53 results about "Creatine Monohydrate" patented technology

The present invention provides methods of treating neurological disorders, such as Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis, by administering creatine monohydrate and dextrose, alone or in combination with an anti-inflammatory compound, to a subject.

The present invention relates to the use of creatine compounds, such as, for example, creatine monohydrate, creatine pyruvate and creatine ascorbate, for the treatment of skin.

The feed additive is characterized by that said feed additive is a mixture of pyruvate and creatine monohydrate, in which the content of pyruvate is 55-75 wt%. The can raise thin-meat rate in animal body obvious, and has no harmful substance, is safe for human body.

The invention discloses a novel fattened pig compound feed and a preparation method thereof. The novel fattened pig compound feed is prepared from the following raw materials in percentage by weight: 35-50 percent of corns, 20-35 percent of puffed peas, 15-40 percent of wheat and 3-4 percent of a premix. According to the digestion physiological characteristic of a fattened pig, the peas, the corns and the wheat, which are high in biological utilization rate, are used as basic feed materials, and synthesized creatine monohydrate is creatively mixed with glucose, D-pinitol and other additives to replace conventional fish meal, so that under a condition of reducing the feeding cost, the lean rate is increased, the growth speed is increased, the digestion absorption rate is improved, and the resistance to pathogens is enhanced; nitrogen emission is alleviated, and the feeding environment is improved. Meanwhile, an advanced puffing technology is adopted, so that the puffing efficiency and the fat digestion rate as well as the palatability of the feed are improved. The novel fattened pig compound feed has the characteristics of high lean rate, stable quality, low cost, high fat digestion rate, high palatability, low excrement pollution and the like and has a high popularization value.

The invention provides a tin alloy electroplating solution. The tin alloy electroplating solution comprises organic mixed acid, organic tin salt, organic metal salt, complexing agents, reducing agents, stabilizing agents, refining agents, brightening agents and deionized water. The tin alloy electroplating solution comprises, by weight, 1000 parts of deionized water, 100-600 parts of organic mixedacid, 40-100 parts of organic tin salt, 1-8 parts of organic metal salt, 50-160 parts of complexing agents, 30-70 parts of reducing agents, 20-100 parts of stabilizing agents, 5-20 parts of refiningagents and 3-15 parts of brightening agents. The organic metal salt comprises one of organic silver salt, organic copper salt and organic bismuth salt. The complexing agents comprise one or more of thiourea, 1,3-dimethylthiourea, 2,4-dithiobiuret, 2,4,6-trithio-triuret, 2,2-dithiodipyridine, 2,2-dithio-aniline, tetramethyl guanidine, guanidinoacetic acid, creatine monohydrate and sulphydryl chitosan.

The invention provides a ribose functional food. The ribose functional food comprises the following components in parts by weight: 30-70 parts of the D-ribose, 10-60 parts of the L-propionylcarnitine, 0.02-10 parts of the L-malic acid, 0.17-0.5 parts of the coenzyme Q10 and 5-20 parts of the maltodextrin which are taken as main raw materials; one or more of magnesium gluconate, calcium gluconate, selenomethionine, taurine, creatine monohydrate, NADH (NicotinamideAdenine Dinucleotide), glutamine, glycine, spices and edible pigments are selected as auxiliary materials to be mixed to prepare oral preparations including tablets, capsules, granules and oral solutions. The invention provides the functional food capable of increasing the energy in the body, accelerating the recovery of fatigue, increasing the myocardium energy, reducing the oxygen consumption amount and accelerating the recovery of an organism aiming at people who are occupied in high-strength physical exercise or heavy physical labor, coronary heart disease prognostic patients, old people and patients of some chronic diseases.

Belonging to the technical field of pig feed additives, the invention provides a novel additive special for big pigs. The additive is composed of the following components by weight: 40-60% of creatine monohydrate, 1-2% of vitamin E, 1-1.5% of organic rare earth, 1-3% of cysteine hydrochloride, 2-4% of a perilla seed extract, and the balance corn cob powder. According to the invention, creatine monohydrate, vitamin E, organic rare earth, cysteine hydrochloride, the perilla seed extract, and corn cob powder are compounded together according to certain proportion, so that all the components can supplement each other, and the feed additive can reach the efficacy of promoting big pig growth, improving the immunity of big pigs, enhancing the lean meat rate, and improving the meat quality.

