98 results about "Contagious disease" patented technology

The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.

A device is able to be used to detect an illness and / or symptoms of the illness in a user by utilizing a body fluid detector and / or other devices. The device is also able to determine when additional devices of users come within a specified distance of the device. An alert regarding a diagnosis and / or analysis of the symptoms of the illness is able to sent to a central server, a cloud device or another device to share the diagnosis and / or the analysis of the symptoms of the illness with the additional devices of users.

A proximity network map defines who and what objects have come in contact of each other including location and time. This map selects the list people who have come in contact with known infected people based on contagious disease epidemiology criteria to control its spread, or to prevent radiation poisoning, limit bio-chemicals exposure, etc. These people then undergo testing and quarantine procedures. It monitors hygiene practices and reduces nosocomial infections in hospitals and mitigates the pandemic flu threat by controlling contamination. It controls people interaction, information flow in a high security environment, control crime or gang activities. Each person or object carrying a proximity-sensing unit with unique ID records all units it encountered over a period of time. This information is stored with time stamp in a relational database and transferred to network servers. The databases are then replication throughout via a central web database server for retrieval and analysis.

A contact or proximity network map defines who and what objects have come in contact of each other including location and time. This map selects the list people who have come in contact with known infected people based on contagious disease epidemiology criteria for the purpose of control its spread, or to prevent radiation poisoning, limit bio-chemicals exposure, etc. This selected list of people then undergoes testing and quarantine procedures. It can monitor hygiene practices and reduce nosocomial infections in hospitals and mitigate the pandemic flu threat by controlling spread and control contamination. It controls people interaction, information flow in a high security environment, control crime or gang activities. Each person or object has a proximity-sensing device with unique ID, which is recorded by the encountered units during contact. This information is stored with time stamp in a relational database. It generates contact maps with real time replication of its database via a central web database for retrieval and analysis at any site.

A surveillance system for monitoring outbreak of a contagious disease is disclosed. The system comprises a handheld computing and communication device with a short range ad hoc networking device. Handheld devices carried by persons in contacting with the device carried by a user form an ad hoc communication network at a location. Identities of all devices in the ad hoc network are broadcasted through the network. The user's device receives the identities and stores the received data in a log file. The log file may be sent to a central station after the device receives an authorized signal during an outbreak event of the contagious disease. The device may further include a body temperature automatic measuring system. The user's body temperature trend file may be sent together with the log file.

A cosmetic patch for testing and evaluating a cosmetic product. The patch comprises a top surface colored and textured to match that of a user's features, preferably that of their lips. The reverse side of the patch comprises a weak adhesive surface to temporarily bond to the user's hand, forearm, or other object. When the user deposits a sample of the cosmetic product onto the textured surface of the patch, the user may then compare and evaluate the look of the cosmetic product on their particular features, for example their lips, without having to actually place the cosmetic product on their features and thus prevent the spread of contagious diseases and maintain costs at a minimum for the cosmetics vendor.

A medical isolation gown is disclosed. The gown is to be used by medical personnel treating isolated patients with contagious diseases. The gown comprises slots and pouches that can be used to isolate the worker and his or her instruments from contamination when examining or attending the patient.

The invention relates to a portable specific vomit device for an infectious disease and belongs to the technical field of medical utensils. The portable specific vomit device for the infectious disease comprises a box body. An operation panel is arranged on the front side of the box body; a flushing water box is arranged on the left side of the box body; the lower side of the flush water box is provided with a power supply box; an auxiliary back belt is mounted on the rear side of the box body; a foldable combination hose is mounted on the upper side of the box body; a moth mask accommodatingbox is formed in the right side of the foldable combination hose; a hose fixing clip is cooperated to the upper surface of the foldable combination hose; a sealing mouth mask is mounted on the upper side of the foldable combination hose; a disinfection and sterilizing box is disposed in the box body; a flushing protection plate is placed in the sealing mouth mask; a diversion flushing groove is formed in the right side of the flushing protection plate; and a flushing nozzle is formed in the upper side of the diversion flushing groove. The portable specific vomit device for the infectious disease is simply structured and convenient to use; an infectious disease patient can carry the device, so vomit can be flushed and sealed, and odor of the vomit and saliva splash can be prevented; and patient vomit can be sterilized and disinfected, so bacteria can be fully killed and cross infection can be avoided.

The invention discloses a humanized antibody or antibody fragment for PD-L1 extracellular fragments and application thereof, a nucleotide sequence and a carrier, belongs to the technical field of antibody humanization. The antibody or the antibody fragment comprises a heavy chain and a light chain. Each of the heavy chain and the light chain comprises a variable region. Each variable region comprises complementary determining regions. The complementary determining regions CDR1, CDR2 and CDR3 of the heavy chain are represented by HCDR1, HCDR2 and HCDR3 respectively. The complementary determining regions CDR1, CDR2 and CDR3 of the light chain are represented by LCDR1, LCDR2 and LCDR3 respectively. The antibody or the antibody fragment can improve immunity systems and promote lymphocyte to secrete interleukin-2, and is applied to preparation of diagnostic reagents and anti-tumor, anti-inflammation and anti-contagion drugs.

