55 results about "Pressure overload" patented technology

The present invention identifies genes whose gene products are differentially expressed pressure overload of the heart. The invention provides methods for diagnosing or assessing an individual's susceptibility to heart failure from many etiologies, as well as the presence and severity of hypertrophy, chamber enlargement, or systolic heat failure. Also provided are therapeutic methods for treating a heart patient or methods for prophylactically treating an individual susceptible to heart failure. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered a heart attack or are at risk of heart failure.

The invention discloses a device and method for stabilizing annulus pressure of an oil sleeve. The method comprises the following steps that the annulus pressure of the oil sleeve is balanced through the pressure difference which are formed between an intelligent pumping system and an intelligent pressure relief system and by superimposing the pressure of an annulus-protection-liquid liquid column, when the annulus pressure is too high, a pressure relief valve is automatically opened owing to pressure overload, and redundant liquid or gas in an annulus is exhausted; when the annulus pressure is not enough, a working pump automatically pumps annulus protection liquid to be injected in the annulus, so that the annulus pressure is supplied; and sampling for the annulus protection liquid of the oil sleeve is achieved through the working pump, performance changes of the annulus protection liquid are detected, and the annulus protection liquid in the oil sleeve annulus can be replaced timely. The method has the advantages that the installation and construction technology are simple and convenient, a set of independent, safe and intelligent control system is formed, the pressure in the oil sleeve annulus can be stabilized effectively, the independent, safe and intelligent control system can be used for the sampling and replacing for the annulus protection liquid of the oil sleeve, various safety technological operation and maintenance of an wellbore of an oil gas well is carried out conveniently, and production and other operation of the oil gas well are not influenced.

The invention provides a rotary shaft crusher capable of intelligent overload control and an overload control method of the rotary shaft crusher. The rotary shaft crusher comprises a PLC (Programmable Logic Controller), a pressure sensor, a hydraulic system, at least two rotary shafts, an intermediate relay and an alternating-current contact, wherein the PLC is provided with a pressure segmentation control module which comprises a pressure detection unit, a main circulating type control section unit, a pressure overload information storage unit and a rotary shaft type control unit. According to the rotary shaft crusher, the defects of the existing similar rotary shaft crushing systems such as a garbage crusher system are improved; an intelligent overload control program is arranged inside the existing rotary shaft crusher, the system pressure is periodically detected in a circulating manner, once materials are excessive or are blocked to be delayed to be crushed, the directions of the rotary shafts can be changed intelligently, so that the mechanical breakage of the system caused by pressure overload due to material blockage can be avoided.

The invention relates to a lumbar vertebra rehabilitation training device, and aims to effectively solve the problems that reasonable transition lacks between passive rehabilitation and active rehabilitation of a patient suffering from lumbar vertebra diseases, and the curative effect of a massaging device is poor. The technical scheme for solving the problems lies in that the lumbar vertebra rehabilitation training device comprises a bed body, wherein a through hole is formed in the middle part of a bed board; a supporting unit which can move up and down is mounted on the lower surface of thebed board, and comprises a housing; a vertical blind hole is formed in the upper end of the housing; a supporting column which is jointed to the inner wall of the blind hole and can move up and downis mounted in the blind hole; the blind hole below the supporting column is full of water; a cavity located at the upper part of the housing is formed in the housing; a pressure overload device is arranged between the bottom of the blind hole and the cavity; a fluid returning channel communicates with the cavity and the bottom of the blind hole; and a tapered plug of which the small end faces thefluid returning channel is mounted at the lower end opening of the fluid returning channel. According to the lumbar vertebra rehabilitation training device disclosed by the invention, the transition of the exercising intensity of the patient along with the rehabilitation cycle can be well performed, and the rehabilitation of the patient is facilitated.

