40 results about "Neoplasm/cancer" patented technology

The invention relates to conjugates that bind to targets, methods of using conjugates that bind to targets and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express a target.

Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of EGFR expressing tumors / cancers. Also provided are compositions comprising the compounds.

This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer.

The invention relates to a novel photosensitizer monomer completely soluble in water. Chlorophyll a is taken as a raw material for preparing pheophorbide a, 3-devinyl-3-(1'- hexahydro)ethyl-methyl pheophorbide-a is directly synthesized from pheophorbide a, and a water-soluble salt shown as the structural formula is obtained by processing with an alkali metal hydroxide. In the structural formula, R1, R2 and R3 are H or M, R1, R2 and R3 are not H simultaneously, and M is selected from Na, K or NH4<+>. The above water-soluble salts do not change the large ring structure with photosensitivity, are convenient to apply because of good water solubility, are applicable to prepare medicines for treating or diagnosing malignant tumor (especially superficial malignant tumor in all lumens), precancerous lesions and benign lesion during photodynamic therapy.

The invention relates to nucleolin binding peptides, nucleolin binding peptides and anti-nucleolin antibody conjugates with cytotoxic activity, fusion constructs, methods of using nucleolin binding peptides and antibodies and fusion constructs thereof, and methods of treating various disorders, undesirable conditions and diseases treatable with nucleolin binding peptides and fusion constructs, such as undesirable or aberrant cell proliferation (hyperproliferation) or hyperproliferative disorders, including tumors, cancers, neoplasia and malignancies, angiogenesis related or dependent diseases, and inflammatory diseases and inflammation.

In certain embodiments, this present disclosure provides compositions and methods for detecting EphB4 gene amplification in test cells. In certain embodiments, the present disclosure provides methods and compositions for evaluating tumor (cancer) status and prognosis in a subject having or suspected of having a tumor.

The invention discloses traditional Chinese medicine liquor for treating tumors and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine liquor mainly comprises more than 60 kinds of traditional Chinese medicines including cortex juglandis mandshuricae, fructus fici, livistona chinensis (Jacq.) R.Br., trapa natans L. (quadrangular), rabdosia rubescens, spreading hedyotis herb, rhizoma smilacis glabrae, barbed skullcap herb, Indian mockstrawberrg herb and the like, and is prepared by soaking the traditional Chinese medicines in pure-grain Baijiu (55-60% vol) according to a specific ratio, a specific sequence and specific time and then filtering. The traditional Chinese medicine liquor has the advantages that the traditional Chinese medicine liquor is used for treating various tumors (cancers) and applied to other metastatic cancer treatment and is capable of strengthening the body resistance, removing evils, softening hardness to dissipate stagnation, resisting cancers, detoxifying, reinforcing the vital essence, strengthening the primordial qi, activating blood circulation to remove stagnated blood, nourishing blood, achieving hemogenesis, invigorating the stomach, tonifying the spleen, clearing blood, cooling blood and clearing heat-fire; phagocytic ability of macrophagocytes can be improved, cancer cells can be killed directly or indirectly to promote lymphocyte transformation and induce interferon, canceration inducing factors are decreased, and accordingly cancer prevention, resistance to the cancers, cancer inhibition and cancer cell apoptosis are achieved; various cancers and forming thereof as well as a series of diseases caused by the various cancers can be prevented.

The invention relates to conjugates that bind to Her2 / neu, methods of using conjugates that bind to Her2 / neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2 / neu.

The invention belongs to the technical field of cells and discloses novel adult stem cells, a method for screening the same, a kit and application thereof. Biopsy samples, in vitro tissue samples, and cell line samples of normal tissues and tumors, precancerous tissues and tumors, carcinogenic tissues and metastatic tumors or cancer tissues of rodent, human or other mammals are screened by using chemotherapeutics and cell markers which are combined so as to obtain the stem cell groups. Moreover, the invention also discloses a method for screening and identifying the stem cells from the mixed cell groups, and the kit; and the method and the kit have the advantages of strong specificity, simplicity, convenience, quickness, practicality and effectiveness. The novel stem cells, the method for screening the same and the kit can be applied to clinic treatment, basis and application research, treatment, tissue engineering, medicine screening, and repairing and regeneration of diseased tissues and organs which loose functions well, and have wide prospect.

The invention relates to conjugates that bind to targets, methods of using conjugates that bind to targets and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express a target.

This invention relates to the field of therapeutic RNAs for treatment of solid tumor cancers.

