30 results about "Peri-implantitis" patented technology

The present invention for the first time discloses a method and a kit of parts for treating a periodontal disease, such as periimplantitis, gingivitis, periodontitis and / or periimplant mucositis, caused by microorganisms that colonize a tooth and / or implant surface at, above and / or below the gingival margin, and which reside in a biofilm either subgingival and / or supragingival, characterized by employing a surgical process leading to substantively removing, destroying, killing and / or disrupting and / or inhibiting growth and / or regrowth of a pathogenic biofilm at a site of a microbial infection in a patient suffering from a periodontal disease. Said method comprises, and said kit of parts comprises the means for; cleaning disinfecting and / or debriding the site of microbial infection mechanically and sequentially using first at least one cleaning and / or disinfecting agent with an immediate bactericidal effect, such as a NaClO solution, and thereafter at least one cleaning and / or disinfecting agent with a sustainable bactericidal effect, such as a CHX solution.

The present invention belongs to the fields of dental implants and surface treatment, and relates to a dental implant, an implant tooth and a preparation method of the dental implant. The dental implant is divided into two parts of a neck region and a body region along an axial direction, and the neck region has anti-microorganism properties and the body region has osteogenic properties by controlling a surface microstructure. The provided dental implant has super hydrophilicity / hydrophobicity. Aiming at the neck region of the dental implant, the specific structure based on the structure enables the dental implant to have super hydrophobicity and anti-microorganism functions, solves a major clinical demand that adhesion and proliferation of oral bacteria in junction areas between soft andhard tissues of the dental department lead to peri-implant inflammation to cause loss of the implant, and forms an effective biological seal; and aiming at the implant body, a multi-level micron morphology based on the surface structure enables the dental implant to have super hydrophilicity, and is also more conducive to adhesion and proliferation of osteoblasts.

The invention provides a bionic micro / nano antibacterial structure, a manufacturing method therefor and application of the bionic micro / nano antibacterial structure. The bionic micro / nano antibacterial structure is applied to an oral cavity implant and comprises an implant base station and micro / nano burs which are arranged on the implant base station and are tightly incorporated with the implantbase station. According to the bionic micro / nano antibacterial structure, the micro / nano bur structure with an antibacterial function is applied to the surface of the implant base station, so that theimplant base station can have very good antibacterial performance, bacteria surrounding an implant can be inhibited durably, and periarthritis of the implant can be eliminated or decelerated; and thebionic micro / nano antibacterial structure is harmless to human bodies.

The present invention relates to a design and manufacturing method of a surface structure of a parodontium-simulated dental implant. The design and manufacturing method comprises the following steps:1) a dental implant is divided into 2 layers and printing files are generated by using a 3D printing software; 2) an inner layer is a solid structure and an outer layer is a gradient hollow structurewith gradually increased porosity from inside to outside; 3) the porosity of an innermost layer of the hollow structure is 0 and the porosity of an outermost layer is 50-80%; 4) pores and interstitialtrabecula are trabecula-like structures; 5) printing and forming are conducted by using a laser cladding 3D printer; 6) the used material can be pure titanium, titanium alloy, zirconia or titanium-zirconium-based amorphous metal glass; and 8) the dental implant can be used as a dental implant product after being sterilized. The method can effectively improve osteogenesis performance of a surfaceof the dental implant, simulates a mechanical buffering effect of parodontium to a certain extent, reduces local stress concentration in a chewing functional state, obviously reduces occurrence and progress of inflammation around the dental implant through the complex bone interface structure of the dental implant, and improves long-term success rate of dental implant restoration.

The invention relates to the technical field of dental implantation, in particular to a pterygoid plate-penetrating implant and an oral implant. The pterygoid plate-penetrating implant comprises an implant head part and an implant neck part which are connected in sequence, the implant head part is a conical body, the outer diameter of the implant head part is gradually increased from the near endto the far end, the implant head part comprises a tip part and a mounting part connected to the tip part, the near end of the tip part is a tip, the mounting part is connected to the implant neck part, a self-tapping threaded section is arranged on the periphery of the tip part, a double-line threaded section is arranged on the periphery of the mounting part, and a self-tapping groove is formed inthe implant head part. The implant head part is conical, a plurality of threaded sections are arranged on the implant head part, and the implant head part is of a double-thread structure and has self-tapping performance; and the tip of the implant head part has certain cutting capacity. The implant neck part is beneficial to osseointegration and convenient to cleaning after bone resorption, and prevents inflammation around the implant.

