100results about How to "Improve sensitivity and specificity" patented technology

The present invention provides a reagent and a method of safely, conveniently, and specifically diagnosing Crohn's disease. Provided are a diagnostic method for Crohn's disease in a subject, including measuring antibodies against one kind or more of dietary components selected from the group consisting of grapefruit, alfalfa, avocado, cabbage, green pepper, lettuce, onion, potato (white), spinach, tomato, oat, pecan, yeast, cane sugar, celery, buckwheat, corn, rice and soy, and a diagnostic reagent or kit for Crohn's disease, containing the above-mentioned preparation of a dietary component.

The present invention is directed toward an acoustic, piezoelectric, electric, electro-mechanical or pneumatically driven surface drum driver, in mechanical engagement with a biopsy or acupuncture needle device and a method for its use for diagnosis of small e.g. 100 microns, tumors via the production of magnetic resonance elastographic images (MRE), without artifact production, in a magnetic resonance imaging (MRI) machine. In a second embodiment, the invention is directed toward an acoustically, pneumatically, piezoelectrically, electrically and / or electro-mechanically driven acupuncture needle, useful for simulating manual single-needle acupuncture treatments via a non-manually manipulated acupuncture needle; and further to a device and process for determination, using twin pneumatically driven surface drivers, of organ stiffness, e.g. brain stiffness, which can be quantified so as to be useful in elucidating and quantifying brain cognitive state, e.g. normal, mild cognitive impairment (MCI) or Alzheimer's dementia (AD).

Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.

The invention discloses a chromatographic test paper strip which is applied to glycosylated hemoglobin detection. The chromatographic test paper strip comprises a bottom plate, a sampling area for bearing a sample is arranged at one end of the bottom plate, and an attracting area for providing chromatographic power is arranged at the other end; a chromatographic reaction area is formed between the sampling area and the attracting area; a first test line close to the sampling area and a second test line close to the attracting area are sequentially arranged in the chromatographic reaction area; the first test line coats a glycosylated hemoglobin monoclonal antibody; the second test line coats the glycosylated hemoglobin monoclonal antibody. A detection method disclosed by the invention combines the advantages of an immunochromatography and an affinity chromatography; through the detection by the test paper strip with a simple structure and the calculation on the content of the glycosylated hemoglobin, not only are the sensitivity and the specificity of a traditional chromatography improved, but also the detection method is combined with the affinity chromatography, so that the operation is simple and convenient.

Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.