The invention provides a salt-resistance Bacillusmethylotrophicus strain LJ and an application thereof. The salt-resistance Bacillusmethylotrophicus strain LJ is classified to be named as Bacillusmethylotrophicus, and the collection number of the salt-resistance Bacillusmethylotrophicus strain LJ is CGMCCNO.7570. By performing salt tolerance analysis on the salt-resistance Bacillusmethylotrophicus strain LJ, performing a pathogenicity test on crops, and performing a test on the inhibition effect of the strain on pathogenic bacteria, results show that the salt tolerance degree of the strain is 25-30%; the strain can not cause pathogenicity to the crops, has relatively ideal inhibition effects on bacterial diseases, viral diseases and fungous diseases of tobaccos, can be compounded with a great number of elements, is long in retention period and high in effective bacterium survival rate, can be applied to saline-alkali soils, and has the effects of improving the soil, resisting the diseases, increasing the yield and the like. The salt-resistance Bacillusmethylotrophicus strain LJ disclosed by the invention ensures that a microbial preparation has the positive effects of preventing the diseases and promoting the growth of plants in special environments; the microbial inoculum has the effects of salt-resistant growth-promoting bacteria and disease-prevention growth-promoting bacteria, and is suitable for improvement of salt marsh, alkali soil and acid soil.