The invention discloses an implant for improving the sealing performance of soft tissue around the implant. The implant comprises a body part and a base foundation or a neck part, wherein the base foundation is connected with the body part through a screw; the neck part is integrally connected with the body part; the upper part of the body part matches with the bottom of the base foundation to form a shoulder foundation of 0.2-0.7mm wide; a first micro pore zone of 3-5mm wide is arranged on the implant; first micro pores which are uniformly distributed are formed in the first micro pore zone;the size of the first micro pores is 1-3 micrometers; the surface of an area above the first micro pore zone is a smooth surface; and the first micro pore zone is positioned on the surface of the basefoundation or the neck part above the top of the body part. The implant emphasizes on creativeness of the sealing performance of a gum threading part of the implant, the adhesiveness of soft tissue to the implant is improved, mucosal inflammation around the implant and peri-implantitis can be reduced, and the long-term success rate of implanting can be increased.

The present invention belongs to the fields of dental implants and surface treatment, and relates to a dental implant, an implant tooth and a preparation method of the dental implant. The dental implant is divided into two parts of a neck region and a body region along an axial direction, and the neck region has anti-microorganism properties and the body region has osteogenic properties by controlling a surface microstructure. The provided dental implant has super hydrophilicity / hydrophobicity. Aiming at the neck region of the dental implant, the specific structure based on the structure enables the dental implant to have super hydrophobicity and anti-microorganism functions, solves a major clinical demand that adhesion and proliferation of oral bacteria in junction areas between soft andhard tissues of the dental department lead to peri-implant inflammation to cause loss of the implant, and forms an effective biological seal; and aiming at the implant body, a multi-level micron morphology based on the surface structure enables the dental implant to have super hydrophilicity, and is also more conducive to adhesion and proliferation of osteoblasts.

The present invention relates to the field of medical devices and particularly to an oral implant for preventing peri-implantitis. The provided oral implant for preventing peri-implantitis comprises an implant body and a porous surface layer distributed on the surface of the implant body, and the porous surface layer comprises Zn and Sr. The provided implant is simple in body structure and low inmanufacture cost. The surface of the implant body comprises the porous surface layer, besides, the porous surface layer is doped with Sr and Zn, the two elements can play a synergistic effect, so thatthe implant body has better osteogenic induction performance and microorganism inhibition functions. The implant body can be further used to prepare the oral implant. The oral implant shows excellenteffects in preventing and relieving peri-implantitis and thus has a good industrialization prospect.

The invention provides a group of gingival crevicular fluid markers for predicting oral peri-implantitis, an application thereof, a kit and a preparation method of the kit, which belong to the technical field of biomedicine. The markers described in the present invention include one or more of IL-1α, IL-1β, IL-21, HGF, VEGF-A, GRO-α and IL-8. The prediction of oral peri-implantitis by using the biomarker provided by the invention or the kit prepared by the biomarker has the advantages of rapid detection, accuracy, low cost and the like, and has broad application prospects.

The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and pro longed release of at least one pharmaceutically active agent at the bone loss site.

The invention relates to the technical field of biological materials, in particular to an implant material that can be used for osteoporosis patients and a preparation method and application thereof. The implant material includes TiO 2 coating, the TiO 2 The coating is doped with biological trace element components, the TiO 2 The mass percentage content of the coating is 74-78%, and the mass percentage content of the biological trace element component is 22-28%; the biological trace element component is selected from strontium and / or zinc. The implant material of the present application is a material that can promote osseointegration and bone regeneration around the implant material, optimizes the concentration of zinc and / or strontium on the surface of the implant, and has the advantages of promoting osteoporosis osteogenesis and implant osseointegration at the same time. Better antibacterial effect to prevent possible osseointegration and peri-implantitis resulting in implant failure after implant material is placed in osteoporotic patients.

