35 results about "Optical coherence elastography" patented technology

A method of using an integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PR-ARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT method, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies to distinguish tissues with varying stiffness, to identify tissues with different biomechanical properties and to measure structural and mechanical properties simultaneously.

An apparatus and method of using an optical coherence elastography (OCE) under acoustic radiation force (ARF) excitation includes the steps of inducing an excitation wave in a blood sample by use of an ultrasound beam from an ultrasonic transducer; measuring an elastic property of the blood sample by use of an optical coherence tomography (OCT) beam transverse to the ultrasound beam to dynamically measure the elastic property of the blood sample during coagulation and assessing the clot formation / dissolution kinetics and strength.

A miniature quantitative optical coherence elastography system with an integrated Fabry-Perot force sensor for in situ elasticity measurement of biological tissue is provided. The technique has great potential for biomechanics modeling and clinical diagnosis. The qOCE system contains a fiber-optic probe that exerts a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography signal detected by a spectral domain optical coherence tomography engine, probe deformation in proportion to the force applied is quantified, as well as the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allows for calculation of Young's modulus from the biological tissue. The provided system has had its effectiveness validated on tissue mimicking phantoms, as well as biological tissues, with the advantages of being minimal invasive and also not requiring the use of external agents or substantial pre-measuring preparation.

The invention discloses a detection device capable of integrating stimulated Brillouin scattering and optical coherent elastic imaging. The detection device comprises a stimulated Brillouin scatteringmeasuring branch and an optical coherent elastic imaging measuring branch. Single longitudinal mode horizontal polarized light is output by a laser, passes through a polarizing beam splitter and a quarter-wave plate sequentially and then is changed into circularly polarized light, the circularly polarized light is reflected by a totally reflecting mirror and is focused into a sample by a lens tostimulate stimulated Brillouin scattering, a scattered signal returns along a back direction by the phase conjugate characteristic, passes through the quarter-wave plate again, is changed into vertical polarization, is reflected by the polarizing beam splitter and the totally reflecting mirror and then passes through a lens, a filter and an F-P standard tool sequentially, and an ICCD signal acquisition system acquires a stimulated Brillouin scattering signal. The detection device has the following advantages: a fingerprint identification database for different sample detection is established by combining absorption spectral features corresponding to different detection samples as well as the bulk modulus, the shear elasticity and the viscosity information of the samples, and an effective method and technology for rapidly detecting various samples is formed finally.

The invention provides a Brillouin scattering and optical coherent elastic imaging in-situ detection method. According to the method, a wavelength division multiplexing method and a confocal optical path are adopted to integrate a Brillouin scattering elastic imaging system and an optical coherent elastic imaging system, then the two detection systems can perform imaging detection without mutual influences through a time sequence control system of a computer, and therefore in-situ detection of a bulk elasticity modulus and a shear elasticity modulus of a sample can be completed under the condition of not moving the sample. The method has the advantages that comparative research of the two elasticity moduli can provide technical support for diagnosis and early prevention of numerous clinical diseases; and the method has important significance and value for diagnosis, treatment and prevention of multiple clinical diseases currently and especially multiple eye diseases.

The invention discloses a method for measuring the elasticity modulus of an in-vivo human cornea based on a jet-propelled optical coherence elasticity imaging technology. Doppler images of different cross sections of an in-vivo corneal tissue are acquired by using an optical coherence tomography (OCE) technology; elastic wave information in the cornea tissue is extracted through a human eye eyeball movement artifact correction algorithm; and the elasticity modulus of the cornea tissue is estimated according to a lamb wave model. Therefore, a problem that in-vivo human cornea elasticity imagingis difficult to realize through the existing OCE is solved.

The invention discloses an optical coherent elastic imaging method and a device. The optical coherent elastic imaging method uses an ultrasonic sound beam to induce a sample to be tested to generate afirst elastic wave and a second elastic wave perpendicular to a vertical propagation direction, so that when the optical coherence tomography method is used for imaging the first elastic wave and thesecond elastic wave, an imaging result containing elastic information in the first direction and the second direction can be obtained, so that the elastic information of the to-be-tested sample in the first direction and the elastic information of the to-be-tested sample d in the second direction can be obtained according to the imaging result, the purpose of measuring the axial and lateral elastic information of the tested sample is realized, and the purpose of comprehensive and accurate evaluation of the anisotropic elastic characteristics of the tested sample is realized.

