. The invention also includes a drug delivery device for implantation into the nervous system to promote nervous system reorganization and / or recovery following ischemic, hemorrhagic, neoplastic, traumatic or degenerative damage, the drug delivery device comprising a biocompatible polymer and a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor, wherein the proteolysis-enhancing agent is released from the polymer in an amount effective to promote structural reorganization of the nervous system. In some embodiments the biocompatible polymer is a hydrogel.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

A method of degrading a plastic in the presence of a biosurfactant; a method of degrading a plastic by contacting the plastic with a microorganism; a process for producing a useful substance from a plastic which comprises degrading the plastic by contacting the plastic with a microorganism and further converting the components of the thus degraded plastic with the use of a microorganism; a method of degrading a plastic by contacting the plastic with a microorganism in the coexistence of a biosurfactant and / or a plastic-degrading enzyme and thus degrading the plastic under the action of the microorganism; a transformant microorganism having been recombined with at least one DNA selected from among a DNA containing a gene encoding a surface active substance, a DNA containing a gene encoding a plastic-degrading enzyme and a DNA containing a gene encoding a useful substance; novel genes as described above; and proteins encoded thereby.

This invention relates to soil conditioner, fertilizer and fungicide compositions. In particular it relates to soil conditioner, fertilizer and fungicide compositions that utilizes by-products from brewing processes, and especially made from malt extract or spent grain liquor. The invention also relates to methods of manufacturing soil conditioners, fertilizers and fungicides.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The invention relates to a preparation method of a petroleum degrading bacteria solid inoculant. The preparation method comprises the following steps: A, screening and domestication of the petroleum degrading bacteria; B, preparation of a seed culture solution; C, fermentation of the solid inoculant; and D, drying, pulverization, measurement and packaging of composted products. The petroleum degrading bacteria solid inoculant has the beneficial effect of improving the petroleum dissolution effect by taking a nonionic surfactantpolysorbate-80 (tween 80) as a solubilizer. The preparation method has the advantages that solid fermentation raw materials are easy to get and the process is relatively simple; and the solid inoculant contains a large amount of carbon and nutrient elements so as to provide more proper matrix for the growth of the bacteria, has strong affinity for the microorganisms, has immobilization efficiency, is capable of improving the competitiveness and degrading efficiency of the added microorganisms and indigenous microorganisms, and is convenient to transport and operate agriculturally and suitable for the large-scale in-situ biological remediation of the petroleum-polluted soil.

A multi-layer bioactive and biodegradable film. The multi-layer film includes one or more bioactive compounds or microorganisms for promoting growth and health of a plant, the bioactive compounds or microorganisms contained between layers of the film, wherein each one of the layers comprises about 60% to about 75% (m / m) polyhydroxyalkanoate. The bioactive compounds or microorganisms may include any one of or a combination of: a metabolite, an anti-microbial compound, an enzyme, a live microorganism, a fertilizer, a plant growth hormone, a preservative, a pesticide or an herbicide. Release of one or more bioactive compounds may be achieved in a timed and controlled manner.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The invention provides a multi-resistant nutrient for plant growth and a preparation method of the multi-resistant nutrient for plant growth. The multi-resistant nutrient comprises the components in parts by weight as follows: 6-10 parts of compound amino acids, 0.5-1.5 parts of mushroom protein polysaccharide, 0.5-1.5 parts of water soluble chitosan, 2-4 parts of zinc sulfate, 1-3 parts of boric acid and 90-180 parts of water. The preparation method comprises the steps of: heating part of water and dissolving zinc sulfate and boric acid; then heating the residual water and dissolving compound amino acids, mushroom protein polysaccharide and water soluble chitosan; then heating while agitating, and uniformly mixing with zinc sulfate and boric acid; and cooling after insulating so as to obtain the multi-resistant nutrient for plant. The multi-resistant nutrient for plant is rich in various amino acid trace elements which prompt growth of the plant, has remarkable effects of enhancing the immunologic function of the plant and preventing diseases and insect pests, has various biological adjusting functions, and is stress resistant, cold resistant, draught resistance and prevents diseases and insect pests.

