A method for non-invasive measurement of corneal viscoelasticity based on jet optical coherence elastography

Abstract

A method for non-invasive measurement of corneal viscoelasticity based on jet optical coherence elastography technology, which uses pulsed airflow to induce corneal deformation, and detects the propagation of elastic waves in the cornea by Phs‑OCT. In addition to the propagation speed, the center of the elastic wave is also extracted. The wavelength and the energy attenuation coefficient during propagation to estimate the viscoelasticity of the corneal tissue. The invention makes full use of the propagation characteristics of elastic waves. In addition to estimating the elastic modulus of the soft tissue by using the propagation velocity of the elastic wave, it also comprehensively uses the energy attenuation coefficient and the central angular frequency of the elastic wave to extract the viscosity coefficient of the soft tissue, and uses the elastic wave energy attenuation. The elastic wave energy attenuation coefficient is extracted by curve fitting; at the same time, the two-dimensional Fourier transform of the phase information at different locations and different times is performed to obtain the spatial spectrum information, so as to extract the central angular frequency of the elastic wave; The energy attenuation coefficient and the center angular frequency are combined to estimate the soft tissue viscosity coefficient.

Description

technical field [0001] The invention specifically relates to the technical field of optical coherence elastography, in particular to a method for non-invasively measuring corneal viscoelasticity based on jet optical coherence elastography. Background technique [0002] Corneal tissue is a viscoelastic material with both viscous and elastic properties, which can be characterized by biomechanical parameters such as elastic modulus and viscosity coefficient. Existing studies have found that corneal mechanical properties can assist in the early diagnosis of certain ophthalmic diseases (such as keratoconus, Fuchs corneal degeneration, etc.) and guide corneal-related operations (such as corneal refractive surgery, corneal cross-linking surgery, etc.). [0003] Optical Coherence Elastography (OCE) is based on Optical Coherence Tomography (OCT), which uses biomechanical parameters such as elastic modulus, shear modulus, and viscosity coefficient of soft tissue as imaging objects. T...

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Problems solved by technology

[0018] In order to solve the existing OCE based on amplitude comparison, or elastic wave, or resonance frequency, since the viscosity coefficient of soft tissue is much smaller than the elastic modulus, it is ignored, and finally only the elastic modulus of soft tissue can be estimated, which cannot be comprehensive Reflecting the defects of the biomechanical properties of soft tissues, the present invention provides a method for non-invasive measurement of corneal viscoelasticity based on jet optical coherent elastography

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