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation / inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

The invention relates to a Chinese medicinal composition for treating canine highly contagious disease canine distemper and a preparation method thereof. The Chinese medicinal composition mainly comprises indigowoad root, baical skullcap root, golden thread, gypsum, heartleaf houttuynia herb, liquoric root, honeysuckle flower, weeping forsythia and the like, has the effects of improving the immunity of organisms, tonifying middle-jiao and qi and treating the canine distemper, and is mainly used for dogs. The composition keeps the combined effect of the formula of a traditional Chinese medicine for treatment based on syndrome differentiation by combining modern Chinese medicine development technology according to the theory of traditional Chinese medicine. The composition has the effects of resisting viruses, tonifying middle-jiao and qi, and enhancing the immunity of the organisms, treats both symptoms and root causes, is prepared into tablets, has the advantages of convenient administration, high palatability, and definite treatment effect through clinical verification, and is a pollution-free Chinese medicinal composition for treating the canine distemper.

The invention relates to the technical field of veterinary traditional Chinese medicine, in particular to a traditional Chinese medicine for preventing contagious diseases of swine. The traditional Chinese medicine comprises the following raw material medicines in part by weight: 5 parts of reed rhizome, 8 parts of baical skullcap root, 3 parts of atractylis ovata, 15 parts of mung beans, 30 parts of radix isatidis, 10 parts of Chinese yam, 2 parts of peach kernels, 6 parts of rhubarb, 8 parts of evodia rutaecarpa, 12 parts of flower bud of lily magnolia, 15 parts of burdock, and 8 parts of notopterygium root. The traditional Chinese medicine provided by the invention has a remarkable effect for preventing contagious diseases of swine, has no any toxic or side effects, has no obvious side effects on food intake of pigs, has a positive effect on food conversion ratio, is low in dose and cost, and facilitates the increase of income of pig breeders.

The invention provides a traditional Chinese medical composition for treatment of sheep pox. The traditional Chinese medical composition consists of the following components by weight: 1-120 parts of honeysuckle, 1-120 parts of wild chrysanthemum, 1-120 parts of dandelion, 1-120 parts of herba violae, 1-115 parts of radix scutellariae, 1-115 parts of radix isatidis, 1-110 parts of cimicifugae foetidae, 1-115 parts of lithospermum, 1-110 parts of semiaquilegia root and 1-110 parts of liquorice. According to a method of Chinese veterinary dialectical treatment, the honeysuckle, the wild chrysanthemum, the dandelion, the herba violae, the radix scutellariae, the radix isatidis, the cimicifugae foetidae, the lithospermum, the semiaquilegia root and the liquorice are used together, a contagious disease caused by a sheep pox virus, namely sheep pox, can be treated effectively, typical smallpox on the body skin and sometimes the mucosa can be alleviated effectively, and the high mortality caused by fever of ill sheep can be reduced significantly.

The present invention relates to novel compounds of formula (I)that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and / or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

A surveillance system for monitoring outbreak of a contagious disease is disclosed. The system comprises a handheld computing and communication device with a short range ad hoc networking device. Handheld devices carried by persons in contacting with the device carried by a user form an ad hoc communication network at a location. Identities of all devices in the ad hoc network are broadcasted through the network. The user's device receives the identities and stores the received data in a log file. The log file may be sent to a central station after the device receives an authorized signal during an outbreak event of the contagious disease. The device may further include a body temperature automatic measuring system. The user's body temperature trend file may be sent together with the log file.

Classical swine fever virus is a world-wide distributed highly-contagious disease affecting swine. The two main strategies for diseases control are prophylactic vaccination and non-vaccination stamping out policies. Marker vaccines are a promising strategy. Here we report the rational development of a doubly antigenic marker CSFV experimental live attenuated candidate strain vaccine (Flag / T4 virus). Flag / T virus (Flag / T4v) is based in the combination of two Brescia derived recombinant attenuated viruses: RB-C22 and T4. RB-C22v contains a 19mer insertion in the structural glycoprotein E1, while T4v posses mutated CSFV amino acid residues 830 to 834 in the structural glycoprotein E2, deleting the highly conserved epitope recognized by monoclonal antibody (mAb) WH303. Flag / T4 virus contains a positive foreign antigenic marker, due to the insertion of the highly antigenic epitope Flag in the 19mer insertion of E1, as well as a negative antigenic marker, the lack of reactivity with mAb WH303. Immunized with Flag / T4v induced a complete protection against the challenge with virulent strain Brescia both at 3 and 28 days post infection when nasally administered and since the second day post infection when intramuscularly administered. These results constitute an example of rational design of a CSFV antigenically marked LAV.