The invention discloses an optical coherence elastography (OCE) device. The device induce vibration by using ultrasound beams in a sample, vibration in the sample is detected by an imaging device, coupling of a detection light beam and the ultrasound beam is realized through a coupling unit, particularly, the coupling unit comprises a sound reflection surface and a light incidence surface, the sound reflection surface has an optical transparency characteristic and a sound reflection characteristic, so that the detection light beam from the light incidence surface can be transmitted to the to-be-detected sample through the light incidence surface and the sound reflection surface, the ultrasound beam from the light incidence surface is reflected by the sound reflection surface and then transmitted to the to-be-detected sample with the detection light beam in the same direction, same-side incidence of the ultrasound beam and the detection light beam is realized, and the vibration detection sensitivity can be improved. Besides, the device requires no preparation of an annular ultrasound transducer, cannot limit the spreading range of the detection light beam or ultrasound, and bad effects of weaker sound field intensity or light field intensity on the detection sensitivity are avoided.

Retinal diseases, such as age-related macular degeneration (AMD), are the leading cause of blindness in the elderly population. Since no known cures are currently present, it is crucial to diagnose the condition in its early stages so that disease progression is monitored. Systems and methods for detecting and mapping the mechanical elasticity of retinal layers in the posterior eye are disclosed herein. A system including confocal shear wave acoustic radiation force optical coherence elastography (SW-ARF-OCE) is provided, wherein an ultrasound transducer and an optical scan head are co-aligned to facilitate in-vivo study of the retina. In addition, an automatic segmentation algorithm is used to isolate tissue layers and analyze the shear wave propagation within the retinal tissue to estimate mechanical stress on the retina and detect early stages of retinal diseases based on the estimated mechanical stress.

An apparatus and method of using an optical coherence elastography (OCE) under acoustic radiation force (ARF) excitation includes the steps of inducing an excitation wave in a blood sample by use of an ultrasound beam from an ultrasonic transducer; measuring an elastic property of the blood sample by use of an optical coherence tomography (OCT) beam transverse to the ultrasound beam to dynamically measure the elastic property of the blood sample during coagulation and assessing the clot formation / dissolution kinetics and strength.

The invention relates to a sensor, an imaging system and an imaging method applied to optical coherence elastography, and the sensor comprises a rigid piece which is internally provided with a mounting hole in a penetrating manner; a light transmitting piece is positioned in the mounting hole; an elastic connecting piece is arranged between the light transmitting part and the rigid piece; wherein an abutting part is arranged on the light transmitting piece in a protruding manner, and the abutting part is higher than the elastic connecting piece and the light transmitting piece; and when the abutting part abuts against the sample, the elastic connecting piece deforms to enable the light-transmitting piece to move, and the mechanical characteristics of the sample are obtained by collecting the optical characteristic change of the light emitted by the light transmitting piece. The sensor can realize integration of elastic modulus quantitative analysis and imaging, is good in imaging effect, facilitates elastic modulus analysis, and is convenient and fast.

The invention relates to a retina operation auxiliary device, in particular to a retina operation auxiliary device based on an optical coherence elastic imaging system. The technical problem to be solved is to provide the retina operation auxiliary device based on the optical coherence elastic imaging system, which can automatically open eyelids of a patient and can fix the body of the patient. The retina operation auxiliary device based on the optical coherence elastic imaging system comprises a supporting bed board, a positioning bottom frame, a buffering hinge frame, a damping bed board, a sponge mat and the like, the buffering hinge frame is arranged on the upper portion of the positioning bottom frame in a sliding mode, and the supporting bed board is rotationally arranged on the upper portion of the buffering hinge frame, a damping bed plate is arranged inside the supporting bed plate. Through cooperation of the driving mechanism and the limiting mechanism, the shoulder of a patient can be fixed, medical staff can conveniently conduct a cornea operation on the patient, and the situation that the operation is affected due to movement of the upper body of the patient is avoided.

