71 results about "Hematology analyzers" patented technology

A sampling and injection device for hematological analyzer comprises a loading means for holding cassettes (3) of tubes with blood samples, a mixing means (5) for mixing the blood samples in the tubes, a dragging means (4) for transferring the tubes stored in the sampling and injection device to the mixing means (5), a piercing means (6) for analyzing the blood components, and an unloading means (7) for unloading the cassettes (3). Each of these means cooperates with each other to realize the blood samples to be sampled and injected automatically.

The invention relates to the technical field of human body blood detection apparatuses, and discloses a 5-part differential hematology analyzer optical system. The 5-part differential hematology analyzer optical system comprises a front light shaping assembly, a sample shaping assembly and a diffusion light receiving assembly. The front light shaping assembly is characterized by arranging a laser, a collimating lens, a fast axis focusing lens and a slow axis focusing lens in an optical path, and the fast axis focusing lens and the slow axis focusing lens are fixed in a shaping lens barrel capable of rotating for 360DEG; and the diffusion light receiving assembly is characterized in that three annular light through holes are arranged on a diaphragm to form a low angle scattered light transmission area, a medium low angle scattered light transmission area and a medium high scattered light transmission area, a photoelectric detection array corresponding to the three annular light through holes is provided with a low angle lighting electric detector, a medium low angle lighting electric detector and a medium high lighting electric detector, and the detectors respectively output electric signals. The diffusion light reception of the optical system is realized by directly acquiring leucocyte diffusion light signals in three different areas in an approaching 360DEG range, and the integrated photoelectric detector array is adopted, so the optical system has the advantages of simple optical path structure, low cost, use convenience, stable signal source and high accuracy.

The invention provides benzpyrole squaric acid cyanine dye. The general formula of the structure of the benzpyrole squaric acid cyanine dye is shown in the description, wherein X is one of Br, Cl and I, and R is one of the following structures shown in the description. The benzpyrole squaric acid cyanine dye provided by the invention has good stability and large absorption strength, can be applied in matching reagents of a 5-classified hematology analyzer to be used as dye of nucleated red blood cells, and can also be applied to fluorescent marks and other life science research fields.

The invention discloses a mixing device used for a hematology analyzer. The mixing device comprises a mounting rack, a first fixing base, a second fixing base, a motor, a pinion, a big gear, a fixing body, a supporting body and a sample fixing rack, wherein the first fixing base is arranged at one side of the mounting rack; a fixing body bearing is embedded into the first fixing base; a fixing body is mounted on the inner ring of the fixing body bearing; the big gear is arranged at one end of the fixing body in a sleeving mode; the pinion is arranged at one side of the big gear; one end of the pinion is connected with the motor; the sample fixing rack is mounted on the fixing body; one end of the sample fixing rack is mounted at one end of the supporting body; the supporting body is mounted in the supporting body bearing; the supporting body bearing is embedded into the second fixing base. The mixing device is compact in structure, wide in range of application of power and shake-up speed, capable of carrying out shake-up while mounting more than 10 samples once and improving the mixing efficiency, accurate in transmission ratio, high in transmission efficiency, capable of controlling a sample to swing by any angle, and capable of sufficiently shaking up.

The invention discloses a sheath flow device of a hematology analyzer. The sheath flow device comprises a sheath flow device seat, a sheath flow chamber and a sheath flow device cover, wherein the sheath flow chamber and the sheath flow device cover are arranged at two ends of the sheath flow device seat; a sample injection needle is arranged in an inner cavity of the sheath flow device seat through a needle seat; the sheath flow chamber comprises a sheath flow chamber body which is of a cube shape; a flow-in cavity, a flow-out cavity and a test cavity communicating the flow-in cavity with the flow-out cavity are formed in the sheath flow chamber body; the test cavity is 60-80 microns high, and the aperture of the test cavity is 50-100 microns; the geometric center of the test cavity is superposed with that of the sheath flow chamber body; the flow-in cavity and the flow-out cavity are symmetric to each other about a horizontal line which penetrates through the geometric center of the test cavity and serves as a symmetric shaft; the center axis of the flow-in cavity, the center axis of the flow-out cavity and the longitudinal center axis of the test cavity are superposed with the longitudinal center axis of the sheath flow chamber body. The sheath flow device disclosed by the invention can simultaneously acquire laser scattering test data and impedance test data of a single cell while being linked with a system.

