A method for in situ detection of Brillouin scattering and optical coherence elastography

Abstract

The invention provides a method for in-situ detection of Brillouin scattering and optical coherence elastography, which uses the method of wavelength division multiplexing and confocal optical path to integrate the Brillouin scattering elastography system and the optical coherence elastography system, and then passes The timing control system of the computer can realize the imaging detection of the two detection systems without affecting each other, so that the in-situ detection of the bulk elastic modulus and shear elastic modulus of the sample can be completed without moving the sample position . The invention has the advantages that the comparative study on the two elastic moduli can provide technical support for the diagnosis and early prevention of many clinical diseases. This has important significance and value for the diagnosis, treatment and prevention of various diseases in clinical practice, especially multiple ophthalmic diseases.

Description

technical field [0001] The invention relates to an imaging detection method of elastic modulus of biological tissue, in particular to a method capable of realizing in-situ detection of Brillouin scattering and optical coherence elastic imaging. Background technique [0002] At present, Brillouin scattering elastography and optical coherence elastography are the latest methods to detect the elastic properties of biological tissue. The physical principles of the two are different, and the bulk elastic modulus and shear elastic modulus of biological tissue can be obtained respectively. This is important for some clinical The diagnosis and treatment of diseases, especially eye diseases (myopia, keratoconus, etc.) are of great significance. But there are still some technical limitations in the research on Brillouin scattering elastography and optical coherence elastography. [0003] In clinical practice, some chronic diseases, especially ophthalmological myopia, presbyopia or ca...

AI Technical Summary

Problems solved by technology

But there are still some technical limitations in the research on Brillouin scattering elastography and optical coherence elastography

[0003] In clinical practice, some chronic diseases, especially ophthalmological myopia, presbyopia or cataract, often cannot be directly judged in the early stage whether the disease occurs, and the elastic detection method can be used to detect whether the nature of the tissue has occurred from a biomechanical point of view. Pathological changes, so the means of elastic detection is needed to obtain the elastic properties of the tissue, but other technical means cannot achieve such high precision as optical means, and the use of optical means is a non-destructive means

The reason for the comparison is that the shear elastic modulus and the bulk elastic modulus are the classical physical quantities that we consider to characterize the elastic properties of the sample, but because the magnitudes of the two elastic moduli are usually much different, it is impossible to use the same system to do Therefore, our patent can achieve this problem. The advantage of this is that we can analyze how the elasticity of the tissue changes from the two moduli, or we can determine which of the two elastic moduli is more suitable for use. Clinically, the detection of elastic properties of biological tissues is very different. At present, there is no technical means that can realize the detection of two elastic moduli at the same time, let alone the comparative study of the two elastic moduli.

Images