227results about How to "Improve the degradation problem" patented technology

Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The present invention provides methods and compositions for enhancing recovery in a subject suffering from damage to the nervous system. In particular, the invention includes a method for promoting recovery and / or reorganization in the nervous system of a subject in need of enhancement of recovery and / or reorganization of the nervous system as a result of ischemic, hemorrhagic, neoplastic, degenerative, or traumatic damage by focally administering a composition comprising a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor to the nervous system of the subject. In some embodiments an additional active agent is also administered. The composition can be delivered using a variety of techniques including injection, via infusion pump, from an implantable microchip, or using a polymeric delivery vehicle. The composition can be administered, for example, to one or more subdivisions or areas of the brain, the spinal cord, or to one or more nerves or nerve tracts innervating diverse regions of the body. The invention also includes a drug delivery device for implantation into the nervous system to promote nervous system reorganization and / or recovery following ischemic, hemorrhagic, neoplastic, traumatic or degenerative damage, the drug delivery device comprising a biocompatible polymer and a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor, wherein the proteolysis-enhancing agent is released from the polymer in an amount effective to promote structural reorganization of the nervous system. In some embodiments the biocompatible polymer is a hydrogel.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

This invention relates to soil conditioner, fertilizer and fungicide compositions. In particular it relates to soil conditioner, fertilizer and fungicide compositions that utilizes by-products from brewing processes, and especially made from malt extract or spent grain liquor. The invention also relates to methods of manufacturing soil conditioners, fertilizers and fungicides.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The invention provides a multi-resistant nutrient for plant growth and a preparation method of the multi-resistant nutrient for plant growth. The multi-resistant nutrient comprises the components in parts by weight as follows: 6-10 parts of compound amino acids, 0.5-1.5 parts of mushroom protein polysaccharide, 0.5-1.5 parts of water soluble chitosan, 2-4 parts of zinc sulfate, 1-3 parts of boric acid and 90-180 parts of water. The preparation method comprises the steps of: heating part of water and dissolving zinc sulfate and boric acid; then heating the residual water and dissolving compound amino acids, mushroom protein polysaccharide and water soluble chitosan; then heating while agitating, and uniformly mixing with zinc sulfate and boric acid; and cooling after insulating so as to obtain the multi-resistant nutrient for plant. The multi-resistant nutrient for plant is rich in various amino acid trace elements which prompt growth of the plant, has remarkable effects of enhancing the immunologic function of the plant and preventing diseases and insect pests, has various biological adjusting functions, and is stress resistant, cold resistant, draught resistance and prevents diseases and insect pests.

The invention relates to remediation of heavy metal pollution in the environment, in particular to a method of restoring soil polluted by heavy metal, which belongs to the field of environmental pollution remediation. The method is characterized in that a root system of ciliate desert-grass is used for absorbing arsenic from the soil, the arsenic from the soil is stored in leaves to ensure that the content of arsenic in the leaves of the ciliate desert-grass reaches 0.5-0.8 %, the leaves of the ciliate desert-grass are removed periodically, the underground part is reserved, and arsenic transportation and transfer can be performed continuously, so that the purpose of lowering the content of arsenic in the soil is achieved. The method has the benefits that the method is low in cost and high in restoring efficiency, simplifies the soil restoring procedure and is suitable for popularization and application; the harvested leaves are subjected to safe landfill or incineration concentratedly; no secondary pollution is generated; the diversity of soil organisms is restored and improved; a new plant resource variety is developed for a plant for restoring the soil polluted by the heavy metal; and a new advancement and development space is brought to the deep development of a plant restoring technology.

The invention discloses a method for continuously repairing a heavy metal in soil by using a chelating agent, which is characterized by comprising the following steps of: planting ramie into soil to be treated; after the survival of the plant, adding a coated EDTA chelating agent accounting for 0.05 to 0.5 percent of the weight of the soil into the soil; and continuously and periodically harvesting the overground part of the plant so that the underground part can grow continuously to be harvested circularly. The diameter of the EDTA granules of the coated EDTA chelating agent is 0.5 to 2mm; and the coating is an inorganic layer with the thickness of 0.25 to 0.35mm or an organic layer with the thickness of 0.30 to 0.40mm. In the repairing method, the coated EDTA chelating agent with proper coating thickness is selected to enable the releasing efficiency to be organically matched with the growth period of the ramie, enhance the repairing capacity of the soil and reduce the environmental risk of the chelating agent.

Methods, compositions and kits for masking and subsequent removal of oil, grease, rust and other stains from a variety of rough solid surfaces, including, but not limited to stone, concrete, asphalt, stucco brick, and ceramic. The methods include coating the stains with an opaque or translucent thin film of a composition that makes the stain practically indistinguishable against the background, exposing the coated stain to the elements, such as, sunlight, air, moisture, resulting in spontaneous transformation, degradation and subsequent removal of the stains from the solid surfaces. The compositions include a photocatalyst by itself or the photocatalyst combined with at least one of, a sensitizer, a dopant, a mediator, a co-reagent, a pigment and a binder. The role of a photocatalyst is to produce highly reactive species or radicals and initiate the degradation of a stain upon exposure to elements, such as, sunlight, air and ambient humidity. Artificial light sources can be used instead of sunlight.

Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and / or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and / or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.

This invention relates to soil conditioner, fertilizer and fungicide compositions. In particular it relates to soil conditioner, fertilizer and fungicide compositions that utilizes by-products from brewing processes, and especially made from malt extract or spent grain liquor. The invention also relates to methods of manufacturing soil conditioners, fertilizer and fungicides.

The invention relates to phytoremediation technology for treating polluted environment, in particular to a method for repairing and treating the earth polluted by cadmium by using a flower plant, namely maidenhair. The method utilizes root systems of the cadmium ultra-enriched flower maidenhair to absorb the enriched cadmium in the polluted earth in large amount, transfers the cadmium upward to the overground part; when plants grow to the height of between 30 and 40 centimeters or the blossom time, the plants are integrally removed and sold as commercial ornamental flowers or properly treated so as to absorb and remove a large amount of the cadmium from the earth; and by repeatedly planting the flower plant and repeating the process, excessive cadmium in the polluted earth can be continuously extracted until the content of the cadmium achieves the environment safety standards. The method has the advantages of small engineering quantity, no destruction to physicochemical property of the earth, no secondary pollution, beatifying environment while treating the polluted earth, and the like.

An improved method of preventing carryover contamination of an amplification reaction involves treating uracil-containing DNA with uracil-N-DNA glycosylase and heating the DNA in the presence of polyamines, such as spermidine, spermine and the like. Alternatively, after treatment with uracil-N-DNA glycosylase, the reaction is further incubated with an enzyme having AP lyase activity.