A measurement pickup is provided offering a high measure of safety and having a measurement pickup housing, a sensor element arranged in the measurement pickup, at least one connection element closing the measurement pickup housing, and an excess-pressure protection device, especially a burst disk or a pressure relief valve, integrated in the connection element, which serves to effect a pressure equalization with an environment of the measurement pickup in the case of a pressure overload in the measurement pickup.

The invention relates to a slow release dosing pump which is buried in a human body and pressed through the deformation of an elastic membrane, comprising a pump body, a puncture membrane, a sieving plate, an elastic membrane, an internal duct, a diverting valve and an overload valve. The invention is characterized in that: the pump body and the puncture membrane form an inner cavity by a fixing sealing ring through embedded pressing or adhering, the inner cavity is divided into two parts, namely an upper chamber and a lower chamber, by the sieving plate; the lower chamber is provided with the elastic membrane which is coated on the sieving plate completely and can swell in the lower chamber, and after being injected into the upper chamber, the liquid medicine flows into the lower chamber through the sieving pores of the sieving plate and causes the elastic membrane to deform and swell until fully filling the lower chamber; in addition, the upper chamber is communicated with the exterior of the pump by the internal duct which is provided with the diverting valve and the overload valve, the flow speed of the liquid medicine in the upper chamber and the lower chamber to the exterior of the pump can be controlled by using the resiliency produced by the deformation of the elastic membrane and adjusting the diverting valve and the overload valve. The slow release dosing pump can precisely control the flow speed of the liquid medicine, has the function of pressure overload washing and the characteristics of simple structure, durable using and convenient maintenance. The medicine can be repeatedly filled through the skin, being convenient for patients to use.

The invention discloses a remote-controllable medical oxygen generation system. The remote-controllable medical oxygen generation system comprises an air compressor, a cool dryer, an air tank, an oxygen generator, a detection tank, an oxygen tank and a central control system, wherein the air compressor, the cool dryer, the air tank, the oxygen generator, the detection tank and the oxygen tank areall sequentially connected through pipelines, filters are separately arranged on the pipeline between the air compressor and the cool dryer and the pipeline between the cool dryer and the air tank, anair detecting device is mounted at an air inlet of the oxygen generator, pressure sensors and air pressure overload protecting valves are separately mounted in the air compressor, the air tank, the detection tank and the oxygen tank, an oxygen concentration analyzer is further arranged in the detection tank, an air flowmeter and an oxygen flowmeter are separately arranged at an air inlet of the air tank and a gas outlet of the oxygen tank, the air detecting device, the pressure sensors, the oxygen concentration analyzer, the air flowmeter and the oxygen flowmeter are connected with the central control system on the basis of a communication network, and the central control system is connected with an upper computer.

The invention relates to a gradual lumbar vertebra rehabilitation training device, and aims to effectively solve the problems that reasonable transition lacks between passive rehabilitation and activerehabilitation of a patient suffering from lumbar vertebra diseases, and the curative effect of a massaging device is poor. The technical scheme for solving the problems lies in that the gradual lumbar vertebra rehabilitation training device comprises a bed body, wherein a through hole is formed in the middle part of a bed board; a supporting unit which can move up and down is mounted on the lower surface of the bed board, and comprises a housing; a vertical blind hole is formed in the upper end of the housing; a supporting column which is jointed to the inner wall of the blind hole and can move up and down is mounted in the blind hole; the blind hole below the supporting column is full of water; a cavity located at the upper part of the housing is formed in the housing; a liquid inlet channel and a liquid returning channel are formed between the bottom of the blind hole and the cavity; and a pressure overload device is arranged on the liquid inlet channel. According to the gradual lumbar vertebra rehabilitation training device disclosed by the invention, the transition of the exercising intensity of the patient along with the rehabilitation cycle can be well performed, and the rehabilitation of the patient is facilitated.

