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Doxycycline hyclate liposome and production thereof

A doxycycline hydrochloride and liposome technology, which is applied in liposome delivery, tetracycline active ingredients, pharmaceutical formulations, etc., can solve the problems of increasing drug loading, prolong the action time, enhance the antibacterial effect, and prevent loss Effect

Inactive Publication Date: 2010-09-08
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the local action time and effect of specific drugs are related to the preparation method of liposomes and the components of liposomes; and for different drug active ingredients, especially for doxycycline hydrochloride water-soluble drugs, the lipid The encapsulation efficiency of the body, increasing the drug loading is also a problem

Method used

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  • Doxycycline hyclate liposome and production thereof
  • Doxycycline hyclate liposome and production thereof
  • Doxycycline hyclate liposome and production thereof

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Embodiment 3

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Abstract

A doxycycline hydrochloride liposome with high optical and thermal stability, high power to pass through skin and mucosa, and high antibacterial effect is prepared from phosphatide, cholesterol, doxycycline hydrochloride and emulsifier by film dispersing method, injection method, or reverse evaporation method.

Description

technical field The invention relates to a doxycycline hydrochloride liposome and a preparation method thereof. Background technique Doxycycline hydrochloride (doxycycline hydrochloride, doxycycline hydrochloride) is a tetracycline antibiotic. It can be widely used in respiratory, urinary, reproductive system and biliary tract infections, and has certain curative effects on skin and soft tissue infections, sepsis, acne, brucellosis, trachoma, gonorrhea, etc., and can effectively control subgingival plaque in periodontal pockets, Inhibit periodontal disease pathogenic bacteria. But the current doxycycline hydrochloride crude drug is unstable to light and heat, and is not easy to store. And doxycycline hydrochloride preparation mainly contains tablet and capsule at present, because the water solubility of doxycycline hydrochloride is better prepared into topical preparation, then the permeability to skin, mucous membrane is poor, local drug action time and antibacterial effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K9/127A61K47/24A61K47/22A61P31/04
Inventor 芦洁金鸿莱胡纯贞奉建芳肖忠革
Owner SHANGHAI INST OF PHARMA IND CO LTD
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