The invention relates to remediation of heavy metal pollution in the environment, in particular to a method of restoring soil polluted by heavy metal, which belongs to the field of environmental pollution remediation. The method is characterized in that a root system of ciliate desert-grass is used for absorbing arsenic from the soil, the arsenic from the soil is stored in leaves to ensure that the content of arsenic in the leaves of the ciliate desert-grass reaches 0.5-0.8 %, the leaves of the ciliate desert-grass are removed periodically, the underground part is reserved, and arsenic transportation and transfer can be performed continuously, so that the purpose of lowering the content of arsenic in the soil is achieved. The method has the benefits that the method is low in cost and high in restoring efficiency, simplifies the soil restoring procedure and is suitable for popularization and application; the harvested leaves are subjected to safe landfill or incineration concentratedly; no secondary pollution is generated; the diversity of soil organisms is restored and improved; a new plant resource variety is developed for a plant for restoring the soil polluted by the heavy metal; and a new advancement and development space is brought to the deep development of a plant restoring technology.

A method is disclosed for treating superficial venous pathology in a patient. The method comprises the steps of: (a) percutaneously piercing a vein to be treated; and (b) directing intense pulse or laser light at the patient's skin predominantly within the area of skin manifesting physical, chemical and / or color changes caused by step (a). In a preferred method sclerotherapy is performed on the vein to be treated and then laser light is directed at the patient's skin substantially entirely within the area of skin manifesting the changes.

The invention discloses a method for continuously repairing a heavy metal in soil by using a chelating agent, which is characterized by comprising the following steps of: planting ramie into soil to be treated; after the survival of the plant, adding a coated EDTA chelating agent accounting for 0.05 to 0.5 percent of the weight of the soil into the soil; and continuously and periodically harvesting the overground part of the plant so that the underground part can grow continuously to be harvested circularly. The diameter of the EDTA granules of the coated EDTA chelating agent is 0.5 to 2mm; and the coating is an inorganic layer with the thickness of 0.25 to 0.35mm or an organic layer with the thickness of 0.30 to 0.40mm. In the repairing method, the coated EDTA chelating agent with proper coating thickness is selected to enable the releasing efficiency to be organically matched with the growth period of the ramie, enhance the repairing capacity of the soil and reduce the environmental risk of the chelating agent.

A compostable tie is disclosed. In some forms, the tie may have an aperture at the tail end sized and shaped to facilitate insertion of the tail into the head and use of the tie.

A process for eliminating the pollution of Pb, Zn and Cd to said and water by use of arabis paniculata features that the Arabis paniculata is planted in the polluted sol or water for absorbing Pb, Zn and Cd. When their concentrations in the plant reach a certain value, the plant on the ground is cut out and its root is retained for growing the plant no the ground and further cutting it out.

The invention relates to a method for rehabilitating uranium contaminated soil by use of a functional plant community. According to the method, broussonetia papyrifera and Ilex cornuta, and reed, Pteris multifida Poir and difformed galingale herb (herbaceous plants), which can enrich uranium in the soil are selected to construct a stable plant community with a function of in-situ repairing for uranium contaminated soil, wherein all plants in the plant community can enrich uranium in the uranium contaminated soil and can transport the uranium into an overground part of the plants, thereby achieving the purpose of rehabilitating the uranium contaminated soil. The method comprises the following steps of firstly, performing seed treatment and sowing; secondly, trimming and fertilizing; thirdly, harvesting; and fourthly, treating in a concentrating manner. The method does not need other auxiliary means and is capable of overcoming the disadvantages that the plant species structure is simple, the plant community is instable and easy to degrade, the maintenance cost is high, the plant diseases and insect pests are more and the ecological functions are at a low level when the single plant species is used for repairing the uranium contaminated soil in an existing method, the five plants have synergistic effect, and the repairing efficiency is improved remarkably compared with that of the method adopting the single plant species for rehabilitating the uranium contaminated soil.

