Medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application

A technique for ventricular remodeling and myocardial hypertrophy, which is applied in the drug and application of ventricular remodeling, in the field of anti-pressure overload myocardial hypertrophy, and can solve problems such as no research on leonurine.

Inactive Publication Date: 2021-05-11
贵州中医药大学
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Problems solved by technology

[0003] To sum up, the problem existing in the prior art is that the application of Leonurine in anti-stress overload myocardial hypertrophy and ventricular remodeling is still a research.

Method used

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  • Medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application
  • Medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application
  • Medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application

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Experimental program
Comparison scheme
Effect test

Embodiment

[0028] 1. Effect of Leonurine on the hemodynamic indexes of pressure-induced ventricular remodeling rats (see Table 1)

[0029] After 28 days of coarctation of the abdominal aorta, the hemodynamic indexes of the rats in each group showed that compared with the sham operation group, the LVSP and LVEDP of the rats in the model group were significantly increased (P<0.01), (+)dp / dtmax and (+)dp / dtmax and ( -) dp / dtmax decreased significantly (P<0.01), which indicated that after abdominal aortic constriction, the diastolic and systolic function of the rats was impaired. Compared with the model group, the high and low dose groups of leonurine and the positive drug losartan group could all reduce LVSP and LVEDP, and increase (+)dp / dtmax and (-)dp / dtmax (P<0.05), the above results Tips: Leonurine high and low dose groups and losartan group can improve cardiac diastolic and systolic dysfunction in rats with myocardial hypertrophy induced by abdominal aortic constriction.

[0030] Tabl...

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Abstract

The invention belongs to the technical field of biological pharmacy, and discloses a medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application. The application comprises the following steps of: establishing a pressure overload rat myocardial hypertrophy and ventricular remodeling animal model by adopting abdominal aorta constriction; constricting the abdominal aorta for 28d, and sequentially detecting the change of a hemodynamic index and the diameter of a myocardial cell; and transecting the left ventricular myocardial tissue of a rat, observing the form of the myocardial cell under an optical microscope after conventional HE staining, and observing the change effect of leonurine on the pathological form of the left ventricular myocardial tissue of the rat. The invention proves that high and low dosage groups of leonurine have a certain improvement effect on cardiac diastolic and systolic dysfunction of a myocardial hypertrophy rat induced after abdominal aorta constriction; the high and low dosage groups of leonurine can reduce the left ventricular hypertrophy index of the rat after AAC operation; and the high and low dosage groups of leonurine and a positive group can inhibit myocardial cell hypertrophy of the rat after AAC operation and inhibit ventricular remodeling.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a drug for resisting pressure overload myocardial hypertrophy and ventricular remodeling and its application. Background technique [0002] At present, the closest prior art: Cardiac hypertrophy is a common pathophysiological change in various cardiovascular diseases such as hypertension, coronary heart disease, heart valve disease, congenital heart disease, and cardiomyopathy, and is a key factor in cardiac function. The evolution from the compensatory period to the decompensated period is a key stage in the development of cardiac structure from reversible change to irreversible change, and is an important pathophysiological basis of heart failure. Pressure overload induces myocardial hypertrophy and ventricular remodeling is one of the main reasons. Leonurine is one of the extracts of the traditional Chinese medicine Motherwort, which has the effect of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P9/00A61P9/04A61K49/00
CPCA61K31/216A61P9/00A61P9/04A61K49/0008
Inventor 钱海兵袁青青刘晓龙李媛李姝臻
Owner 贵州中医药大学
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