A method to track stability and performance of diagnostic instrumentation, especially for veterinary automated hematology analyzers, applies a weighted moving averages algorithm to the diagnostic results of patient samples calculated by the analyzer. Control chart rules are used to set limits or ranges in order to determine if weighted averaged diagnostic results are within or outside of such limits or ranges. If the weighted average diagnostic results are outside of such control chart rule limits, then fuzzy logic and a gradient descent algorithm are applied to the weighted averaged diagnostic results.

The invention discloses a diluent for a hematology analyzer. The diluent for the hematology analyzer comprises sodium chloride, sodium sulfate, a phosphate buffer agent, ethylene diamine tetraacetic acid, 1-pyridone-2-sulphur and formaldehyde, and the pH value of the solution is 6.5-7.4, and preferably is 7.2; the content of each component is preferably as follows: 5g / L of sodium chloride, 10g / L of sodium sulfate, 0.3g / L of ethylene diamine tetraacetic acid, and 0.2ml / L of 1-pyridone-2-sulphur. The diluent for the hematology analyzer provided by the invention has the beneficial effects that general physical mixing can be adopted, and the preparation is extremely convenient; 1-pyridone-2-sulphur replaces the commonly used antimicrobial preservative sodium azide, is non-toxic, is safe to use, and can not cause harm or damage to reagent producers and environments; formaldehyde not only has a preservation effect, but also can keep the completeness of forms and structures of blood cells, and can increase the mechanical injury performance of the blood cells; and the diluent provided by the invention can achieve the testing effect equivalent to that of the original sheath fluid, and the cost is controlled well.

The invention discloses a preparation method of a quality control material / control substance for a urine visible component analyzer. The preparation method comprises the following steps: preparation of an erythrocyte simulant, preparation of a leukocyte simulant, preparation of a tubular cell simulant and preparation of the quality control material; independent or random combination of the several simulants to synthesize the required quality control material / control substance, wherein the obtained quality control material / control substance can be applied to the urine visible component analyzer or a hematology analyzer. According to the preparation method, by cell treatment and improvement on a treatment liquid formula, the prepared quality control material / control substance can make up for the shortcoming of lack of quality control materials in China.

A linearity control system includes a series of linearity control compositions; each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2x103 to 800x103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120x103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and / or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.

The invention discloses a reagent set for a five-classification hematology analyzer. The reagent set comprises a diluent, a hemolytic agent and a staining fluid. The reagent set for the five-classification hematology analyzer has the characteristics of reasonable formula, easily accessible raw material, easiness in processing, low cost and the like, and therefore, has a very good popularization value. The status quo that a regent for a hematology analyzer in China depends on import is changed. As the hemolytic agent-SLS in a reagent is a cyanide-free hemolytic agent, not only are harms to thebody health of personnel of production units and experiment operators greatly reduced, but also environmental pollution caused by a cyanide is avoided. The reagent is suitable for an XN-series five-classification full-automatic hematology analyzer of Sysmex Corporation in Japan, and correlation coefficients of the imported XN reagent and white blood cell, red blood cell, hemoglobin, blood platelet and the like are all more than 0.95.

Herein is provided a method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation and / or differentiation between red blood cells (RBCs) and white blood cells (WBCs) by utilizing a fluorescent dye to selectively stain WBCs such that they emit stronger fluorescence signals. The method provides optimal detection limits on WBCs and RBCs, thereby allowing analysis of samples with sparse cellular concentrations. As few as one reagent may be used to prepare a single dilution for body fluid analysis, in order to simplify the body fluid analysis. Minimal damage to WBCs is attained using the lysis-free approach described in aspects of the disclosure.

The invention provides a leukocyte classification counting method and device and a blood analyzer, and the method comprises the steps: obtaining an initial leukocyte histogram of leukocytes in a bloodsample, wherein the initial leukocyte histogram is a quantity and volume distribution histogram of leukocytes; defining a blood shadow area in the initial leukocyte histogram; and correcting the blood shadow region to obtain a corrected lymphocyte region. According to the leukocyte counting and classifying method, the leukocyte counting and classifying device and the blood analyzer provided by the embodiment of the invention, the interference of the blood shadow area to the lymphocyte area in the leukocyte histogram can be weakened and even eliminated, and the leukocyte counting and classifying accuracy is improved.