The oral administration of bioavailable silicic acid, such as choline-stabilized silicic acid during a period of at least 3 months daily leads to the prevention, inhibition and or treatment of periodontitis and peri-implantatis. The treatment is particularly suitable in combination with appropriate cleaning of the teeth and disinfecting the mouth, by one or more antiseptic and / or antimicrobial agent(s), as carried out at least once and suitably regularly, such as once per year, twice per year, four times per year or even every second month or every month. The treatment may be further enhanced by simultaneous administration of vitamins, trace elements, as well as by administration of a probioticum. Such additional agents may be applied separately, but are preferably incorporated in the formulation of bioavailable silicic acid.

The invention discloses a modularized layered dental implant. The modularized layered dental implant comprises a module layer and a bottom layer, wherein the module layer comprises a plurality of module units, all the module units are stacked in the vertical direction, every two vertically adjacent module units are detachably connected, the outer side wall of at least one module unit is provided with a plurality of accommodating holes, a first external thread is formed in the outer side wall of at least one module unit; and the bottom layer is detachably connected to the bottom of the module layer, and a second external thread is arranged on the outer side wall of the bottom layer. According to the modularized layered dental implant disclosed by the invention, the module units on a top layer are removed through a repairing tool and are cleaned and replaced, so that the problem of inflammation around the implant is effectively solved. According to the condition of alveolar bone deficiency of a patient, the module units on the top layer with the proper height and diameter can be selected for replacement, and personalized repair is achieved. The dental implant can be applied to the field of dental implants.

The present invention relates to a complex comprising at least one lactoferrin and at least one silica having a specific surface area comprised between 100 m2 / g and 1000 m2 / g (BET area, measured according to standard ISO 9277-2010). The complex is obtainable by adding the lactoferrin to the silica in the form of a sol-gel with an aqueous solvent, and subsequent drying of the sol-gel. The complex is particularly suitable for use in oral care products, in particular toothpastes, mouthwashes, gels, chewing gum, tablets for use in oral care, gingival dyes, and the like. The complex features a highlevel of stability and bio-availability, such that it has an effective, long-lasting antibacterial and antioxidant action within the oral cavity. The complex is particularly suitable for the prevention or treatment of diseases of dental apparatus, in particular for the prevention or treatment of periodontitis or peri- implantitis, preferably in patients suffering from diabetes.

The invention discloses an implant abutment gum-penetrating structure having a visible light functionalization function and a production method thereof. The structure comprises an implant abutment, amaterial of the implant abutment is titanium, the implant abutment is composed of an abutment upper part, the abutment gum-penetrating structure, and an abutment lower part, the abutment gum-penetrating structure is positioned between the abutment upper part and the abutment lower part, the surface of the abutment gum-penetrating structure is the nano structure having a nano-gold particles-loadedTiO2 nanotube, and the structure has the characteristic of generating light functionalization under irradiation of visible light. The abutment gum-penetrating structure is used for preparing the nano-gold particles-loaded TiO2 nanotube through an anodization method and a self assembly method. The abutment gum-penetrating structure is capable of generating light functionalization under irradiationof the visible light, the generated superoxide radical and hydroxyl radical to kill peri-implantitis pathogenic bacteria, destroys a plaque biofilm, purifies the surface of the abutment gum-penetrating structure, and is used for preventing and treating peri-implantitis.

The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the bone loss site.

An ultrasonic tip, attachable to an ultrasonic handheld instrument for vibrational energy, and method for treating peri-implantitis by removing a thin layer of the surface of the contaminated metal implant base that is exposed from the loss of osseo-integration due to bacteriological biofilms. The ultrasonic tip includes a narrow wire shaft body having at its distal end a concave abrasive diamond-coated tapered grinder plate with a front grinding surface, tapered in thickness from top to bottom, that can be manually pressed against an exposed implant base vertical cylindrical diseased surface while the grinder plate is vibrated ultrasonically to remove a thin layer of the titanium alloy metal implant base. The ultrasonic tip narrow wire shaft body has three bends to avoid the crown when manually positioning the grinding surface of the grinder plate to ensure manipulation the grinding surface by the periodontist. A detoxicant liquid is introduced during cleaning to enhance removal of diseased material by vibration of the liquid to penetrate microstructural surface areas of the implant base.