The invention relates to a clinical use of lipoic acid in treatment on pressure-loaded myocardial injury. Lipoic acid is applied to a patient suffering from pressure-loaded myocardial injury based onthe standard treatment so that the activity of the myocardial mitochondrial aldehyde dehydrogenase 2 (ALDH2) is improved, the myocardial mitochondrial energy metabolism is improved, the oxidative stress is inhibited, the cardioprotective effect is produced and the occurrence and development of myocardial injury is delayed. Lipoic acid can improve myocardial mitochondrial energy metabolism throughrecovering the activity of ALDH2 in the myocardial mitochondria, inhibit oxidative stress, prevent the myocardial injury after pressure overload and improve the quality of life of patients. The use provides a novel use for lipoic acid so that the lipoic acid can be well used. The use provides a novel drug research direction for pressure-loaded myocardial injury diseases and has a good applicationprospect.

The invention discloses an integrated force sensor. The integrated force sensor is characterized by including a base body, a flexible through cavity arranged on the base body, and flexible skin covering the flexible through cavity; the base body is provided with a bulge, the flexible through cavity is divided into two sections under the action of the bulge, one end of the flexible through cavity is connected with a pressure sensor for measuring the internal pressure of the flexible through cavity, and the other end of the flexible through cavity is communicated with outside air. According to the integrated force sensor, to-be-detected force changes air pressure by changing the shape of an object, so that the size of the to-be-detected force is detected through detection of the air pressure; moreover, overloaded pressure can be released through a pressure releasing mechanism so that the safety of the film of the pressure sensor cannot be affected, and even the pressure which is overloaded more than static pressure by 100 times cannot cause permanent damage to the film.

The invention discloses a mechanical pressure overload protector, which comprises a pressure-tapping pipe and a valve, and the pressure-tapping pipe and the valve are sequentially arranged on a pipeline according to the direction of gas flow in the pipeline to be protected; the other end of the pressure-tapping pipe is connected with a guide pipe; the other end of the guide pipe is fixedly connected with a housing; the inner diameter of the third section of the housing is greater than the outer diameter of the guide pipe; an isolating plate and a pressure-transferring structure are sequentially arranged in the third section of the housing according to a direction away from the guide pipe; the pressure-transferring structure is a two-section stepped column, and a holder is sleeved on the pressure-transferring structure. When the pressure in the pipeline exceeds a set value, the mechanical pressure overload protector can quickly close the valve by means of the displacement of an actuating rod converted from the motion of the pressure-transferring structure, a pressure-operated rod and a gear structure; when pressure is recovered, the valve can be quickly opened, and thereby the pressure overload protection for the pipeline can be effectively implemented; meanwhile, the set pressure can be regulated by adjusting a pressure regulation nut; and the mechanical pressure overload protector has the advantages of simple principle and simple and reliable structure, and is easy to put into practice.

The invention discloses a method for deicing a DC line which runs under the double-pole semi-pressure overload in the established DC power transmission system. At present, the DC voltage class is plus or minus 500 kV in the established DC power transmission system in China. When the external insulation level of the line is reduced due to the ice-coated DC line, flashover and other failures occur if the line still runs at a normal voltage for the time being, and finally result in abnormal running of the DC system. Through the appropriate change of the wiring manner inside the valve hall of the established DC power transmission system, and the adoption of DC running voltage of plus or minus 250kV obtained by reducing half of the original DC running voltage, and the possibility of the insulation flashover in the DC system is greatly reduced and the line can run under the overload, so that the method is realized. The method has the advantages that no main device is added, the insulation level of the prior device is not required to improve, and the wiring manner inside the valve hall is only required to appropriately change, therefore the method has higher use value.

The invention discloses a protection device, and aims to provide an air pressure overload protection device, which is simple in structure, realizes real-time monitoring and is capable of running fully automatically. The air pressure overload protection device is arranged on a main air pipe (9) and comprises a box (1), an electromagnetic valve (2), an adjustable pressure switch (3), a time relay (4), an intermediate relay (5) and a pressure gauge (6), wherein the time relay (4) is electrically connected with the electromagnetic valve (2), the adjustable pressure switch (3) is arranged on the main air pipe (9) and electrically connected with the time relay (4), the pressure gauge (6) is communicated with the adjustable pressure switch (3), the intermediate relay (5) is electrically connected with the time relay (4), and both the adjustable pressure switch (3) and the time relay (4) are communicated with a peripheral circuit. The air pressure overload protection device can be widely applied to the field of air compressor control.

