A kind of biodegradable mesoporous nano magnetic material and preparation method thereof

A magnetic nano and inorganic nano technology, applied in biochemical equipment and methods, methods of stress stimulating microbial growth, nano-magnetism, etc., can solve the problems of high preparation conditions, uncontrollable process, difficult separation of solid and liquid, etc.

Active Publication Date: 2021-08-20
DONGGUAN UNIV OF TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN101625919A uses a sol-gel combined with hydrothermal method to obtain a nano-mesoporous magnetic material containing nano-magnetic materials in both the silica skeleton and the mesoporous channels. The preparation method uses a hydrothermal method, which requires high preparation conditions and an uncontrollable process. Moreover, the sol-gel product is nano-sized, and the solid-liquid is not easy to separate. The main carrier nano-silica is not biodegradable in the body, and it will travel around with the blood and be enriched in normal tissues of the human body, which has biological safety problems.

Method used

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  • A kind of biodegradable mesoporous nano magnetic material and preparation method thereof
  • A kind of biodegradable mesoporous nano magnetic material and preparation method thereof
  • A kind of biodegradable mesoporous nano magnetic material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0085] Embodiment 1, biodegradable mesoporous nano magnetic material Fe 3 o 4 Ca 4 (PO 4 ) 2 CO 3 preparation of

[0086] Weigh 12g of calcium nitrate, 5.77g of sodium monohydrogen phosphate and 1.29g of sodium carbonate, dissolve them in a hydrochloric acid solution with a pH of 1.0, and stir evenly at a constant temperature of 0°C. Add appropriate amount of FeCl 3 aqueous solution, so that the ratio of the number of molecules of calcium to iron is 4:1, continue to stir at 0°C for 30 minutes, then use sodium hydroxide solution to adjust the pH of the solution to 9.0, stir at high speed for 2 minutes, filter the product, and wash with deionized water twice. Washed twice with ethanol, dried at 50°C, and calcined at 800°C in air for 12 hours to obtain a dry product.

[0087] Take the product prepared above and place it in a citric acid-sodium hydroxide buffer solution with a pH of 5.5, stir continuously at 25°C for 30 min, centrifuge the product, remove the supernatant, w...

Embodiment 2

[0090] Embodiment 2, biodegradable mesoporous nano magnetic material Co 3 o 4 Ca 4 (PO 4 ) 2 CO 3 preparation of

[0091] Weigh 9g of calcium chloride, 8.24g of dipotassium hydrogen phosphate and 0.84g of sodium bicarbonate, dissolve them in a hydrochloric acid solution with a pH of 4.2, and stir evenly at a constant temperature of 25°C. Add appropriate amount of CoCl 3 aqueous solution, so that the ratio of the number of molecules of calcium to cobalt is 3:1, continue to stir at 25°C for 30min, then use potassium hydroxide solution to adjust the pH of the solution to 10.0, stir at high speed for 36h, filter the product, and wash with deionized water twice, Washed twice with ethanol, dried at 50°C, and calcined at 800°C in air for 2 hours to obtain a dry product.

[0092] The product prepared above was placed in a citric acid-sodium hydroxide buffer solution with a pH of 6.6, stirred continuously at 25°C for 6 hours, the product was centrifuged, the supernatant was remo...

Embodiment 3

[0095] Embodiment 3, biodegradable mesoporous nano magnetic material Ni 2 o 3 Ca 4 (PO 4 ) 2 CO 3 preparation of

[0096] Weigh 9g of calcium chloride, 8.24g of dipotassium hydrogen phosphate and 0.84g of sodium bicarbonate, dissolve them in a hydrochloric acid solution with a pH of 3.2, and stir evenly at a constant temperature of 100°C. Add appropriate amount of NiCl 2 Aqueous solution, so that the ratio of calcium to nickel molecules is 4:1, continue to stir at 100°C for 30 minutes, then use potassium hydroxide solution to adjust the pH of the solution above 11.0, stir at high speed for 2 hours, filter the product, and wash with deionized water twice , washed twice with ethanol, dried at 50°C, and calcined at 800°C in air for 6 hours to obtain a dry product.

[0097] Take the product prepared above and place it in a citric acid-sodium hydroxide buffer solution with a pH of 6.0, stir continuously at 25°C for 6 hours, centrifuge the product, remove the supernatant, was...

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Abstract

The invention provides a biodegradable mesoporous nano magnetic material and a preparation method thereof. The present invention adopts the in-situ co-precipitation method, dissolves a certain amount of salt containing calcium, phosphate and carbonate in the aqueous solution, stirs at a constant temperature at a certain temperature, then adds a certain amount of soluble iron, cobalt, nickel and other salts, and continues the constant temperature Stir for 10s-120h, filter the product, wash with ethanol twice, dry in the air and then calcinate at 600-1200°C for 2-12h, place the product in a citric acid-sodium hydroxide buffer solution with a pH of 4.5-7.4, and continuously Stir for 30min-24h, wash the product twice with deionized water and twice with ethanol, and dry at 50-60°C to obtain a nano-mesoporous magnetic material containing nano-magnetic materials in the skeleton. The mesoporous nano-magnetic material synthesized by the method of the present invention can be used as a magnetic targeting material for directional killing of tumors and cancer tissues, and has biodegradability, can be gradually degraded and discharged in a living body, and avoids the nanoparticle in a living body accumulation enrichment.

Description

technical field [0001] The invention belongs to the field of biological material preparation, and in particular relates to a biodegradable mesoporous nano magnetic material and a preparation method thereof. Background technique [0002] The traditional methods of treating cancer are radiotherapy (radiotherapy) and chemotherapy (chemotherapy). The biggest difficulty is that it is difficult to ensure the regeneration and function of normal cells and tissues while killing tumor cells, and there is no specificity in treatment. In the 1970s, Widder et al. proposed the concept of a magnetically controlled targeted drug delivery system. At present, magnetic nanoparticle anticancer therapy has become a key direction in the research of targeted and controlled release systems for anticancer drugs at home and abroad. For magnetic drug targeted therapy, a variety of carrier materials such as magnetic albumin, magnetic liposome, and magnetic medical polymer materials have been developed....

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/00A61P35/00B82Y5/00B82Y25/00H01F1/01C12M1/42
CPCA61K9/0009A61K41/00A61P35/00B82Y5/00B82Y25/00C12M1/42H01F1/01
Inventor 王璞琳马铭
Owner DONGGUAN UNIV OF TECH
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