The invention discloses a preparation method for creatine nitrate. The preparation method comprises the following steps: adding water and creatine monohydrate into a reaction container, and stirring and mixing at a temperature lower than 20 DEG C; then, adding nitric acid into the reaction container and controlling the reaction temperature to be lower than 40 DEG C, filtering reaction liquor after the reaction liquor is clarified, cooling the filtered reaction liquor to be lower than 5 DEG C within 0.5-1.5 hours under stirring, standing for 0.5-1.5 hours, centrifuging to separate out mother liquor and creatine nitrate wet crystals; drying the creatine nitrate wet crystals for 5-7 hours under reduced pressure at a temperature lower than 55 DEG C to obtain the creatine nitrate, and replacing mother liquor with water as raw materials for producing next batch of the creatine nitrate. According to the preparation method disclosed by the invention, the creatine nitrate with purity of 99.8% and creatinine lower than 30PPM and without creatine dinitrate and trinitrate can be obtained without re-crystallization, the yield of the creatine nitrate is higher than 83.8%, the energy consumption is reduced, and the cost is low. The whole preparation process is environmentally friendly.

The invention provides a function enhancer suitable for strenuous and speed-type physical activities and a preparation method thereof. The function enhancer is prepared from the following effective components: beta-alanine, L-arginine-alpha-ketoglutarate, creatine monohydrate, creatine citrate, L-citrulline-L-malic acid, zoysia tenuifolia seed extract, L-tyrosine, leucine, caffeine, taurine, olive leaf extract, black pepper extract, black carrot powder, vitamin complex and composite electrolyte. The function enhancer is prepared by a mixing mode. The function enhancer can enhance strength and explosive force in the process of physical activities, maximally stimulate the organism metabolism and relieve the feeling of fatigue, and ensure the organism reinforcing effect in training at the day after or in a competition state; and the preparation method of the function enhancer is simple and suitable for the requirement of large-scale industrial production.

Compositions for neuroprotection and treatment of neurodegeneration and methods of administering same. In particular, the present invention relates to compositions and methods for preventing or reducing neurodegeneration, such as neurodegeneration caused by Huntington's disease, including administering a daily dose of a composition including an effective amount of creatine hydrochloride to a patient in need thereof. The methods of the present invention allow for lower dosages of supplementation as compared to creatine monohydrate while retaining all of the desired biological effects of creatine supplementation.

The present invention relates to the use of creatine compounds, such as, for example, creatine monohydrate, creatine pyruvate and creatine ascorbate, for the treatment of skin.

The invention relates to a feed additive for enhancing immunity of yellow catfish, which is prepared from, by weight, 5-8 parts of L-lysine, 1-3 parts of magnesium acetate, 1-3 parts of organic selenium, 1-3 parts of trehalose, 2-5 parts of taurine, 5-8 parts of calcium pantothenate, 8-12 parts of creatine monohydrate, 5-8 parts of L-citrulline, 3-6 parts of sodium propionate, 2-5 parts of zinc gluconate, 5-8 parts of calcium hydrophosphate, 3-6 parts of calcium glycinate, 3-6 parts of pyridoxamine, 2-5 parts of folic acid, 2-5 parts of choline chloride, 5-8 parts of betaine, 2-4 parts of dimethyl-beta-propiothetin, 2-5 parts of sodium chloride, 2-5 parts of inositol, 1-3 parts of vitamin A, 1-3 parts of vitamin B, 5-8 parts of vitamin C, and 2-5 parts of vitamin E. The feed additive can effectively improve the diseases prevention and resistance effect of the yellow catfish and can enhance immunity.

The invention discloses a hatching method for increasing energy reserve of commercial generation hatching eggs of white feather broilers. In a later hatching stage of the commercial generation hatching eggs of the white feather broilers, 0.4 mL of sterilizing injection nutritive liquid is injected to embryo eggs, then hatching continues to be carried out under original hatching conditions for 21 days, and then the broilers are hatched, wherein each mL of the sterilizing injection nutritive liquid is prepared from 60-62.5 mg glucose and 10-15 mg creatine monohydrate. Compared with traditional hatching, by means of the technology, the energy matter reserve mainly including hepatic glycogen in the liver and the energy matter reserve mainly including creatine and phosphocreatine in the chest muscle in the later broiler embryo hatching stage are significantly increased and can last to the time when the broilers are one day old, the growing speed of the broilers in the early hatching-out period can be increased, and the breeding production efficiency of the broilers can be improved. The hatching method has the advantages of being low in cost, easy and convenient to implement, practical, high in operability and the like, and is suitable for being applied to poultry hatching production.