The invention discloses a peri-implantitis treatment device capable of promoting synostosis. The peri-implantitis treatment device comprises a shell, and is characterized in that a liquid medicine supply tube, an ultrasonic generation device, a transduction transmission device, a negative pressure recovery device for recovering waste liquid, a control device and a power supply are arranged in the shell; the power supply, the ultrasonic generation device, the transduction transmission device and the negative pressure recovery device are all connected with the control device; a treatment tip used for being in threaded connection with an implant is arranged at the end of the shell; the treatment tip comprises a liquid medicine tube communicated with the liquid medicine supply tube and a backflow tube communicated with the negative pressure backflow device; the liquid medicine tube is connected with the transduction transmission device; the backflow tube is arranged outside the liquid medicine tube in a sleeving mode; the liquid medicine tube is provided with a plurality of working tips used for being inserted into a gap between an implant and gingiva, and the working tips are provided with liquid medicine holes used for discharging liquid medicine; and a plurality of waste liquid backflow holes are formed in the periphery of the backflow tube. According to the peri-implantitis treatment device, ultrasonic waves are utilized to carry out oscillation cleaning on the peripheral lacuna of the implant, and mechanical micro-stimulation is carried out on the implant, so that synostosis of the implant and an alveolar bone is promoted.

The invention provides a mortise and tenon joint-type repair design method applied to dental crown implantation in a feature-beautifying area. The method comprises the following steps: fixing an implant in an alveolar bone; after the implant and the alveolar bone are combined into a whole, arranging a porcelain abutment at an upper end of the implant; and taking a porcelain veneer, placing the porcelain veneer at an upper end of the porcelain abutment in a sliding manner along a surface of the porcelain abutment, and fixedly connecting the ceramic veneer with the porcelain abutment in a mortise and tenon joint manner. A full dental crown is changed into an improved porcelain veneer, the personalized porcelain abutment matched with the porcelain veneer is designed, the porcelain veneer and the porcelain abutment are fixedly connected in the mortise and tenon joint manner, such that an adhesive is not needed, a problem of inflammation around the implant caused by the residual adhesive is avoided, a success rate of implantation is increased, the porcelain veneer is arranged and a problem of aesthetic defects of a dental crown lip side opening caused by screw retention is effectively solved.

The invention belongs to the technical field of biology, and specifically discloses an antibacterial peptide PLC13 and application thereof to inhibition of peri-implantitis bacteria. The sequence of the antibacterial peptide PLC13 is shown as SEQ ID NO: 1; one end of a peptide chain of the antibacterial peptide is connected with acetate, and the other end of the peptide chain of the antibacterial peptide is connected with an amino group. The antibacterial peptide PLC13 is discovered to have obvious antibacterial activity to the peri-implantitis bacteria, is safe and nontoxic to human bodies, meanwhile has the characteristics of short peptide chain, easiness in synthesis, low cost and the like, and can be effectively applied to inhibiting the infection of oral cavity by the peri-implantitis bacteria, particularly the infection of fusobacterium nucleatum and staphylococcus aureus.

The invention discloses an implant with biological activity and conditional antibiosis, and belongs to the technical field of dentistry, the implant comprises a support body, threads are arranged on the outer side of the support body, the support body is arranged to be of a porous structure, the porous structure provides a support for cell and new bone ingrowth and has osteoconductivity, silver nanoparticles are placed in pores of the porous structure, and the outer side of the porous structure is coated with a bioactive layer. The synergistic strain of the implant and the bone enables the masticatory force to be uniformly dispersed and conducted, the porous structure not only has the advantage of mechanical performance, but also can provide a support for cell and new bone ingrowth, has osteoconductivity, can be used as a biological medicine bin, and is provided with a coating to promote early osteogenesis, the formation of new bones and small blood vessels can be found in the second week to the fourth week after the implant is implanted, and the implant has biological activity. The coating also has a conditional pH antibacterial property, and can effectively prevent the occurrence of peri-implantitis.

