Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Kurarinone formulation and its preparation process

A technology of matrine and sustained-release preparations, applied in the field of matrine preparations and its preparation, which can solve the problems of poor compliance, long course of treatment for chronic hepatitis, difficulty for patients to adhere to long-term treatment, etc.

Inactive Publication Date: 2006-02-08
山东益康药业股份有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The human pharmacokinetic study of matrine shows that the half-life is (130.4±43.7) minutes. It is a fast-disposing drug. After injection, the half-life is about 12 hours and it is basically completely cleared from the body. It is difficult to inject once a day. Maintain effective therapeutic effect; moreover, chronic hepatitis has a long course of treatment, long-term injection administration, especially intramuscular injection, local irritation, redness, swelling and pain are obvious, patients are difficult to adhere to long-term treatment, and compliance is poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Kurarinone formulation and its preparation process
  • Kurarinone formulation and its preparation process
  • Kurarinone formulation and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take the raw materials according to the following weight ratio:

[0050] Matrine 400 parts

[0051] Hypromellose 300 parts

[0052] 90% ethanol solution 100 parts

[0053]Lactose 25 parts

[0054] Magnesium Stearate 8 parts

[0055] The production method is as follows:

[0056] Such as figure 1 As shown, matrine, hypromellose, lactose, and magnesium stearate were crushed separately, and passed through a 100-mesh sieve for later use; according to the above weight ratio, matrine and hypromellose were fully mixed, passed through 100 Mesh sieve; add 90% ethanol solution of above-mentioned weight ratio to make soft material in matrine and hypromellose after sieving; make wet granule to soft material through 20 mesh sieves; wet granule in 55 Dry at ±2°C; pass the dried granules through a 18-mesh sieve for granulation; add the above-mentioned weight ratio of magnesium stearate and lactose to the sized raw materials for mixing; measure the granules of the mixed raw materi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an oxymatrine preparation for treating hepatitis B, which is prepared from oxymatrine, methyl hydroxypropylcellulose, lactose and magnesium stearate through the steps of disintegrating, sieving, mixing, making wet particles, drying, sieving and charging magnesium stearate and lactose, finally mixing and tabletting.

Description

technical field [0001] The invention relates to a medicine for treating hepatitis B, in particular to a matrine preparation and a preparation method thereof. Background technique [0002] Matrine is an effective liver-protecting and anti-viral drug extracted from the Chinese herbal medicine Sophora flavescens and Sophora flavescens root with high-tech technology after more than 20 years of research in scientific and technological research in my country. The hepatitis treatment drug was designated as a key promotion project by the Chinese Medical Association in 1998. At present, the matrine preparations clinically used for the treatment of chronic hepatitis B and chronic hepatitis C include: ① matrine injection solution, the specification is 200 mg / ml, the dosage is 400 mg / day, or 600 mg / day, administered intramuscularly once a day, and the course of treatment is 60-90 days; ② Kushensu Glucose Injection, the specification is 600 mg / ml , the dosage is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4375A61K9/22A61P1/16A61P31/14
Inventor 高敬方邓树海高肇林魏伟满其永
Owner 山东益康药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com