The invention belongs to the technical field of biological pharmacy, and discloses a medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application. The application comprises the following steps of: establishing a pressure overload rat myocardial hypertrophy and ventricular remodeling animal model by adopting abdominal aorta constriction; constricting the abdominal aorta for 28d, and sequentially detecting the change of a hemodynamic index and the diameter of a myocardial cell; and transecting the left ventricular myocardial tissue of a rat, observing the form of the myocardial cell under an optical microscope after conventional HE staining, and observing the change effect of leonurine on the pathological form of the left ventricular myocardial tissue of the rat. The invention proves that high and low dosage groups of leonurine have a certain improvement effect on cardiac diastolic and systolic dysfunction of a myocardial hypertrophy rat induced after abdominal aorta constriction; the high and low dosage groups of leonurine can reduce the left ventricular hypertrophy index of the rat after AAC operation; and the high and low dosage groups of leonurine and a positive group can inhibit myocardial cell hypertrophy of the rat after AAC operation and inhibit ventricular remodeling.

The invention belongs to the field of biomedicine and discloses drug use of 5-bromo-2-(alpha-hydroxypentyl) sodium benzoate (BZP) in treatment of cardiac hypertrophy and heart failure. Mice with myocardial hypertrophy induced by pressure overload after aortic coarctation were used in this study. The effects of pressure overload on myocardial hypertrophy, It was found that oral administration of BZP could decrease the cardiac weight-to-body weight ratio after aortic coarctation in mice, Heart weight tibia length ratio, reduce the cross-sectional area of hypertrophic cardiomyocytes, reduce the level of myocardial fibrosis, reduce the expression of hypertrophy-related genes, improve cardiac function injury induced by pressure load, reduce myocardial hypertrophy, reduce the occurrence of myocardial remodeling, and postpone the process of heart failure. It will hopefully be developed into a new class of drugs for cardiovascular treatment.

The invention relates to determination of an angiotensin II-1 type receptor perception site. Different AT1R mutants are constructed through an amino acid residue point mutation method to find different pathologic perception sites of AT1R, and the results shows that an Lys199 site of the AT1R is an Ang II perception site, Leu 212 and Cys 289 sites are mechanical stress perception sites, and a Gln 257 site is a common perception site of the Ang II and overloading pressure. By means of determination of the angiotensin II-1 type receptor perception site, design of the new generation of ARB medicines aiming at mechanical stress or the Ang II activated amino acid residue site can be guided, clinical medication can be guided, selective targeting of diseases, such as hypertensively myocardial hypertrophy, mediated by the AT1R is improved, adaptation diseases of the ARB type medicines are evaluated and compared, and the fundamental research of occurrence and development mechanisms of relevant diseases is guided.

The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.

The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to myocardial infarction and pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.

The invention relates to an application of FTO (Fat mass and obesity associated) protein as a target in treatment of pressure-loaded myocardial injury. It is proved that after a heart is stimulated bypressure overload, FTO down-regulation is an important cause of myocardial damage; a mouse with overexpression FTO pressure-loaded myocardial injury is obviously increased in myocardial sugar uptakeand obviously improved in cardiac function compared with those of a mouse in a model group, so that the overexpression FTO can treatment myocardial injury after pressure overload, and FTO is a drug target for treatment of pressure-loaded myocardial injury. The invention further provides an FTO overexpression vector with a remarkable curative effect. The application has the advantages that the application of the FTO as the treatment target for improving the pressure-loaded myocardial injury is developed, and a new drug research direction is provided for the pressure-loaded myocardial injury disease; and the invention provides a myocardial injury drug after pressure overload with FTO as the target, and the drug has a clinical application prospect.