The invention discloses natural functional beverage composition capable of improving efficiency during movement training and application of the natural functional beverage composition. The natural functional beverage composition comprises the following components in parts by weight: 300-650 parts of soybean and potato isolated protein, 50-150 parts of branched chain amino acids, 300-650 parts of black kernelled rice and black kernelled rice starch, 60-200 parts of a beetroot extract, 50-150 parts of an agave extract, 1-20 parts of a rhodiola root extract, 10-50 parts of an organic apple skin extract, 50-150 parts of creatine monohydrate, 20-80 parts of taurine, 10-70 parts of coconut milk freeze-dried powder, 1-10 parts of a beet leaf extract, 0.1-2 parts of vitamin B1, 1-12 parts of magnesium aminosuccinate, 20-80 parts of natural spices containing soybean lecithin, 1-8 parts of sodium chloride, and 0.1-2 parts of potassium chloride. The composition can improve the antioxidation level and the aerobic metabolism level of organisms, improves the oxygen utilization efficiency of cells, and contributes to rapid improvement of movement performance and the efficiency of organisms.

The invention discloses a preparation method of guanidine derivative creatine hydrochloride, belonging to the technical field of additives. The method adopts a key technology of 'enabling materials to be recyclable and reusable without three wastes by strictly controlling moderate reaction temperature and corresponding conditions'; creatine monohydrate is taken as a material and thionyl chloride is adopted for acidolysis; the creatine monohydrate and the thionyl chloride are subjected to acidolysis salification; filtrate solution after filtering the acidolysis-salified acidolysis solution is subjected to vacuum reduced-pressure distillation and concentration and then standing crystallization is conducted; the standing crystallized substance is washed under the state of solvent extraction filtration; and the washed standing crystallized substance is dried until the water content lowers to below 1%, therefore the guanidine derivative creatine hydrochloride product is obtained. The preparation method is used for the additives in foods and various beverages. The preparation method is scientific and reasonable, simple and feasible to operate, stable and reliable in effect, high in product purity, good in quality and low in cost, and causes no pollution without the three wastes.

A creatine amidinohydrolase having the following physicochemical properties: Action: catalyzing the following reaction; creatine + H2O -> sarcosine + urea Optimum temperature: about 40 - 50 DEG C Optimum pH: pH about 8.0 - 9.0 Heat stability: not more than about 50 DEG C (pH 7.5, 30 min) Km value for creatine in a coupling assay using a sarcosine oxidase and a peroxidase: about 3.5 - 10.0 mM Molecular weight: about 43,000 (SDS-PAGE) Isoelectric point: about 3.5, a method for producing said enzyme, comprising culture of microorganism producing said enzyme, a method for the determination of creatine or creatinine in a sample using said enzyme, and a reagent therefor. According to the present invention, a creatine amidinohydrolase having a smaller Km value than that of the conventionally known creatine amidinohydrolase can be produced in an industrially large amount, and can be used as a routine reagent for clinical tests for determining creatine and creatinine in biological samples.

The invention relates to a feed additive for a carp. The feed additive is characterized by being prepared from the following raw materials in parts by weight: 5-8 parts of methionine, 5-8 parts of creatine monohydrate, 8-12 parts of calcium glycinate, 3-6 parts of citric acid, 2-5 parts of riboflavin, 2-5 parts of thiamine, 3-6 parts of zinc gluconate, 3-6 parts of wheat oligopeptides, 8-12 parts of sodium diacetate, 2-5 parts of pyridoxal, 5-8 parts of calcium hydrophosphate, 3-8 parts of calcium pantothenate, 8-12 parts of dimethyl-beta-dimethylpropiothetin, 3-6 parts of inositol, 2-5 parts of vitamin C, 3-6 parts of vitamin E, 1-3 parts of vitamin K, 2-5 parts of yeast beta-glucan, 3-6 parts of guanidinoacetic acid and 5-8 parts of choline chloride. The feed additive has the advantages that the nutrient balance of the carp is relatively well improved, enhancement of the immunity is facilitated and growth and development are promoted.