The proposed combination device combines any tonometric metrology with a drug application to administer glaucoma medication on an eye. Several technical concepts are proposed and exemplary embodiments for rebound tonometry and air-puff tonometry are shown. However other methods such as optical coherence elastography (OCE) could also be used. The Solutions provide home care tonometry offerings which host the capability to administer glaucoma medication.

The invention relates to a detection device, in particular to a three-dimensional optical coherence elastography detection device applied to corneal refractive surgery. The purpose of the present invention is to provide a three-dimensional optical coherence elastography detection device for corneal refractive surgery that can avoid contamination of contaminants on the convex lens and has high working efficiency. The present invention provides such a three-dimensional optical coherence elastography detection device applied to corneal refractive surgery, comprising a detection box and a buffer base, the bottom of the detection box is provided with a plurality of buffer bases at intervals; a light-shielding cover, the detection box The top side is provided with a shading cover; the protective cover is provided with a protective cover on one side of the detection box; the start button is provided with a start button on the upper side of the detection box. Through the cooperation of the material conveying mechanism and the detection mechanism, the present invention can automatically transmit and detect the light transmittance of the convex lens, without the need for people to hold the convex lens by hand and avoid affecting the light transmittance test.

The invention relates to a device for measuring intraocular pressure, in particular to a device for measuring the intraocular pressure based on optical coherence elastography. The device for measuring the intraocular pressure based on the optical coherence elastography has the advantages that the measurement precision is high, the deformation of eyes can be refracted to an elastography photo when gas is sprayed to the eyes, and accurate data of the intraocular pressure can be more intuitively seen. The device for measuring the intraocular pressure based on the optical coherence elastography comprises bottom feet and a fixing frame, the bottom feet are arranged at the four corners of the bottom of the fixing frame, and the fixing frame is of a left-right hollow structure. Through the principle of elastography, information refracted by the eyes is converted into a visible light image, namely an imaging picture, which is habitual to a doctor, then a broadband light source is refracted to the imaging picture, and the visible light image and the imaging picture are overlapped, so that the doctor can judge an intraocular pressure result through the imaging picture.

a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.

The invention relates to a corneal removal amount device, in particular to a device for evaluating the corneal removal amount in a refractive operation through optical coherence elastography. The technical problem of the invention is to provide the device for evaluating the corneal removal amount in the refractive operation through optical coherence elastography, which can fix the position of a lens and can prevent the cornea of a patient from being hurt by too strong light. The device for evaluating the corneal removal amount in the refractive operation through optical coherence elastography comprises a first supporting framearranged on one side of a fixing frame and the fixing frame, a concave mirror frame arranged on the first support frame in a sliding manner, and a convex mirror frame arranged on the first support frame in a sliding manner and arranged on one side of the concave mirror frame. Through cooperation of the concave mirror frame, the convex mirror frame, a shading mechanism and a buffer mechanism, the medical staff can detect the cornea thickness of a patient more conveniently, external light can be shielded, and the detection result is more accurate.

A method for non-invasive measurement of corneal viscoelasticity based on jet optical coherence elastography technology, which uses pulsed airflow to induce corneal deformation, and detects the propagation of elastic waves in the cornea by Phs‑OCT. In addition to the propagation speed, the center of the elastic wave is also extracted. The wavelength and the energy attenuation coefficient during propagation to estimate the viscoelasticity of the corneal tissue. The invention makes full use of the propagation characteristics of elastic waves. In addition to estimating the elastic modulus of the soft tissue by using the propagation velocity of the elastic wave, it also comprehensively uses the energy attenuation coefficient and the central angular frequency of the elastic wave to extract the viscosity coefficient of the soft tissue, and uses the elastic wave energy attenuation. The elastic wave energy attenuation coefficient is extracted by curve fitting; at the same time, the two-dimensional Fourier transform of the phase information at different locations and different times is performed to obtain the spatial spectrum information, so as to extract the central angular frequency of the elastic wave; The energy attenuation coefficient and the center angular frequency are combined to estimate the soft tissue viscosity coefficient.

