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Doxycycline hyclate enteric-coated pellet

A technology of doxycycline hydrochloride and enteric-coated pellets, applied in the direction of tetracycline active ingredients, microcapsules, anti-infectives, etc. Blood concentration, stable absorption effect

Active Publication Date: 2011-08-17
Yung Shin Pharm Ind (Kunshan) Co Ltd
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Can not achieve the purpose of rapid onset of antibiotics

Method used

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  • Doxycycline hyclate enteric-coated pellet
  • Doxycycline hyclate enteric-coated pellet
  • Doxycycline hyclate enteric-coated pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A. Raw materials for enteric-coated pellet preparations

[0052] Doxycycline Hydrochloride 100g

[0053] Blank ball core 160g

[0054] Polyvinylpyrrolidone K30 8g

[0055] Purified water 94g

[0056] Ethanol 25g

[0057] HPMCP-50 10g

[0058] Glycerin acetate 2g

[0059] Acetone 95g

[0060] B. Method for preparing enteric-coated pellet preparation

[0061] Dissolve polyvinylpyrrolidone K30 in purified water and ethanol to make a binding agent; pulverize doxycycline hydrochloride for later use; put the blank ball core into the coating pan, and spray the binding agent; then add crushed hydrochloric acid For doxycycline, repeat the operation until it is completed; dry for 3 to 4 hours to completely evaporate the water and form drug-coated pellets.

[0062] Add HPMCP-50 and acetic acid glycerin to acetone and stir until dissolved to form an enteric coating solution; put the drug-coated pellets into the coating pan, spray the enteric coating solution at room temperatu...

Embodiment 2

[0065] A. Enteric-coated pellet preparation

[0066] Doxycycline Hydrochloride 100g

[0067] Blank ball core 156g

[0068] Polyvinylpyrrolidone K30 8g

[0069] Purified water 94g

[0070] Ethanol 25g

[0071] HPMCP-50 14g

[0072] Glycerin acetate 2g

[0073] Acetone 95g

[0074] B. Method for preparing enteric-coated pellet preparation

[0075] Dissolve polyvinylpyrrolidone K30 in purified water and ethanol to make a binding agent; crush doxycycline hydrochloride for later use; put the blank ball core into the coating pan, spray the binding agent, and then add crushed hydrochloric acid For doxycycline, repeat the operation until it is completed; dry for 3 to 4 hours to completely evaporate the water and form drug-coated pellets.

[0076] Add HPMCP-50 and acetic acid glycerin to acetone and stir until dissolved to form an enteric coating solution; put the drug-coated pellets into the coating pan, spray the enteric coating solution at room temperature, and repeat the op...

Embodiment 3

[0079] A. Enteric-coated pellet preparation

[0080] Doxycycline Hydrochloride 100g

[0081] Blank ball core 137g

[0082] Polyvinylpyrrolidone K30 7g

[0083] Purified water 85g

[0084] Ethanol 20g

[0085] HPMCP-50 30g

[0086] Glycerin acetate 6g

[0087] Acetone 254g

[0088] B. Method for preparing enteric-coated pellet preparation

[0089] Dissolve polyvinylpyrrolidone K30 in purified water and ethanol to make a binding agent; crush doxycycline hydrochloride for later use; put the blank ball core into the coating pan, spray the binding agent, and then add crushed hydrochloric acid For doxycycline, repeat the operation until it is completed; dry for 3 to 4 hours to completely evaporate the water and form drug-coated pellets.

[0090] Add HPMCP-50 and acetic acid glycerin to acetone and stir until dissolved to form an enteric coating solution; put the drug-coated pellets into the coating pan, spray the enteric coating solution at room temperature, and repeat the o...

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Abstract

The invention discloses a doxycycline hyclate enteric-coated pellet which comprises the following components in percentage by weight from inside to outside: 48-58 blank core pellet, 35-40 medicinal layer and 4-13 enteric-coated layer. The invention also discloses a method for preparing the doxycycline hyclate enteric-coated pellet. The doxycycline hyclate enteric-coated pellets prepared by the method are filled into a capsule, and an obtained enteric-coated preparation has the advantages of increased contact area with the intestinal tract, high bioavailability, good stability, steady release in vitro and vivo, no influence by gastrointestinal peristalsis and food intake, uniform absorption, smaller difference of bioavailability among individuals, and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular, the invention relates to doxycycline hydrochloride enteric-coated pellets. Background technique [0002] Doxycycline has a wide range of clinical applications. At present, doxycycline hydrochloride is mostly used. In addition to the treatment of upper respiratory tract infection, lymphadenitis, tonsillitis, senile chronic bronchitis, and biliary tract infection, this product is also An important drug for the treatment of genitourinary tract infections and acne. However, since doxycycline hydrochloride is often irritated to the gastrointestinal tract, patients often experience symptoms such as nausea and vomiting after taking it, which greatly reduces the curative effect. Therefore, after doxycycline hydrochloride is made into an enteric-coated preparation, its curative effect can be improved. [0003] Pellets refer to small spherical oral preparations with a diameter of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/50A61K31/65A61P31/00
Inventor 李芳全苏龙吴保祥
Owner Yung Shin Pharm Ind (Kunshan) Co Ltd
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