Laser apparatus and methods that permit actuation of a tuning element via a magnetically coupled drive assembly, and which provide for isolation of contamination-sensitive optical surfaces within a hermetically sealed enclosure with a magnetically coupled drive assembly that is external to the enclosure. The apparatus of the invention comprises a tuning element positioned in a light beam, and a drive element magnetically coupled to the tuning element. The apparatus may further comprise a hermetically sealed enclosure, with the tuning element positioned within the hermetically sealed enclosure, and the drive element located outside the hermetically sealed enclosure. The methods comprise positioning a tuning element in a light beam, magnetically coupling a drive element to the tuning element; and actuating the tuning element via magnetic coupling between the tuning element and the drive element. The methods may further comprise enclosing the tuning element in a hermetically sealed container.

The invention belongs to an image binarization processing method and relates to an adaptive threshold binarization method for two-dimensional barcodes. The adaptive threshold binarization method for the two-dimensional barcodes comprises the steps of 1.1) dividing a barcode image into a plurality of areas with the same size and calculating the average gray value of each area; 1.2) calculating the harmonic factor of each area and calculating the corresponding threshold by using the harmonic factor of each area; and 1.3) binarizing pixels in each area by using the corresponding threshold. The adaptive threshold binarization method for the two-dimensional barcodes has the advantages that not only can the speed of a local threshold binarization algorithm be improved, but also the threshold of each area can be dynamically and adaptively calculated, the blocking effect is enabled to disappear, the boundaries among areas can be well fused by using the harmonic factor of each area and the pseudo-boundary is well degenerated.

Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and / or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and / or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.

The present invention provides a new type wireless chip that can be used without being fixed on a product. Specifically, a wireless chip can have a new function by a sealing step. One feature of a wireless chip according to the present invention is to have a structure in which an integrated circuit is sealed by films. In particular, the films sealing the integrated circuit have a hollow structure; therefore the wireless chip can have a new function.

The present invention provides a display device having high image quality and high resolution, a driving method thereof, and an element substrate. Also, the present invention provides a display device having improved degradation of light emitting elements, a driving method thereof, and an element substrate. The display device of the present invention has a first transistor, a second transistor, a third transistor, a light emitting element, a source driver, a first gate driver, and a second gate driver. A gate electrode of the first transistor is connected to a gate line, one of a source electrode and a drain electrode thereof is connected to a source line, and the other is connected to a gate electrode of the third transistor. The light emitting element, the second transistor and the third transistor are connected in series between the first power source and the second power source. The gate electrode of the second transistor is connected to a third power supply, the source driver is connected to the source line, and the first gate driver and the second gate driver are connected to the gate line.

This invention relates to soil conditioner, fertilizer and fungicide compositions. In particular it relates to soil conditioner, fertilizer and fungicide compositions that utilizes by-products from brewing processes, and especially made from malt extract or spent grain liquor. The invention also relates to methods of manufacturing soil conditioners, fertilizer and fungicides.

A novel, new, and highly effective agent for promoting fat degradation that contains astaxanthin and / or an ester thereof as active ingredient is provided. The agent for promoting fat degradation of the present invention has an effect of reducing fat by lipolysis of fat in either a subject who is in a condition in which fat has already accumulated or a subject who is in a condition in which fat has not yet been accumulated. Accordingly, the agent for promoting fat degradation of the present invention can restore hypertrophied adipocytes to a normal size.

The invention relates to phytoremediation technology for treating polluted environment, in particular to a method for repairing and treating the earth polluted by cadmium by using a flower plant, namely maidenhair. The method utilizes root systems of the cadmium ultra-enriched flower maidenhair to absorb the enriched cadmium in the polluted earth in large amount, transfers the cadmium upward to the overground part; when plants grow to the height of between 30 and 40 centimeters or the blossom time, the plants are integrally removed and sold as commercial ornamental flowers or properly treated so as to absorb and remove a large amount of the cadmium from the earth; and by repeatedly planting the flower plant and repeating the process, excessive cadmium in the polluted earth can be continuously extracted until the content of the cadmium achieves the environment safety standards. The method has the advantages of small engineering quantity, no destruction to physicochemical property of the earth, no secondary pollution, beatifying environment while treating the polluted earth, and the like.