Immunoglobulin-like molecules directed against fibronectin-eda

A technology combined with fibronectin, -EDA, used in cardiology and angiogenesis, medical field, can solve problems such as adverse immune system and improper heart healing

Inactive Publication Date: 2017-11-28
ENCARE BIOTECH BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In many patients, the immune system is activated in an unfavorable manner, leading to improper healing of the heart after myocardial infarction

Method used

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  • Immunoglobulin-like molecules directed against fibronectin-eda
  • Immunoglobulin-like molecules directed against fibronectin-eda
  • Immunoglobulin-like molecules directed against fibronectin-eda

Examples

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Embodiment Construction

[0084] Immunoglobulin-like molecules, antibodies and antigen-binding fragments thereof

[0085] In a first aspect, the present invention relates to an isolated Ig-like molecule or an antigen-binding fragment thereof that specifically binds to the amino acid sequence GIXXXF (SEQ ID NO: 1) or the amino acid sequence LFPAP (SEQ ID NO: 28), wherein X can be any amino acid.

[0086] The term "isolated" as used herein refers to a material that is substantially or substantially free from components with which it normally accompanies in nature.

[0087] The term "immunoglobulin" (abbreviated "Ig") as used herein is well known in the art and is equivalent to the term "antibody". The term "Ig-like molecule" as used herein refers to any polypeptide comprising an antigen binding site with at least one complementarity determining region (CDR). The term includes, but is not limited to, polyclonal antibodies, monoclonal antibodies, monospecific antibodies, multispecific antibodies, humani...

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Abstract

The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.

Description

technical field [0001] The invention relates to the field of medicine, and in particular the fields of cardiology and angiogenesis. The invention provides immunoglobulin (Ig)-like molecules, such as antibodies, and antigen-binding fragments thereof that specifically bind the EDA-domain of fibronectin-EDA. These Ig-like molecules are particularly suitable for the treatment, prevention or development of adverse cardiac or vascular remodeling and complications associated with myocardial infarction and amelioration or stimulation of angiogenesis. The invention also relates to the treatment of conditions associated with excessive pressure overload. The present invention also relates to pharmaceutical compositions comprising Ig-like molecules, such as antibodies or antigen-binding fragments thereof, and the use of Ig-like molecules, such as antibodies or antigen-binding fragments thereof, for the treatment, prevention of myocardial infarction-related complications and adverse cardi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/18A61K39/395A61P7/06
CPCC07K16/18A61K2039/505A61K2039/545A61K2039/54C07K2317/34A61P9/10A61P7/06A61P9/00A61K39/39541C07K16/24
Inventor F·阿斯兰
Owner ENCARE BIOTECH BV
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