The invention discloses compound
florfenicol injection and a preparation method thereof. The compound
florfenicol injection comprises the following components: 500g of
florfenicol, 500g of
doxycycline hyclate, 500g of
tilmicosin phosphate, 3,000g of
polyvinylpyrrolidone, 4,000g of N, N-dimethylacetylamide, 200g of
magnesium chloride, 20g of
sodium formaldehyde sulphoxylate and 10,000 milliliters of water for injection. The preparation method comprises the following steps of: (1) preparing; (2) adding
doxycycline into the
polyvinylpyrrolidone, heating to 80 DEG C, stirring until a mixture is clarified, adding the
tilmicosin phosphate, and stirring until a mixture is clarified; (3) heating dimethylacetylamide to 50 DEG C, adding the florfenicol, and stirring for dissolving; (4) adding 1,000 milliliters of water for injection, adding the
magnesium chloride and the
sodium formaldehyde sulphoxylate in turn, and stirring for dissolving; and (5) mixing solution prepared in the step (2) and the step (3), gradually adding solution prepared in the step (4) under stirring, replenishing the water for injection until the total volume of the water for injection is 10,000 milliliters, uniformly stirring, filtering, filling
nitrogen, encapsulating, and sterilizing at the temperature of between 110 and 115 DEG C for 30 minutes to prepare the compound florfenicol injection.