A method for designing and manufacturing the surface structure of a periodontal ligament imitation dental implant of the present invention has the following steps: 1) the dental implant is divided into 2 layers, and a print file is generated with 3D printing software; 2) the inner layer is a solid structure , the outer layer is a gradient hollow structure with gradually increasing porosity from the inside to the outside; 3) The porosity of the innermost layer of the hollow structure is 0, and the porosity of the outermost layer is 50-80%; 4) The shape of the trabecular pores and gaps It is a bone-like trabecular structure; 5) It is printed by a laser cladding 3D printer; 6) The material used can be pure titanium, titanium alloy, zirconia or titanium-zirconium-based amorphous metal glass; 8) It can be used as a dental implant after sterilization product use. The invention can effectively improve the osteogenic performance of the surface of the dental implant, imitate the mechanical buffer effect of the periodontal ligament to a certain extent, reduce the local stress concentration under the state of masticatory function, and can pass through the complex bone interface structure of the dental implant, Significantly reduce the occurrence and progression of inflammation around dental implants, and improve the long-term success rate of dental implant restoration.

Disclosed is a complex including at least one lactoferrin and at least one silica having a specific surface area included between 100 m2 / g and 1000 m2 / g (BET area, measured according to standard ISO 9277-2010), the complex being obtainable by adding the lactoferrin to the silica in the form of a sol-gel with an aqueous solvent, and subsequent drying of the sol-gel. The complex is particularly suitable for use in oral care products, in particular toothpastes, mouthwashes, gels, chewing gum, tablets for use in oral care, gingival dyes, and the like. The complex features a high level of stability and bio-availability, such that it has an effective, long-lasting antibacterial and antioxidant action within the oral cavity. The complex is particularly suitable for the prevention or treatment of diseases of dental apparatus, in particular for the prevention or treatment of periodontitis or peri-implantitis, preferably in patients suffering from diabetes.

Described herein is a bifunctional peptide, compositions comprising the same, and methods useful for treatment of peri-implant disease.

The invention provides a dental implant system. The dental implant system comprises an abutment provided with a connecting assembly and an implant, wherein the implant is provided with a cavity structure matched with the connecting assembly, and the abutment is detachably and fixedly arranged at the near end of the implant through the connecting assembly; the implant comprises an implant base bodyand a sleeve body assembly part extending towards the near end along the near end face of the implant base body; and the dental implant assembly further comprises a split sleeve with a hollow structure, the split sleeve is slidably connected to the outer wall surface of the sleeve body assembly part in a sleeving mode, and the split sleeve and the abutment are relatively and fixedly arranged. Thedetachable split sleeve connected with the abutment is arranged on the outer wall of the near end of the implant, so that the problem that in clinic, scraping treatment of peri-implant inflammation is inconvenient is solved.

A self-film-forming composition in powder form, a reconstituted formula and a kit for oral use are provided, which allow an adequate colonization of the probiotic in the oral cavities together with a sufficient residence time to allow beneficial effects against the pathogens related with oral conditions. Thus, the items provided are useful for the prevention and / or treatment of a condition related to alterations of the oral microbiota, and specifically for peri-implantitis. The self-film-forming composition in powder form comprises at least a gelifier agent and / or at least a bioadhesive agent, and at least one lactic acid bacteria strain.

The invention relates to the technical field of biological materials, in particular to an implant material applicable to osteoporosis patients as well as a preparation method and application thereof.The implant material comprises a TiO2 coating, biological trace element components are doped in the TiO2 coating, the mass percentage of the TiO2 coating is 74%-78%, and the mass percentage of the biological trace element components is 22%-28%. The biological trace element components are selected from strontium and / or zinc. The implant material disclosed by the invention is a material capable of promoting osseointegration and bone regeneration around the implant material, and the concentration of zinc and / or strontium on the surface of the implant is optimized, so that the implant material hasa good antibacterial effect while promoting osteoporosis osteogenesis and implant osseointegration, and implant treatment failure caused by possible poor osseointegration and peri-implantitis after the implant material is implanted into an osteoporosis patient is prevented.

The invention provides a detachable soft tissue horizontal implant and a dental implant system with the same. The detachable soft tissue horizontal implant comprises an implant base body and a gingivapenetrating lantern ring; the implant base body comprises a bone penetrating part buried in alveolar bone, a gingival penetrating part extending to the near end is arranged on the near end surface ofthe bone penetrating part, and the gingival penetrating part is buried in gingival soft tissues; and the gingiva penetrating lantern ring is of a hollow structure and detachably sleeves a fixed position of the outer wall of the gingiva penetrating part. The soft tissue horizontal implant is designed to be a structure that the detachable implant base body is separated from the gingiva penetratinglantern ring, and solves the problem that inflammation around the implant is inconvenient to remove clinically.