The invention relates to the field of feed processing and manufacturing, and discloses a feed additive for increasing the lean meat percentage of pork. The feed additive comprises additives A and additives B. The additives A comprise Chinese herbal medicine mixed preparations, betaine, creatine monohydrate, glycocyamine, adenosine triphosphate, mixed vitamins and dopamine; the additives B comprise Chinese herbal medicine mixed preparations, amino acid, creatine monohydrate, carnitine, dihydropyridine, mixed vitamins and dopamine. The feed additive has the advantages that pigs are high in growth speed when the additives A are applied to breeding the pigs with the weights of 20-50 kilograms, the skeletal development of the pigs can be promoted by the additives A, the back-fat thickness can be reduced, and spaces can be provided for muscular synthesis; fat deposition can be accelerated when the additives B are used for breeding pigs heavier than 50 kilograms, and the deposition speeds of proteins can be increased by the additives B by means of constraints on the growth intensity of fat tissues.

The invention relates to a recovery sport nutrition food formula. The food formula includes 40-60% of glucose, 12-18% of L-glutamine, 2-10% of white granulated sugar, banana meal, 2-8% of collagen peptide, 3-5% of creatine monohydrate, 4-10% of trehalose, citric acid, 1-2% of taurine, 0.5-4% of banana flavored essence, 0.3-0.6% of magnesium oxide, potassium chloride, 0.1-0.5% of vitamin C, sucralose, 0.01-0.03% of nicotinamide, 0.004-0.007% of calcium pantothenate, 0.001-0.005% of vitamin B1, 0.001-0.005% of vitamin B2, 0.001-0.005% of vitamin B6 and 0.000005-0.000008% of vitamin B12. The foodformula fully considers that muscle needs sugar (i.e. carbohydrate, an energy substance required after long-time exercise) after exercise and also needs to recover the energy substance, such as the creatine monohydrate, required by short-term explosive exercise.

The invention discloses a creatine instant powder and a preparation method thereof. The creatine instant powder comprises the following components in percentage by mass: 18-40% of creatine monohydrate, 0-40% of instant additive, 0.4%-2% of a suspension stability additive, 20-60% of a spray drying additive and the balance of moisture. The obtained high load creatine instant powder can be rapidly dispersed into water; the concentration of the suspension creatine monohydrate reaches 3-10 times of the saturated solubility thereof; meanwhile, the solution after redissolving can keep stable within 24 hours, and is not layered.

A process for the preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at a temperature from 20 to 150° C. and a pH from 7.0 to 14.0 comprises carrying out the pH adjustment with carbonic acid.

The invention relates to a feed additive for tilapia mossambica. The feed additive is characterized by being prepared from the following raw materials in parts by weight: 5-8 parts of creatine monohydrate, 12-18 parts of calcium phosphate, 2-5 parts of methionine, 6-10 parts of taurine, 2-4 parts of pyridoxamine, 3-6 parts of xanthophylls, 2-5 parts of calcium hydrophosphate, 6-10 parts of glycine betaine, 2-4 parts of sodium glutamate, 8-12 parts of dimethyl-beta-dimethylpropiothetin, 1-3 parts of sodium chloride, 2-4 parts of organic selenium, 5-8 parts of calcium propionate, 2-4 parts of vitamin C, 1-3 parts of vitamin E, 3-6 parts of inositol, 1-3 parts of yeast beta-glucan and 5-10 parts of xylooligosaccharide. The feed additive has relatively good effects of improving nutrient balance of the tilapia mossambica, facilitating enhancement of the immunity and promoting growth and development.

The invention discloses a chemical synthesizing method of creatine monohydrate, and relates to the technical field of processing of medical intermediates. The chemical synthesizing method comprises the following steps of preparing a methylamine solution and a chloroacetic acid solution to react; obtaining a creatine solution, thinning and filtering, washing and drying, so as to obtain a crude product of creatine monohydrate; recrystallizing, so as to obtain the creatine monohydrate. The chemical synthesizing method has the advantages that the technology is simple, and the method is scientific and systematic; by utilizing chloroacetic acid and methylamine to prepare the creatine monohydrate, the cost is low; the prepared creatine monohydrate has high purity and good quality, and obtaining rate is better.

Compositions for neuroprotection and treatment of neurodegeneration and methods of administering same. In particular, the present invention relates to compositions and methods for preventing or reducing neurodegeneration, such as neurodegeneration caused by Huntington's disease, including administering a daily dose of a composition including an effective amount of creatine hydrochloride to a patient in need thereof. The methods of the present invention allow for lower dosages of supplementation as compared to creatine monohydrate while retaining all of the desired biological effects of creatine supplementation.

