A method for measuring corneal elastic modulus in vivo based on jet optical coherence elastography

An optical coherence and elastography technology, used in eye testing equipment, medical science, diagnosis, etc., can solve the lack of human eye movement artifact correction algorithms, the inability to popularize and apply the algorithm, and the in vivo human corneal tissue elasticity has not been obtained. Modulus etc.

Active Publication Date: 2022-01-07
WENZHOU MEDICAL UNIV
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Problems solved by technology

Air-coupled ultrasonic radiation force induces very small deformation of corneal tissue, which is not easy to cause overall eye movement, while micro-air pulse excitation can cause large corneal deformation accompanied by overall eye movement; in addition, the research objects were rabbits after anesthesia , the algorithm only considers the interference of eyeball axial movement artifacts, but in fact, clinical subjects have the interference of eyeball horizontal movement artifacts, so it is still not possible to directly apply the algorithm to clinical practice
[0010] Due to the lack of human eye movement artifact correction algorithm for jet OCE in the prior art, the elastic modulus of human corneal tissue in vivo has not yet been obtained

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  • A method for measuring corneal elastic modulus in vivo based on jet optical coherence elastography
  • A method for measuring corneal elastic modulus in vivo based on jet optical coherence elastography
  • A method for measuring corneal elastic modulus in vivo based on jet optical coherence elastography

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Embodiment Construction

[0035] The present invention will be further described below in conjunction with specific embodiments. The embodiments of the present invention are intended to enable those skilled in the art to better understand the present invention, but do not limit the present invention in any way.

[0036] The present invention is based on jet optical coherent elastography technology to realize the elastic imaging of human corneal tissue in vivo, mainly including Phs-OCT system construction, integration of jet device and Phs-OCT system, human eye movement artifact correction and Lamb The wave model was used to solve the elastic modulus of corneal tissue.

[0037] (1) Phs-OCT system construction: Phs-OCT is based on the interference spectrum signal collected by structural OCT, which is converted into phase information after data processing, so as to reflect the degree of deformation with high precision.

[0038] The balanced detector obtains the interference spectral intensity I(λ), after ...

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Abstract

A method for measuring the elastic modulus of the human cornea in vivo based on jet optical coherence elastography technology, using optical coherence elastography (optical coherence elastography, OCE) to collect Doppler images of different cross-sections of in vivo corneal tissue, The elastic wave information in the corneal tissue is extracted through the human eye movement artifact correction algorithm, and the elastic modulus of the corneal tissue is estimated according to the Lamb wave model, which solves the problem that the existing OCE is difficult to achieve in vivo human corneal elastography.

Description

technical field [0001] The invention specifically relates to the technical field of optical coherence elastography, in particular to a method for measuring the elastic modulus of human cornea in vivo based on jet optical coherence elastography technology. Background technique [0002] Corneal tissue is a viscoelastic material with both viscous and elastic properties, which can be characterized by biomechanical parameters such as elastic modulus and viscosity coefficient. Existing studies have found that corneal mechanical properties can assist in the early diagnosis of certain ophthalmic diseases (such as keratoconus, Fuchs corneal degeneration, etc.) and guide corneal-related operations (such as corneal refractive surgery, corneal cross-linking surgery, etc.). [0003] Optical Coherence Elastography (OCE) is based on Optical Coherence Tomography (OCT), which uses biomechanical parameters such as elastic modulus, shear modulus, and viscosity coefficient of soft tissue as ima...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B3/10
CPCA61B3/102
Inventor 沈梅晓金梓陈思思周煜恒王媛媛朱德喜吕帆
Owner WENZHOU MEDICAL UNIV
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