The invention relates to a detection device, in particular to a three-dimensional optical coherence elastography detection device applied to a retina operation. The three-dimensional optical coherence elastography detection device applied to the retina operation, which is convenient for people to detect coherence elastography and can clean an image slice, needs to be designed. The three-dimensional optical coherence elastography detection device applied to the retina operation comprises a shading bottom box, wherein a supporting base is arranged on one side of the shading bottom box; a sealing cover plate which is mounted on the shading bottom box in a hinged manner; and a partition plate which is mounted on the shading bottom box. Through cooperation of the driving mechanism and the detection mechanism, the image slice moves backwards by a certain distance to block a light propagation path of the first photoelectric sensor, the first photoelectric sensor sends a signal, and the control module transmits detection data after receiving the signal, so that people can conveniently detect coherent elastography.

The invention relates to auxiliary equipment, in particular to optical coherence elastic imaging auxiliary equipment for a retina operation. The invention aims to provide the optical coherence elastic imaging auxiliary equipment for the retina operation, which can reduce the workload of a doctor and prevent an imaging result from being influenced. According to the technical scheme, the optical coherence elastic imaging auxiliary equipment for the retina operation comprises a fixing support, fixing handles, a super-radiation light-emitting diode, an X-type optical fiber coupler, a detector, a supporting moving mechanism and a lens focusing mechanism, the fixing handles are symmetrically arranged on one side of the fixing support, the super-radiation light-emitting diode is arranged on the fixing support, and the X-type optical fiber coupler is arranged on the X-type optical fiber coupler. An X-type optical fiber coupler is arranged on one side of the fixing support, and a detector is arranged on one side of the super-radiation light-emitting diode. Output shafts of the first gear motor and the second gear motor drive a sponge cushion to rotate inwards, so that the sponge cushion clamps the head of the patient, and the phenomenon that the head of the patient shakes and affects the imaging result is avoided.

The invention relates to a detection device, in particular to a three-dimensional optical coherence elastography detection device applied to a corneal refractive operation. The invention aims to provide the three-dimensional optical coherence elastography detection device applied to the corneal refraction operation, the device can prevent a convex lens from being contaminated by impurities and is relatively high in working efficiency. The three-dimensional optical coherence elastography detection device applied to the corneal refraction operation comprises a detection box body, buffer bases, a shading cover plate, a protection cover and a start button. The multiple buffer bases are arranged at the bottom of the detection box body at intervals, the shading cover plate is arranged on one side of the top of the detection box body, the protection cover is arranged on one side of the detection box body, and the start button is arranged on one side of the upper portion of the detection box body. According to the three-dimensional optical coherence elastography detection device applied to the corneal refraction operation, through cooperation of a material conveying mechanism and a detection mechanism, a convex lens can be automatically conveyed and subjected to light transmittance detection, people do not need to hold the convex lens with hands, and light transmittance detection is prevented from being affected.

The invention discloses an Airy beam ultra-deep optical coherence elastography system device, and relates to the technical field of elastography. The Airy beam ultra-deep optical coherence elastography system device comprises two groups of supporting cylinders and adjusting blocks, wherein a second screw rod is mounted between the two groups of adjusting blocks, a sliding block sleeves the outer side of the second screw rod, and a control mechanism is mounted at the top end of the sliding block; and the bottom end of the sliding block is connected with a fine adjustment air cylinder, and a power supply mechanism is mounted at the output end of the fine adjustment air cylinder. According to the Airy beam ultra-deep optical coherence elastography system device, movable sliding rails, a probe, the power supply mechanism and a power connection strip are arranged, power is supplied to the probe through a power connection plate, the probe operates normally to inspect eyeballs, when different positions need to be inspected, a second motor is started, the second motor drives an output shaft and a clamping gear to rotate, the clamping gear drives belts to rotate through clamping teeth, and the belt drives a clamping plate to slide in the movable sliding rails through the clamping teeth and an insertion rod, so that the angle and the position between the probe and the eyeball are changed, and inspection is facilitated.

The invention relates to a device for detecting crystalline lens elasticity imaging, in particular to a device for detecting crystalline lens elasticity through optical coherence elastography The device for detecting crystalline lens elasticity through optical coherence elastography is good in comfort level and accurate in detection result. The device for detecting elasticity of crystalline lens through optical coherence elastography comprises a base, first sliding rods, a sliding block, a first support, a first sliding sleeve, a connecting block, a hollow frame, a mark block and a marking rod, the first sliding rods are symmetrically arranged on the base, the sliding block is slidably connected between the upper portions of the two first sliding rods, and the first support is arranged on the upper portion of the sliding block; a first sliding sleeve is arranged on the upper portion of the sliding block, a marking rod is slidably connected between the first support and the first sliding sleeve, a hollow frame is arranged on the upper portion of the first support, and a marking block is slidably arranged in the hollow frame. By arranging the buffering mechanism, the comfort degree of crystalline lens elasticity detection is improved.

