295results about How to "Improve localization" patented technology

Disclosed are devices and methods for detecting, preventing, and / or treating neurological disorders. These devices and methods utilize electrical stimulation, and comprise a unique concentric ring electrode component. The disclosed methods involve the positioning of multiple electrodes on the scalp of a mammal; monitoring the mammal's brain electrical patterns to identify the onset of a neurological event; identifying the location of the brain electrical patterns indicative of neurological event; and applying transcutaneous or transcranial electrical stimulation to the location of the neurological event to beneficially modify brain electrical patterns. The disclosed methods may be useful in the detection, prevention, and / or treatment of a variety of indications, such as epilepsy, Parkinson's Disease, Huntington's disease, Alzheimer's disease, depression, bipolar disorder, phobia, schizophrenia, multiple personality disorder, migraine or headache, concussion, attention deficit hyperactivity disorder, eating disorder, substance abuse, and anxiety. The disclosed methods may also be used in combination with other peripheral stimulation techniques.

The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.

A method for providing location-based nowcast, comprises the steps of: a) initiation of a request, by an end-user, for a time evolution of user-selected nowcast weather parameters, the transmission of the request being made over a public communication network to a nowcast request processor; b) the determination of the end-user's actual location by the nowcast request processor; c) the nowcast request processor gathering raw weather data from data sources; d) processing the raw data into a time-series of nowcast parameter maps; e) extracting the time evolution of the user requested nowcast parameters from the time-series of nowcast parameter maps by positioning the end-user's location on said time series; and f) distributing the requested information to end-user regarding the user-selected nowcast parameters within the extracted time evolution.

The instant invention is based, at least in part on the finding that binding molecules which bind to different epitopes within IGF-1R result in improved IGF-1 and / or IGF-2 blocking capabilities when compared to binding molecules that bind to a single IGF-1R epitope. The instant invention provides compositions that bind to multiple epitopes of IGF-1R, for example, combinations of monospecific binding molecules or multispecific binding molecules (e.g., bispecific molecules). Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize IGF-1R signaling are also provided.

A desired acoustic signal is extracted from a noisy environment by generating a signal representative of the desired signal with a processor. The processor receives aural signals from two sensors each at a different location. The two inputs to the processor are converted from analog to digital format and then submitted to a discrete Fourier transform process to generate discrete spectral signal representations. The spectral signals are delayed by a number of time intervals in a dual delay line to provide a number of intermediate signals, each corresponding to a different spatial location relative to the two sensors. Locations of the noise source and the desired source are determined and the spectral content of the desired signal is determined from the intermediate signal corresponding to the noise source locations. Inverse transformation of the selected intermediate signal followed by digital to analog conversion provides an output signal representative of the desired signal. Techniques to localize multiple acoustic sources are also disclosed. Further, a technique to enhance noise reduction from multiple sources based on two-sensor reception is described.

This invention presents a device, and the method it implements, which is an improvement in the design of nerve stimulators. Like conventional stimulators, it uses a percutaneous, insulated needle for the performance of therapeutic interventions targeting nerves. The improvement comprises offering an option for either constant current or constant voltage, offering a choice of waveform parameters, controlling a pulse generator, supplying a second background waveform, measuring the current and voltage applied to the tissue, computing further electrical characteristics, dynamically adjusting circuit components to ensure a desirable waveform applied to the tissue, and displaying measured and computed electrical characteristics of the tissue. The object is improved positioning of a needle tip near a nerve or nerve plexus for regional anesthesia, pain management, and other medical purposes.

The present invention is directed to a method of applying radiation through an optical fiber for detecting disease within a plant or animal or imaging a particular tissue of a plant or animal. In addition, fluorescence can be detected and localized within a subject by such application of radiation through an optical fiber. The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle to evaluate sub-surface tissue, or with an endoscope to evaluate tissue within body cavities.

The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.

The present invention is directed to delivery and retention of active agents to targeted lymph nodes in a mammal using a ligand / anti-ligand pair. More particularly, the invention involves methods, compositions, and kits for delivery and retention of active agents to targeted lymph nodes using compositions comprising a ligand-colloid moiety and compositions comprising an anti-ligand. Active agents may be associated with one or more of the colloid, ligand, or anti-ligand. Conjugation of the ligand and anti-ligand after administration permits retention of aggregated colloid complex in targeted lymph nodes.