The invention discloses a high-energy solid beverage used during sports. The high-energy solid beverage comprises the following raw materials in percentage by weight of maltooligosaccharides, cane sugar, oral glucose, sodium chloride, vitamin B6, vitamin B12, vitamin C, creatine monohydrate, glutamine, branched chain amino acids, gamma-aminobutyric acid, fruit and vegetable ferment powder, and bacteria-free water. A preparation method of the high-energy solid beverage comprises the following steps of S1, weighing the raw material components; S2, dissolving the raw material components, and performing stirring to obtain mixed liquid A; S3, adding the branched chain amino acids and the gamma-aminobutyric acid to the mixed liquid, and performing uniform stirring to obtain mixed liquid B for standby application; S4, putting the mixed liquid in gel powder; and S5, subpacking 40g of the granular solid beverage to each of bags so as to obtain the high-energy solid beverage. The prepared high-energy solid beverage is small in size and high in energy, can provide nutrient substances of sugar, electrolyte, vitamins, protein, amino acids and the like which are easy to absorb by human bodies, and can rapidly allay tiredness and restore physical strength.

The invention discloses a grape-flavor composite creatine and a preparation method thereof. The grape-flavor composite creatine is prepared from the following raw materials: 32-36 parts of creatine monohydrate, 12-18 parts of beta-alanine, 13-18 parts of L-arginine, 2-5 parts of 1,6-fructose diphosphate, 5-8 parts of taurine, 0.2-0.5 part of niacin, 0.1-0.3 part of pantothenate, 0.0006-0.009 partof biotin, 7-11 parts of caffeine, 1-4 parts of apple polyphenols, 2-4 parts of grape seed extracts and a blending agent. Good-quality creatine monohydrate and 1,6-fructose diphosphate are selected torapidly synthetize ATP, so as to supply energy and assist in restoring strength; grape seed extracts and apple polyphenols have strong anti-oxidation effects and are capable of effectively eliminating free radicals, dilating blood vessels and conveying nutrients to muscles; beta-alanine is capable of improving the carnosine content of a human body, alleviating fatigue and promoting recovery; taurine is capable of improving the anti-anoxia capability of cardiac muscles and protecting the heart. The grape-flavor composite creatine integrates multiple useful ingredients and is convenient to eatfor people; compared with relevant foods directly eaten, the grape-flavor composite creatine can be better absorbed.

The present invention relates to a meat quality improving feed additive for fattening pigs and a preparation method and an application thereof, and belongs to the field of feed. The feed additive comprises 20-40 parts by weight of creatine monohydrate, 5-25 parts by weight of alpha-lipoic acid, 2-10 parts by weight of carnosine, 2-10 parts by weight of yucca extract and 15-71 parts by weight of carriers. The preparation method comprises the following steps: the carnosine, yuccan extract and carriers are mixed, then the creatine monohydrate and alpha-lipoic acid are added, and the materials are continuously mixed to obtain the finished products. The preparation method is simple and the preparation condition is good in controllability. The prepared feed additive by the method can slow down pH of muscles of the fattening pigs, increases water holding capacity of the muscles, improves meat color and tenderness, can be applied in the feed for the fattening pigs, can significantly improve the meat quality and flavor of the fattening pigs, at the same time improves antioxidant capacity of the fattening pig body and reduces ammonia nitrogen emission.

The invention discloses a special nutrient emulsion containing HMB calcium and whey protein for people with sarcopenia. The nutrient emulsion is prepared by using HMB calcium and whey protein as main raw materials and soybean glycopeptide, gamma-aminobutyric acid, inulin and the like as auxiliary materials, firstly preparing a microcapsule emulsion, then adding creatine monohydrate into the microcapsule emulsion, and conducting homogenizing and sterilizing. The nutritional emulsion is good in emulsion stability, capable of promoting muscle growth and improving muscle strength, good in muscle building effect and especially suitable for people suffering from sarcopenia to use.

Nutritional supplements that reduce the occurrence of and / or prevent and relieve exercise-associated muscle cramps (EAMC) as well as other forms of skeletal muscle cramping are disclosed. The supplements typically comprise Vitamin D3, one or more potassium compounds, creatine monohydrate and magnesium glycinate (and / or other magnesium compounds), and advantageously reduce or eliminate the acute pain, disruptions in the ability to compete, and the associated frustration and disappointment of EAMC and other muscle cramps Aspects of the present invention also provide methods of formulating and using such nutritional supplements for the prevention and relief of muscle cramping.