The invention provides an epinephelus fuscoguttatus and epinephelus tukula hybrid artificial breeding method. The method includes: carrying out staged feeding in an indoor pond with water depth of 1-2m; in a first stage, releasing newly hatched fry of epinephelus fuscoguttatus and epinephelus tukula hybrid into the pond, and feeding with 50-100micron powdery feed A from the first day to the ninthday, wherein the powdery feed A is prepared from soybean meal, squid paste, coconut oil, mannan oligosaccharide, antibacterial peptides, malic acid and astaxanthin, and the daily feeding amount is 10-15% of the fish weight; in a second stage, feeding with 80-200micron powdery feed B from the tenth day to the twenty-fourth day, wherein the powdery feed B is prepared from soybean meal, corn flour, ginger powder, coconut powder, brown sugar, herba paederiae leaf powder, ground pepper, taurine and lactic acid bacteria, and the daily feeding amount is 15-20% of the fish weight; in a third stage, feeding with granular feed C from the twenty-fifth day to the fortieth day, wherein the granular feed C is prepared from corn flour, peanut meal, artemia powder, compound algae powder, rhizoma calami grass meal, folium musae powder and herba paederiae leaf powder, and the daily feeding amount is 20-25% of the fish weight. By adoption of the method, high survival rate in breeding is realized, and obtained epinephelus fry are large in size.