The invention provides an integrated liquid-based tumor cell intelligent sorting device and a control system. An automatic filtering and separating device is provided with a sample placing platform, a liquid-based tumor cell data extraction unit comprises a sample feeding device, a two-dimensional moving gun head and a mechanical arm, and an automatic positioning device is connected with an automatic positioning platform. One end of a conveying rail is connected with a sample conveying window, the two-dimensional moving gun head is connected with the mechanical arm, the mechanical arm is controlled to extract and collect samples and prevent inclined collection errors of the samples, the mechanical arm is arranged above the sample conveying device, the analysis and detection device is connected with an outer cabinet, and a sample retention area is arranged below the outer cabinet. According to the device, the PC control system is adopted to improve the intelligent degree, integrated analysis of the detection sample is achieved, errors are reduced to the minimum by monitoring and controlling the operation process, related equipment components can be reasonably and finely adjusted, early screening of tumor cancers is promoted, and the treatment level of tumor patients is effectively improved.

Evofosfamide (TH-302) or an analog thereof has a specific inhibitory effect on a cell having a specific gene mutation, in particular on a DNA repair-damaged cell. The cell or tissue has at least one or more gene mutations in BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2,XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP, and ERCC5. For this, a medical use of evofosfamide (TH-302) or an analog thereof in treating tumors or cancer in a cancer patient having the specific gene mutation(s) is provided.

The invention relates to a gynecological intracavity radiation therapy protection device and a radiation therapy protection method.The radiation device comprises a line concentration cylinder, a radiotherapy cylinder, a radiotherapy adjusting unit, a laser ranging unit and an image obtaining unit.The gynecological intracavity radiation therapy protection device is characterized in that a radiotherapy head is placed in the radiotherapy cylinder; on the premise that the tail end PC obtains a three-dimensional uterine cavity ultrasonic image of a patient in advance, position data measured by the laser distance measuring unit are sent to the tail end PC for data comparison and analysis, the position of the radiotherapy head is adjusted through stretching / rotating of the radiotherapy adjusting unit according to the data comparison result, and in the process, the position of the radiotherapy head is adjusted through stretching / rotating of the radiotherapy adjusting unit. The image acquisition unit uploads acquired data to the terminal PC, and position reference is performed through the terminal PC, so that the position of the radiotherapy head is adjusted more quickly and accurately, the efficiency of uterine cavity radiotherapy is improved, and damage to normal mucosa around a tumor canceration part is reduced.

The invention discloses an anti-tumor traditional Chinese medicine composition and a preparation method thereof. The anti-tumor traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12-27 parts of ramulus cinnamomi, 3-12 parts of pseudobulbus cremastrae seu pleiones, 15-45 parts of poria cocos, 10-50 parts of liquorice roots, 10-40 parts of seaweeds, 10-40 parts of radix scrophulariae, 10-40 parts of radix ranunculi ternati, 10-45 parts of concha ostreae, 10-30 parts of rhizoma sparganii, 5-15 parts of radix aucklandiae, 5-15 parts of bulbus fritillariae cirrhosae and 5-30 parts of raw rhizoma pinelliae. The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 60 parts of spica prunellae and 75 parts of herba hedyotidis diffusae. The traditional Chinese medicine composition further comprises a medicinal guide. Dialectical treatment is carried out according to the difference of affected parts of patients and the difference of clinical main symptoms, and the medicinal guide is added on the basis of an original formula. The traditional Chinese medicines are made into traditional Chinese medicine pills, because the traditional Chinese medicine pills are convenient to take, and the dosage is easy to master; anti-tumor and anti-cancer common medicines can be prepared into main medicine pills, and then different medicinal guide pills are matched according to the different tumor and cancer affected parts so as to avoid the trouble of the re-matching for the different tumor and cancer affected parts each time, such that the medicine preparation efficiency is improved; and the medicine has high-efficiency anti-tumor activity, no obvious toxic or side effect and very low drug resistance.

The invention relates to the technical field of medicine feeders, in particular to a tumor and cancer special medicine feeding device with a protection function. The tumor and cancer special medicine feeding device comprises a medicine feeder body, the medicine feeder body comprises a round block, a medicine feeding pipe and a medicine feeding head, the round block enables the internal space of a pressing cavity and the internal space of a medicine cavity to be reduced through deformation of a pressing head, negative pressure is formed in the pressing cavity and the internal space of the medicine cavity, medicine liquid in the medicine cavity is discharged through a first connector, and therefore the effect of quantitative medicine feeding is achieved; the medicine feeding pipe is arranged, by means of connection between the medicine feeding pipe and the round block, the distance of the first connector is prolonged, the distance between medical staff and a patient is increased, the effect of improving cleanliness is achieved, a medicine feeding head is arranged, the medicine liquid in a medicine feeding groove can slowly flow into the mouth of the patient through the gravity effect of the medicine feeding head, and therefore medicine feeding work is completed. According to the tumor and cancer special medicine feeding device with the protection function, the tumor and cancer special medicine feeding device with the protection function can avoid discomfort of the patient caused by the fact that the patient is choked by impact force of the medicine liquid due to overlarge extrusion force when the medicine liquid is extruded.