The invention relates to a super-plastic expansion anti-oxidation program control precise loading experiment device and an experiment method. The device mainly consists of an anti-oxidation air source, two paths of loading air paths, a preheating and heating device, an edge pressing mold required by expansion and the like, wherein the loading air paths have the pressure test and control functions and respectively consist of precise pressure reducing valves, step motors, increment type rotating encoders, pressure sensors, high / low-pressure pressure switches, electromagnetic reversing valves and corresponding driving and control systems, the precise pressure reducing valves are driven by the step motors, and the encoders detect the motor rotating angle. The control systems control to complete various loading modes including the constant pressure, variable pressure, pressure saltus and the like. The high / low-pressure pressure switches are combined with a digital logic circuit for forming a safety protection device, and the damage and the pressure overload caused on the precise pressure reducing valves can be prevented. The loading device can adopt closed loop serial PID (proportion integration differentiation) control for the pressure regulation, the loading process is safe and reliable, and higher control precision and better response characteristics can be realized in the pressure regulating process.

The invention discloses color Doppler ultrasound abortion equipment with the negative pressure display and control functions and a control device and method. The equipment comprises a negative pressure generator, a negative pressure meter, a negative pressure pipe, a work probe, a foot-stepping negative pressure controller, a single chip microcomputer, a negative pressure collecting module, a negative pressure overload valve, a negative pressure overload pipe, a control host, a display, an operation keyboard and a color Doppler ultrasound assembly. The negative pressure collecting module is installed on the negative pressure pipe and connected with the single chip microcomputer through a data line; the negative pressure overload pipe is connected with the negative pressure pipe; the negative pressure overload valve is installed on the negative pressure overload pipe and connected with the single chip microcomputer through a control line; the single chip microcomputer is connected with the control host. According to the color Doppler ultrasound abortion equipment, a real-time negative pressure value of the negative pressure pipe is collected and compared with a negative pressure overload value, the negative pressure in the negative pressure pipe is released by opening the negative pressure overload valve if the pressure in the negative pressure pipe is too small, the purpose of controlling the pressure of the negative pressure pipe is achieved, and therefore unnecessary extra hurt, generated due to the over large negative pressure, to a human body can be avoided.

The invention discloses a poultry pen cleaning device for the animal husbandry. The poultry pen cleaning device for the animal husbandry comprises a main hollow shell, wherein a current controller isinstalled on the side surface of the main hollow shell, and a supporting rod is installed at the center of the bottom of the main hollow shell. One motor can be used for achieving not only a liquid injection function on ground cleaning liquid but also a liquid high-pressure jetting function, so that several purposes are realized through the one device, and the utilization rate of the motor is increased. High-pressure water flow is jet to the ground, so that the ground of a poultry pen is cleaned efficiently and rapidly. In addition, the device is provided with an air-liquid raw material turbotype injection mechanism which can be used for achieving not only a liquid injection function but also an air injection function. Moreover, the device is provided with a pressure overloading preventing control mechanism which can not only play a role in protecting the motor but also prevent the phenomenon of overlarge air pressure. Furthermore, the device is provided with an air-liquid raw material injection control mechanism, so that either injected materials are liquid or air can be controlled according to practical situations, and the practicality is high.

The invention discloses application of ganoderma lucidum spore powder in preparing medicine for preventing and treating compensatory cardiac hypertrophic heart disease. The ganoderma lucidum spore powder is preferably the ganoderma lucidum spore powder obtained by an ultra-low temperature freeze-thawing breaking method. In the invention, a mouse model of cardiac hypertrophy is induced by pressureoverload, the morphological structure and function of the heart of the mouse are evaluated by the left ventricular wall thickness, the inner diameter, the ejection fraction, and the histopathology andother indexes, and results indicate that the ganoderma lucidum spore powder (150 mg / (kg.BW)) can correct the morphological structure and function of the heart of the mouse with myocardial hypertrophyinduced by pressure overload. At the same time, the gene sequencing technology and bioinformatics analysis are applied, and it is found that ganoderma lucidum spore powder can protect the heart fromheart injury caused by pressure overload by regulating the changes of mRNA expression profile and by the multi-target and multi-channel integration regulation, wherein endocytosis, insulin signaling pathway and focal adhesion signaling pathway may be important regulatory mechanisms thereof.

