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Non-invasive measurement method of corneal viscoelasticity based on jet optical coherence elastic imaging technology

An optical coherence, elastography technology, applied in diagnostic recording/measurement, medical science, sensors, etc., can solve problems such as the inability to fully reflect the biomechanical properties of soft tissues

Active Publication Date: 2019-06-14
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0018] In order to solve the existing OCE based on amplitude comparison, or elastic wave, or resonance frequency, since the viscosity coefficient of soft tissue is much smaller than the elastic modulus, it is ignored, and finally only the elastic modulus of soft tissue can be estimated, which cannot be comprehensive Reflecting the defects of the biomechanical properties of soft tissues, the present invention provides a method for non-invasive measurement of corneal viscoelasticity based on jet optical coherent elastography

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  • Non-invasive measurement method of corneal viscoelasticity based on jet optical coherence elastic imaging technology
  • Non-invasive measurement method of corneal viscoelasticity based on jet optical coherence elastic imaging technology
  • Non-invasive measurement method of corneal viscoelasticity based on jet optical coherence elastic imaging technology

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Embodiment Construction

[0058] Combine now figure 1 To further illustrate the present invention, the present invention is based on jet optical coherence elastography technology to non-invasively measure corneal viscoelasticity, mainly including Phs-OCT system construction, integration of jet device and Phs-OCT system, corneal biomechanical mathematical model construction and corneal viscoelasticity. Viscoelasticity Estimation.

[0059] (1) Construction of Phs-OCT system, integration of air jet device and Phs-OCT system: Air pulse and Phs-OCT detection need to act on corneal tissue at the same time, so the synchronous integration of air jet device and Phs-OCT probe is the key. The present invention adopts oblique incidence integration mode structurally (such as figure 1 ), that is, the jet emission probe forms an included angle with the long axis of the Phs-OCT scanning probe. At the signal control level, Phs-OCT drives the galvanometer working signal as the trigger signal of the valve switch of the...

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Abstract

The invention relates to a non-invasive measurement method of corneal viscoelasticity based on a jet optical coherence elastic imaging technology. The pulsed airflow is used to induce deformation of the cornea, the propagation condition of elastic waves in the cornea is detected by Phs-OCT, and in addition to the propagation velocity, a central wavelength of the elastic wave and an energy attenuation coefficient during propagation are extracted to estimate the viscoelasticity of the corneal tissue. The method fully utilizes the propagation characteristics of the elastic wave, and uses the elastic wave propagation velocity to estimate the elastic modulus of the soft tissue, and comprehensively utilizes the energy attenuation coefficient and a central angular frequency of the elastic wave toextract the viscosity coefficient of the soft tissue, the elastic wave energy attenuation characteristics is used, and the elastic wave energy attenuation coefficient is extracted by curve fitting. At the same time, the phase information at different sites and different times is subjected to two-dimensional Fourier transform to obtain spatial spectrum information, and the central angular frequency of the elastic wave can be extracted; and the elastic wave energy attenuation coefficient and the central angular frequency are combined to estimate the soft tissue viscosity coefficient.

Description

technical field [0001] The invention specifically relates to the technical field of optical coherence elastography, in particular to a method for non-invasively measuring corneal viscoelasticity based on jet optical coherence elastography. Background technique [0002] Corneal tissue is a viscoelastic material with both viscous and elastic properties, which can be characterized by biomechanical parameters such as elastic modulus and viscosity coefficient. Existing studies have found that corneal mechanical properties can assist in the early diagnosis of certain ophthalmic diseases (such as keratoconus, Fuchs corneal degeneration, etc.) and guide corneal-related operations (such as corneal refractive surgery, corneal cross-linking surgery, etc.). [0003] Optical Coherence Elastography (OCE) is based on Optical Coherence Tomography (OCT), which uses biomechanical parameters such as elastic modulus, shear modulus, and viscosity coefficient of soft tissue as imaging objects. T...

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Application Information

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IPC IPC(8): A61B5/00
Inventor 朱德喜金梓周煜恒沈梅晓王媛媛吕帆
Owner WENZHOU MEDICAL UNIV
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