The invention discloses a blood drawing device for a hematology analyzer. The device relates to the medical field, and includes a first blood drawing tube, a first cover plate is arranged at the top of the first blood drawing tube; a dustproof sleeve is arranged in the middle of the top of the first cover plate; a reset spring is arranged in the dustproof sleeve, a pressing column is arranged at the top of the reset spring, a pressing plate is arranged at the top of the pressing column, a hose is arranged at the top of the pressing plate, a second blood feeding needle penetrating into the dustproof sleeve is fixed to the bottom of the hose, and a first cavity is formed in the bottom of the first blood drawing tube. The internal thread and the external thread are matched with each other; the second blood feeding needle is inserted into the first rubber sleeve at the bottom of the first blood drawing tube, meanwhile, the second cover plate is rotated to drive the connecting column to rotate into the first cavity, connection of multiple sets of blood drawing tubes is completed, sampling is facilitated, meanwhile, the phenomenon that the blood feeding needle is polluted is reduced, anduse safety is greatly improved.

The invention discloses a blood disease leukocyte scatter diagram similarity analysis method based on structural analysis, and belongs to the technical field of blood cell classification. The method comprises the following steps: extracting cell counting results and leukocyte scatter diagrams of various blood diseases detected by a hematology analyzer, carrying out artificial staining microscopicexamination to confirm the types of the blood diseases, carrying out classified storage according to the types of the blood diseases, and constructing a training set; comparing the leukocyte scatter diagrams of each category in the training set through a structural similarity analysis algorithm to obtain similarity; analyzing the similarity to obtain a characteristic leukocyte scatter diagram anda similarity range of each type of blood diseases, and taking the characteristic leukocyte scatter diagram as an original image; the to-be-detected image detected by the hematology analyzer is compared through the original image and the similarity range of each type of blood diseases, automatic classification of images collected by the hematology analyzer is achieved, and the effect of quickly andaccurately analyzing and classifying leukocyte scatter diagrams of the blood diseases is achieved.

A device for processing blood product samples contained in test tubes (18) closed with stoppers and loaded in boxes (12), comprising transport means (10) for moving the boxes one by one on a predetermined path; A shaking device (30) with at least one picking device (32) that can be activated by a drive device (88) to pick at least one selected test tube from a box that is stationary on the path, so that The test tube is moved away from the box, the test tube is shaken and the test tube is returned to the box; and a sampling device (34) is capable of extracting a given amount of sample from the pre-shaken test tube that has been returned to the box. The device is used in hematology analyzers.

The invention discloses a medical waste liquid disinfecting device for a laboratory department. The medical waste liquid disinfecting device for the laboratory department comprises a bottom base. Thebottom base is internally provided with a foundation bolt. The foundation bolt is fixedly installed in the ground. A support plate is installed above the bottom base. A workbench is installed above the support plate. The right side of the support plate is provided with a storage device. A separating plate is installed above the workbench. The separating plate is fixedly connected with the side surface of the workbench. A hematology analyzer is installed above the workbench. The right side of the hematology analyzer is provided with a urine analyzer. The right side of the urine analyzer is provided with a centrifugal machine. The right side of the centrifugal machine is provided with an optical microscope. A test tube placing device is installed in front of the right side of the optical microscope. A minitype electronic scale is installed behind the test tube placing device. The right side of the minitype electronic scale is provided with a cleaning disinfecting device. The beneficial effect of the medical waste liquid disinfecting device is that the structure is simple and the practicability is strong.

The fluid circuit for a hematology analyzer includes a block-like plastic member with passageways for fluid, and a reaction chamber recess that communicates with one or more of the fluid passageways. A detachable metallic heat transfer cover member is positioned across the reaction chamber recess to close the reaction chamber recess and establish a confined reaction chamber. A heater is placed in conductive contact with the metallic heat transfer cover member to heat the cover member and thereby conduct heat to the reaction chamber. The metallic heat transfer cover member is detachably secured to the block-like plastic member and can thus be removed and replaced as needed.

The invention provides a POCT hematology analyzer and a detection method. The POCT hematology analyzer comprises a shell, a detection base, a pipettor and a movement mechanism; the detection base is arranged in the shell, is used for receiving a kit and is provided with a plurality of impedance detection assemblies and / or a plurality of optical detection assemblies, and each impedance detection assembly comprises an electrode conductive device; the kit is provided with a detection device, the electrode conductive device is electrically contacted with the detection device when the kit is arranged in the detection base, and the optical detection assembly comprises a light emitting assembly and a light receiving assembly which are arranged at an interval; the pipettor is arranged in the shell and is used for carrying out pipetting operation on the kit; the movement mechanism is arranged in the shell and is used for enabling the pipettor to move relative to the detection base so as to support the pipetting operation. Through the cooperation of the movement mechanism and the pipettor, the automatic blood sample distribution and the automatic reagent addition can be achieved; the detection base is provided with the plurality of impedance detection assemblies and / or the plurality of optical detection assemblies, so that detection items can be increased, and the POCT detection efficiency is optimized.

