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91 results about "Enhancing Antibodies" patented technology

Signal enhancing antibodies increase the overall size of the antigen-antibody complex and results in increased signal strength and assay sensitivity. An antibody bridging event occurs when an antibody is recognized by a second labeled antibody thereby presenting an additional detection mechanism.

Methods for enhancing antibody-induced cell lysis and treating cancer

The invention relates to methods and products for treating cancer. In particular the invention relates to combinations of nucleic acids and antibodies for the treatment and prevention of cancer. The invention also relates to diagnostic methods for screening cancer cells.
Owner:IOWA RES FOUND UNIV OF +1

Compositions and methods relating to universal glycoforms for enhanced antibody efficacy

The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(α2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds FcγRIIA or FcγRIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
Owner:ACAD SINIC

Ganglioside-KLH conjugate vaccines plus QS-21

This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject, an effective amount of adjuvant and a pharmaceutically acceptable vehicle.
Owner:SLOAN KETTERING INST FOR CANCER RES

Antibodies and conjugates thereof

Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof. Some embodiments of the antibodies can be conjugated to a moiety, such as a HEMA-PC polymer. Some embodiments of the antibody conjugates can retain or enhance antibody activity. The antibody and conjugate thereof can be particularly useful for treating diabetic retinopathy. Further provided are methods for conjugation of a polymer to a protein such as an antibody, such as IgG1.
Owner:KODIAK SCI

Apparatus and method for non-contact microfluidic sample manipulation

An electro-hydrodynamic apparatus and method of using the same is disclosed. The electro-hydrodynamic apparatus includes a liquid sample supported on a substrate, with at least one electrode located proximate the surface of the liquid sample without contacting the liquid sample. A power supply creates an electric field proximate the surface of the liquid sample, thereby inducing a motion to the liquid sample. The apparatus may be used for focusing and separating particles within a liquid, and pumping and mixing a liquid sample or a liquid mixture with or without particles. The apparatus creates a primary rotational flow on a liquid surface to create a secondary inertial flow. The apparatus may be used to focus particles and / or pathogens to increase the sensitivity of current detection techniques and to enhance immuno-sensing techniques, as well as to mix heterogeneous components of a liquid sample by acting as a stirring without mechanical moving parts and to enhance antibody-antigen interactions, to pump liquids in lab-on-a-chip, clinical and environmental diagnostic kits, or to separate particles and / or pathogens by utilizing different dielectrophoretic mobilities, magnetic susceptibilities and / or antibody affinities.
Owner:NOTRE DAME DU LAC UNIV OF THE

Air-conditioning mattress

The invention relates to the field of mattresses in articles for daily use, in particular to an air-conditioning mattress. The air-conditioning mattress consists of an elastic body, and comprises a head part, a body part and a foot part, wherein the head part and the foot part consist of sponge bodies; the body part consists of an elastic cushion which comprises an air bag cushion layer and a bottom layer; the air bag cushion layer and the bottom layer have corresponding sizes, and the peripheries of the air bag cushion layer and the bottom layer are adhered together; an air supply pipe is arranged between the air bag cushion layer and the bottom layer; a plurality of air supply holes are uniformly formed on the air supply pipe; air outlet holes are formed among air bags of the air bag cushion layer; and gaps among the air bags of the air bag cushion layer form air supply passages. The mattress can supply cold and war air to ensure that a whole body feel comfortable, and the oxygen and the humidity of the body cannot volatilize when the mattress is used for a long time; besides, the mattress has the characteristics of fresh-keeping, deodorization and sterilization, can promote blood circulation, enhance antibodies, alleviate aching pains, and regulate blood pressure and autonomic nerves to achieve effects of beautification and the like, and has a physical therapeutic effect on various chronic diseases when used for a long time.
Owner:洪志强
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