The present disclosure provides a data processing system and electronic equipment for acquiring the position and contour of a tumor in a CT image, acquiring a CT image, and performing image segmentation on the acquired CT image by using a particle swarm optimization algorithm to obtain a segmented CT image data matrix; Establish a QSOFM classifier model, use the segmented CT image data matrix for model training; use the QSOFM classifier model to identify the cancerous tumor types in the CT image, and obtain the location and contour of the cancerous tumor in the CT image based on the multi-connected region segmentation method Information; this disclosure makes image segmentation more detailed and reduces redundant data, which makes the automatic puncture device have a higher recognition rate of tumors in CT images, and locates the tumor position more quickly and accurately, and improves the automation of the automatic puncture device. Computer-assisted therapy lays the groundwork.

Glufosfamide or analogues thereof have specific inhibitory effects on cells with specific gene variations, specifically, DNA repairs damaged cells, the cells or tissues at least have one or more genemutations of BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP or ERCC5. The analogues are esters obtained by esterification reaction of one or more hydroxyl groups in glufosfamide molecules with organic acid and inorganic oxyacid; esters obtained by esterification reaction of one or more hydroxyl groups in glufosfamide molecules with amino acid; and salts obtained by reaction of glufosfamide molecules withan acid. Therefore, provided is medical uses of glufosfamide or the analogues thereof in treatment of tumors and cancer diseases of cancer patients with specific gene variations.

Hairless, immunodeficient mice on a non-obese diabetic (NOD) background and methods for their production are disclosed herein. The mice are hairless and have multiple immunodeficiencies, including B-cell and T-cell deficiencies, as well as impaired macrophage and complement function. The mice also have a further deficit in natural killer and dendritic cells of the immune system. The mice are useful for biomedical research, for example, in studies involving xenograft transplantation, spontaneous tumors, cancer cell tumorigenesis, tumor angiogenesis, tumor metastatic potential, tumor suppression therapy, carcinogenesis regulation, and tumor imaging.

The invention relates to the technical field of nursing boxes, in particular to a push-pull rotation type nursing box for tumor cancers. The push-pull rotation type nursing box comprises an installation device and a storage device installed in the installation device, the installation device comprises a bottom installation plate and a top installation plate, the top installation plate is fixedly connected with one end of a connecting plate, and the storage device at least comprises a first storage box and a second storage box. According to the push-pull rotation type nursing box for the tumor cancers, by arranging the first storage box and the second storage box, tools used by medical staff can be placed in an isolated mode so that cross infection between the tools can be prevented, and the problems that an existing nursing box cannot store the used tools in an isolated mode and the unused tools need to be cleaned when used next time are solved.

The invention provides anticancer medical application of evofosfamide. The evofosfamide (TH-302) or an analogue of the evofosfamide has a specific inhibiting effect on specific genetically altered cells, and specifically, cells with damaged DNA repair or tissue at least has one or more gene mutation of BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C,RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP or ERCC5. Therefore, the medical application of the evofosfamide (TH-302) or the analogue of the evofosfamide for treating tumor and cancer diseases of people with cancer of the specific gene mutation is provided.

The invention provides a biodegradable mesoporous nano magnetic material and a preparation method thereof. The present invention adopts the in-situ co-precipitation method, dissolves a certain amount of salt containing calcium, phosphate and carbonate in the aqueous solution, stirs at a constant temperature at a certain temperature, then adds a certain amount of soluble iron, cobalt, nickel and other salts, and continues the constant temperature Stir for 10s-120h, filter the product, wash with ethanol twice, dry in the air and then calcinate at 600-1200°C for 2-12h, place the product in a citric acid-sodium hydroxide buffer solution with a pH of 4.5-7.4, and continuously Stir for 30min-24h, wash the product twice with deionized water and twice with ethanol, and dry at 50-60°C to obtain a nano-mesoporous magnetic material containing nano-magnetic materials in the skeleton. The mesoporous nano-magnetic material synthesized by the method of the present invention can be used as a magnetic targeting material for directional killing of tumors and cancer tissues, and has biodegradability, can be gradually degraded and discharged in a living body, and avoids the nanoparticle in a living body accumulation enrichment.

Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

The invention relates to the technical field of sample collection, in particular to a special tumor and cancer collecting device based on constant-temperature storage and easy for sample collection. The device at least comprises a collecting mechanism, a needle head and a sample collecting mechanism, the collecting mechanism comprises a collecting cylinder, two symmetrical cavities are formed in the collecting cylinder, power devices are arranged in the cavities, a fixing disc is arranged in the inner cavity, close to the end, of the collecting cylinder, and two symmetrical communicating holes are formed in the surface of the fixing disc; two communicating holes communicate with the inside of the two cavities respectively, an adjusting gear disc is rotationally arranged on the front surface of the fixing disc, adjusting holes are formed in the surface, close to the edge, of the adjusting gear disc, the needle head comprises a connecting cylinder, the end of the connecting cylinder is in threaded fit connection with the end of the collecting cylinder, the sample collecting mechanism comprises a collecting pipe, the end of the collecting pipe is communicated with the interiors of the cavities, and a thermostatic cylinder is connected to the end of the collecting pipe. According to the device, two blood samples can be conveniently collected at the same time, and the samples can be conveniently stored at a constant temperature.

Glufosfamide or an analogue thereof has specific restraining effects on cells having particular gene variation, and specifically can repair damaged cells through DNA. The cells or tissue at least has one gene mutation or more gene mutations in BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP or ERCC5. The analogue refers to an ester which is obtained through an esterification reaction on one or more hydroxyls in glufosfamide molecules and organic acid and inorganic oxygen acid, an ester which is obtained through an esterification reaction of one or more hydroxyls in the glufosfamide molecules and amino acids, and salt which is obtained through a reaction of the glufosfamide molecules and acid. The invention provides a medical application of the glufosfamide or the analogue thereof to treatment of tumor and cancer diseases of cancer patients having particular gene variation.

The invention relates to transfer equipment, and especially relates to a transfer deck chair for tumor cancer chemotherapy. The chair comprises a turnover type supporting mechanism and a movable base arranged at the bottom of the turnover type supporting mechanism, and universal wheels for driving the movable base to move are arranged at the four corners of the bottom of the movable base. An upper hip supporting plate, a lower hip supporting plate and a hip supporting plate are kept horizontal, so that when a transfer person lies flat and needs to sit down, the upper hip supporting plate is made to stand upwards, the lower hip supporting plate is made to fall down, and the part above the hip and the part below the hip of the transfer person are supported; in addition, the upper hip supporting plate and the lower hip supporting plate are fixed through the overturning piece, so that the adjustment range of the overturning angle of the upper hip supporting plate and the lower hip supporting plate is widened.

The invention relates to a traditional Chinese medicine, in particular to a medicine which is used for treating malignant tumors and has prevention and treatment functions, and solves the problem that the modern medical circle depends on Western medicine means to treat cancers but with insignificant effect and obvious side effect. The traditional Chinese medicine consists of astragalus root, Codonopsis pilosula, honeysuckle, dandelion, bupleurum falcatum L., baikal skullcap root, radix paeoniae alba, Irkutsk anemone Rhizome, rhizoma sparganii, arisaema consanguineum schott, pinellia tuberifera, Oldenlandia diffusa, notoginseng, radix sophorae subprostratae, and radices curcumae zedoariae. The traditional Chinese medicine has the functions of prohibiting the proliferation of various cancercells and killing various cancer cells; and has obvious treatment effects to various tumors and cancers.

Improved and more robust vaccine preparations (such as cancer vaccines), and methods of treating a subject having a neoplastic cell growth, such as a cancer or tumor, are presented. A neoantigen component having one or more identified neoantigens that are overexpressed in a tumor cell or cancer cell is provided. The overexpressed neoantigens are in some examples MEW Class I neoantigens. Personalized neoantigen preparations for a subject to be used with the vaccine are also provided. Methods of screening a biological sample from a subject having a cancer or tumor to identify specific neoantigens overexpressed after treatment with the tissue vaccine are presented. A panel of neoantigens characteristic of a specific cancer or tumor is also provided. The preparations, methods and panels are provided for subjects capable of or at risk of developing a tumor, cancer, or related disease. Methods and preparations for treating malignant, pre-malignant, and at-risk subjects are also presented.

The invention discloses pills for treating the bone cancer and an application thereof. The pills are composed of the following components: 50 g of mercury, 50 g of potassium nitrate, 50 g of alum, 20g of verdigris, 15 g of chalcanthite, 25 g of yellow lead, 50 g of melanterite, 50 g of halite, 2.5 g of musk and 2.5 g of borneol. According to the pills for treating the bone cancer and the application thereof, the pills are mainly used for treating gangrene of finger or toe (angiitis), suppurative osteomyelitis (bone tuberculosis and osteomyelitis), venereal syphilis, rheumatic arthritis, rheumatoid arthritis, malignant tumor (carcinoma) and osteosarcoma (bone cancer), and have a good treatment effect.