The disclosed feeding sample device for a biochemical analyzer comprises: a feeding sample needle (3), a rocker (2), a drive system, a control system; an anti-bump sensing device with a fixing base (1), a universal joint (4), a spring (5), a sleeve (6), a anti-light sheet (7) and a sensor (8); a liquid-level detection and alarm device, a detection and alarm device for needle block, and a display device with a lamp shield (9), a guide bar (10), an anti-bump detection signal light (11), a signal lamp for needle-block (12), and a detection lamp for liquid level(13). This invention has wide application.

The invention provides a liquid flow driving device for a POCT hematology analyzer and an impedance detection cell. The driving device comprises a pressure source; the impedance detection cell comprises a front cell and a rear cell which are communicated through a micropore, and a detection electrode used for cooperatively carrying out impedance detection; the pressure source is used for applying pressure to the front cell, so that liquid in the front cell flows to the rear cell through the micropore. By applying pressure to the front cell, liquid in the front cell flows to the rear cell through the micropore, so that an additional negative pressure generation device is not needed; and the pressure source can reuse a pipettor in the POCT hematology analyzer, so that the product assembly structure can be simplified, and the cost can be reduced.

The invention discloses a multichannel trace quantification system of a hematology analyzer, which comprises a ceramic blood dividing valve front cover, a ceramic flow dividing sheet, a ceramic blooddividing valve rear cover, a rotary valve sheet mechanism and a five-channel trace quantitative blood dividing valve, the ceramic blood dividing valve front cover is rotationally connected with the ceramic flow dividing sheet; the ceramic blood dividing valve rear cover is rotationally connected with the ceramic flow dividing sheet; the valve core is positioned on one side far away from the ceramic blood distribution valve front cover; the rotary valve plate mechanism is fixedly connected with the ceramic blood distribution valve front cover; the five-channel trace quantitative blood distribution valve is fixedly connected with the ceramic blood distribution valve front cover, the ceramic flow distribution sheet and the ceramic blood distribution valve rear cover; the five-channel micro quantitative blood distribution valve comprises a ceramic blood distribution valve front cover, a ceramic flow distribution part and a ceramic blood distribution valve rear cover, the five-channel microquantitative blood distribution valve comprises five different channels which are arranged in a circular array mode, the number of detection types is increased, and the detection time is shortened.

The invention provides a liquid path system which comprises a liquid path of a pretreatment module, a liquid path of a reagent 1 input module, a liquid path of a reagent 2 input module, a liquid pathof a reagent 3 input module and a liquid path of a detection device cleaning module, wherein pipelines for detecting and analyzing lymphocytes, mononuclear cells, neutrophils, eosinophils and basophils are the same pipeline, the liquid path system is simplified, later installation and maintenance are facilitated, a solvent preheating device is added into the liquid path system, the reaction between reagents and samples can be accelerated, meanwhile, the invention also provides a hematology analyzer comprising the liquid path system, and the hematology analyzer is small in size.

The subject invention pertains to methods and systems for classifying leukocytes using artificial intelligence called AIRFIHA (artificial-intelligence enabled reagent-free imaging hematology analyzer) that can accurately classify subpopulations of leukocytes in a label-free manner. AIRFIHA can not only subtype lymphocytes into B and T cell but is capable of sorting different types of T cells subtypes. AIRFIHA is realized through training a two-step neural network using label-free images of separated leukocytes acquired from a custom-built quantitative phase microscope. Owing to its easy operation, low cost, and strong discerning capability of complex leukocyte subpopulations, AIRFIHA is clinically translatable and can also be deployed in resource-limited settings.

The invention discloses a hematology analyzer and a hematology analysis method. The hematology analyzer comprises a blood sample collection device, a reagent supply device, a blood sample reaction device and a blood sample detection device. The blood sample collection device is used for collecting and providing a to-be-detected blood sample. The reagent supply device is used for providing a reagent used for analyzing the to-be-detected blood sample. The blood sample reaction device is used for receiving the to-be-detected blood sample provided by the blood sample collection device and the reagent provided by the reagent supply device, mixing and reacting to obtain a reacted to-be-detected blood sample. The blood sample detection device is used for receiving the reacted to-be-detected bloodsample and carrying out blood cell analysis and blood type detection on the reacted to-be-detected blood sample so as to obtain blood routine parameters and a blood type detection result of the to-be-detected blood sample. By means of the mode, blood routine examination and blood type detection can be achieved on the hematology analyzer at the same time, and pain of a patient is relieved.