The invention relates to application of
CART (Cocaine
Amphetamine Regulated Transcript) in preparing medicaments for treating alzheimers diseases. In the invention,
CART is prepared into injection preparations for treating alzheimers diseases, and the defects of the traditional medicaments for enhancing
cholinergic action and N-methyl-D-
aspartic acid (NMDA)
receptor antagonists are overcome. The novel medicament has
multiple target point actions on the generation and the degradation of A beta as well as the influence of the
neurotoxicity and the
molecular mechanism of the A beta. The invention has effects on effectively treating
dementia with
estrogen and up-regulating intracephalic
CART; more CARTs are distributed in intracephalic
hippocampus; CART exists in intracephalic
acetylcholine neurons and can promote the release of
acetylcholine; and mitochondrial dysfunction induced by A beta
neurotoxicity is the main pathway for the A beta to cause
neuronal apoptosis. The CART has a directaction on mitochondrial succinodehydrogenase
subunit B and can maintain the
respiration of mitochondria and the generation of energy, alleviate
oxidative stress, stabilize mitochondrial
membrane potential and prevent the mitochondria from being damaged, thereby inhibiting
apoptosis.