The invention provides a method for in-situ detection of Brillouin scattering and optical coherence elastography, which uses the method of wavelength division multiplexing and confocal optical path to integrate the Brillouin scattering elastography system and the optical coherence elastography system, and then passes The timing control system of the computer can realize the imaging detection of the two detection systems without affecting each other, so that the in-situ detection of the bulk elastic modulus and shear elastic modulus of the sample can be completed without moving the sample position . The invention has the advantages that the comparative study on the two elastic moduli can provide technical support for the diagnosis and early prevention of many clinical diseases. This has important significance and value for the diagnosis, treatment and prevention of various diseases in clinical practice, especially multiple ophthalmic diseases.

The invention relates to an image fusion device, in particular to an image fusion device based on optical coherence elastography. The image fusion device based on optical coherence elastography, which is convenient for people to switch light sources, easy to operate and capable of limiting image sheets, needs to be designed. The image fusion device based on optical coherence elastography comprises a fixed top box, wherein a heat dissipation box body is arranged in the fixed top box in a sliding mode; a light-transmitting film which is mounted on the heat dissipation box body; and the fixed top box is mounted between the heat dissipation box body and a shading top plate. Through cooperation of the image detection mechanism and the switching mechanism, a servo motor is started, a movable gear rotates reversely to be matched with a fixed rack to enable a detection light source module to move up and down, an electric control motor is started, a driven gear ring rotates by 120 degrees to drive the detection light source module to rotate by 120 degrees for adjustment, and thus people can conveniently adjust the light source, and operation is easy.

The invention relates to cornea three-dimensional detection equipment, and particularly relates to cornea three-dimensional detection equipment based on an optical coherence elastography principle. The cornea three-dimensional detection equipment based on the optical coherence elastography principle is easy to operate, the working mode is optimized, and therefore the labor cost is reduced; meanwhile, the position of a lens can be adjusted, and the equipment is suitable for various eye distances. The cornea three-dimensional detection equipment based on the optical coherence elastography principle comprises a main frame, a switch key, an imager, guide pipes and a sliding mechanism, the sliding mechanism is arranged on the upper portion of the main frame, the starting switch key is arranged on the sliding mechanism, the imager is arranged in the sliding mechanism in a sliding mode, and the guide pipes are symmetrically arranged on the sliding mechanism in a sliding mode. A permanent magnet is attracted to a limiting block, and therefore the opening state of a display screen is fixed; in cooperation with reading and observation of data, after the equipment is used, the display screen can be pushed to rotate and be recycled, and the display screen is prevented from being collided and damaged.

A method for measuring the elastic modulus of the human cornea in vivo based on jet optical coherence elastography technology, using optical coherence elastography (optical coherence elastography, OCE) to collect Doppler images of different cross-sections of in vivo corneal tissue, The elastic wave information in the corneal tissue is extracted through the human eye movement artifact correction algorithm, and the elastic modulus of the corneal tissue is estimated according to the Lamb wave model, which solves the problem that the existing OCE is difficult to achieve in vivo human corneal elastography.

The present invention relates to a sensor, an imaging system and an imaging method applied to optical coherent elastography, comprising: a rigid part, an installation hole is opened inside the rigid part; a light-transmitting part, the light-transmitting part is located in the installation hole Inside: an elastic connecting piece, which is arranged between the light-transmitting piece and the rigid piece; wherein, a pressing portion protrudes from the light-transmitting piece, and the pressing portion is higher than the elastic connecting piece and a light-transmitting member; when the pressing portion presses against the sample, the elastic connecting member deforms to displace the light-transmitting member, and obtains the mechanical properties of the sample by collecting the optical characteristic change of the light emitted by the light-transmitting member. It can realize the integration of elastic modulus quantitative analysis and imaging, has good imaging effect, is convenient for elastic modulus analysis, and is convenient and convenient.