The invention discloses a formula and a production method of ganoderma lucidum blood-circulation-activating stasis-dissipating wine. Ganoderma lucidum, vervain, polygonum cuspidatum, ningpo yam rhizome, centella asiatica, ligusticum chuanxiong hort, carthamus tinctorius, frankincense, trogopterus dung, rhizoma drynariae, fibraurea recisa, garden balsam, concha arcae, radix ranunculi ternati and kelp are used as main raw materials. The production method of the wine mainly includes the technological processes of material selecting, drying, dispensing, steeping, packaging and product finishing and the wine has the effects of nourishing the heart, soothing nerves, activating blood circulation, dissipating stasis, expelling wind, eliminating dampness, promoting blood circulation, relieving pain and the like. In addition, according to the formula and the production method of the ganoderma lucidum blood-circulation-activating stasis-dissipating wine, the ganoderma lucidum blood-circulation-activating stasis-dissipating wine is delicious in taste, convenient to use, purely natural, free of poison and side effects, and suitable for being drunk in restaurants and houses.