A pressure overload protector for a sensor includes a pressure-filled channel system fillable with fluid or gas, a first overload stop seated in an open position, a first diaphragm at the unseated end of the first overload stop, a second overload stop seated in an open position, a second diaphragm at the unseated end of the second overload stop, a sensor connected to a fluid channel, and a third and fourth overload stop connected by channels to the fluid channel of the sensor and terminating at a fluid exit. The overload protector provides bidirectional over and under pressure protection to the sensor.

The invention relates to a method for constructing a cardiac pressure overload / unloading mouse model. The invention proposes a new stable overload / unloading animal model construction method by carrying out animal experimental research. The conventional practice of constructing a pressure overload model is to directly knot the aortic arch when it is narrowed, which has poor stability. The improvement of the present invention is characterized in that two small PE10 catheters are used, and the two ends of a 7-0 surgical line firstly pass through a PE10 catheter simultaneously, and then one of theends separately passes through another PE10 catheter, and finally the two ends are subjected to knotting. The improved method solves the problem of difficulty finding the knotting position and difficultly unraveling when the aortic arch is reinstated, significantly reduces the phenomenon of large bleeding during the operation, improves the operability and reliability of the experiment, reduces the difficulty of model construction, and improves the stability and uniformity of the model. The method provides animal models that are more stable and more in line with clinical features for the studyof related diseases.

The invention discloses polynucleotide having the sequence as shown in SEQ ID No. 1. The polynucleotide or a vector provided by the invention carries NCoR1 or an RIDs core fragment in the NCoR1, and can significantly alleviate the cardiovascular diseases, such as cardiac hypertrophy and cardiac dysfunction, caused by pressure overload after cell transduction; it is verified that the expression ofthe NCoR1 in myocardial tissues of patients and mice suffering from the cardiac hypertrophy is increased and the NCoR1 can be used as a biomarker for diagnosis of the cardiac hypertrophy.

The invention discloses a multifunctional high-voltage equipment safety performance detection device. It includes gas power system, water injection exhaust system, pressure lifting system, measurement control system and safety protection system. During the high-pressure test, the pressure medium is quickly filled into the high-pressure equipment through the liquid pipeline by the water injection and exhaust system, and the gas in the equipment is discharged. The pressurization, pressure maintenance and pressure relief operations are completed by the pressure lifting system. The power required for the treatment process is provided by the gas power system. The measurement control system monitors and controls the entire testing process and outputs process data. When the pressure is overloaded, the safety protection system ensures safety. The device can test the safety performance of high-voltage equipment, including withstand voltage test, fatigue test, burst test and stress test analysis. It has the advantages of fast boosting, stable pressure, easy operation, safety and reliability.

The invention relates to a pressure overload transfer device which is connected between a first buffer device (15) and a second buffer device (16) and comprises a casing (10). The pressure overload transfer device is characterized in that the device consists of two parts, namely a pressure transfer component and an air inflation component. Meanwhile, the invention further relates to a method for transferring overloaded pressure by the pressure overload transfer device. The device is mainly used in gas buffer devices, such as closed air buffer devices of an air bag type or an air cylinder type and the like, automatic control for impact overload protection and transferring (partial pressure) of a group (two or more) closed gas type buffer devices is achieved, so that complementation, pressure range control, buffering capacity control and volume utilization maximization among the one group (two or more) closed gas buffer devices are achieved; and accordingly, the production cost is reduced, the equipment size is reduced, and utilization ratio and practical performance of the closed gas buffer devices such as the air bag type or the air cylinder type and the like are improved.