Method and system for generating output signals for reproduction by two physical speakers in response to input audio signals indicative of sound from multiple source locations including at least two rear locations. Typically, the input signals are indicative of sound from three front locations and two rear locations (left and right surround sources). A virtualizer generates left and right surround outputs useful for driving front loudspeakers to emit sound that a listener perceives as emitting from rear sources. Typically, the virtualizer generates left and right surround outputs by transforming rear source inputs in accordance with a head-related transfer function. To ensure that virtual channels are well heard in the presence of other channels, the virtualizer performs dynamic range compression on rear source inputs. The dynamic range compression is preferably accomplished by amplifying rear source inputs or partially processed versions thereof in a nonlinear way relative to front source inputs.

The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and / or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of the tumor cell and tumor-associated endothelial cell to therapeutic levels of the agent for a longer period of time as compared to other delivery systems. The present invention also describes pharmaceutical compositions comprising the delivery systems of the present invention. The present invention further relates to a tumor treatment comprising an increased amount of therapeutic agent delivered by the system of the present invention as compared to other delivery systems. The delivery systems and pharmaceutical compositions can be administered to a subject, preferably a human, alone or in combination, sequentially or simultaneously, with other prophylactic or therapeutic agents and / or anti-cancer treatments.

The present invention relates to an ultrasonic and electrolytic combined microfine machining method and its equipment. Said invention can make ultrasonic machining method and electrolytic machining method be organically combined together to implement machining of microdevice. Said equipment includes the following several portions: electrolyzer, ultrasonic vibration drive device, working table, micropressure regulation and Z-direction automatic feeding measurement device and electrolytic current measurement analysis device. Besides, said invention also provides the working principle and concrete steps of said method.

A method of determining a position and orientation of a device is provided. The position and orientation of the device is determined based on multiple degrees of freedom (DoF) and the device is associated with a capturing device for capturing at least one image is provided. The method includes: capturing at least one image of a real object with the capturing device, and providing a coordinate system in relation to the object; providing an estimation of intrinsic parameters of the capturing device; providing pose data to compute first and second DoFs in the coordinate system, with each DoF having a confidence degree; determining an initial pose of the device; performing a pose estimation process, and calculating in the pose estimation process an estimation of the DoFs having a second confidence degree; and determining a position and orientation of the device.

A method for localizing one or more sound sources of interest placed within a sound environment comprising ambient noise by estimating the directions of arrival (θ,φ) of said one or more sound source of interest comprising the steps of: calculating the environment steered response power (SRP (t, f, θ, φ)) corresponding to the steered response power of said one or more source of interest for one or more orientations using said environment audio signals; obtaining, using said array of at least two microphones, noise audio signals corresponding to the audio signals emanating from said sound environment under particular reference conditions; calculating a noise steered response power (SRPn (t, f, θ, φ)) corresponding to the steered response power of the ambient noise for said one or more orientations using said noise audio signals; and estimating the direction of arrival of said sound source of interest.

The present invention comprises methods and compositions for the treatment or alleviation of NAFLD (non-alcoholic fatty liver disease) and those conditions associated with NAFLD, including fatty liver disease, nonalcoholic steatohepatitis (NASH) and cirrhosis through the use of pharmaceutical formulations of lysosomal acid lipase or related proteins and / or polypeptides. This invention is also directed to a combination therapy treatment for treating The Metabolic Syndrome. As part of a combination therapy regime for the treatment of The Metabolic Syndrome, pharmaceutical formulations of lysosomal acid lipase or related proteins and / or polypeptides are used as part of the combination therapy regime for treating NAFLD (and NASH), which comprises one of the conditions constituting The Metabolic Syndrome,

The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

The disclosed invention is a unique, patient-friendly, laser-based tumor ablation system for the removal of malignant tumors of the prostate and, with modified delivery systems, may have application for other areas of the human body.The disclosed invention is an integrated, robotic treatment subsystem that takes advantage of the capabilities of the previously disclosed MedSci Detection, Mapping and Confirmation System, for the purpose of providing a patient friendly system and method for removing tumors detected by said diagnostic system. The invention is a laser-based endosurgical thermal treatment system that utilizes historical cancer mapping data together with real-time ultrasonic and other data to reliably target and control the eradication of cancer conditions. The system contains computer aided robotic control such that control of the boundary, size, position and orientation of the ablated volume of tissue has a tolerance of less than a millimeter. The disclosed system provides multimodal scanning methods for improved identification and localization of detected tumors, including multi-focal tumors. The disclosed system also provides multiple methods for monitoring the successful progress and conclusion of the treatment. The disclosed system provides the capability of closing the created cavity. The disclosed system resides in a subsystem module and when treatment is to be conducted, the treatment module is substituted in place of the previously disclosed ultrasonic diagnostic module of the MedSci system. The subject thermal treatment system meets the challenges confronting the advancement of thermal treatment systems in the search for a highly effective and patient-friendly cancer treatment.

Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for a population of cells of a mammal comprises steps of administering to said mammal an adequate dosage of blocking antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, and administering to said mammal an effective dosage of said antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for said population of cells. In the preferred embodiment, the specific antibodies are monoclonal antibodies directed toward tumor-associated antigen in man.

The invention relates to a micro-hole group electrolytic machining method and a bipolar electrode thereof, which adopts a bipolar electrode and belongs to the technical field of electrolytic machining. The invention is characterized in that the method includes the following steps: (a) manufacturing a bipolar electrode (1) provided with a through hole group structure and consists of an auxiliary anode (7), an insulated layer (6) and a tool cathode (5); (b) tightly binding the auxiliary anode (7) with a workpiece anode (2) on the bipolar electrode; (c) connecting the workpiece anode (2) and the tool cathode (5) with the anode and the cathode of the electrical source (3) respectively; (d) spraying electrolyte (4) on the surface of the tool cathode (5) in the way that the electrolyte runs through the through hole group of the bipolar electrode (1) to reach the surface of the workpiece anode (2); (e) connecting the electrical source (3) for electrolytic machining. The invention can significantly improve the localization and micro-scale processing capacity of electrolytic machining.

Electrically programmable integrated fuses are provided for low power applications. Integrated fuse devices have stacked structures with a polysilicon layer and a conductive layer formed on the polysilicon layer. The integrated fuses have structural features that enable the fuses to be reliably and efficiently programmed using low programming currents / voltages, while achieving consistency in fusing locations. For example, programming reliability and consistency is achieved by forming the conductive layers with varied thickness and forming the polysilicon layers with varied doping profiles, to provide more precise localized regions in which fusing events readily occur.

The instant invention describes novel multispecific binding molecules comprising synthetic connecting peptides. The synthetic connecting peptides result in the preferential synthesis of multispecific binding molecules comprising polypeptide chains that are linked via at least one interchain disulfide linkage. In addition, the invention pertains to compositions in which a majority of the multispecific binding molecules comprising polypeptide chain that are linked via at least one interchain disulfide linkage or are not linked via at least one intrachain disulfide linkage. In a specific embodiment, the invention pertains to compositions comprising multispecific dimeric binding molecules said molecules comprising at least a first binding site specific for a tumor necrosis factor (TNF) receptor or a ligand of a TNF receptor family member and at least a second binding site; and at least two polypeptide chains comprising at least one heavy chain portion and a synthetic connecting peptide; wherein greater than about 50% of the dimers comprise polypeptide chains that are linked via at least one interchain disulfide linkage.

Transrectal ultrasound guided transperineal low dose-rate brachytherapy has been emerged as one of the definitive treatments of low-risk prostate cancer. Ultrasound has been an excellent tool in guiding the implant needles with respect to prostate anatomy, yet it cannot show reliably the location of radioactive seeds after they are released in the prostate. Intraoperative C-arm fluoroscopy can show the implanted seeds, but it cannot detect prostate anatomy. Intra-operative fusion of these two complementary modalities offers significant clinical benefit by allowing for real-time optimization of the brachytherapy implant as the procedure progresses in the operating room. Disclosed is a system and method for mitigating this problem and providing registration of seeds seen by fluoroscopy with live prostate anatomy visualized by transrectal ultrasound.

A system and method for 3D microfabrication projects light capable of initiating photopolymerization toward a spatial light modulator that modulates light responsive to digital masks corresponding to layers of the structure. Projection optics focus the modulated light onto an optical plane within a photopolymerizable material supported on a stage. A computer controller causes the spatial light modulator to project a sequence of images corresponding to the digital masks while coordinating movement of the stage to move a position of the optical plane within the photopolymerizable material to sequentially project each image of the sequence to generate the structure by progressively photopolymerizing the photopolymerizable material.