45 results about "Benzyl-EDTA" patented technology

The invention discloses a preparing method of benzathine penicillin which comprises the following procedures: a, 50 percent to 75 percent of ethanol is added to a raw medicine of the N, N-dibenzyl ethylenediamine diacetate, and is prepared into solvent A; b, 50 percent to 75 percent of ethanol is added to the raw medicine of penicillin G salt, and is prepared into solvent B; c, the pre-applied solvent A is added to the solvent B for stirring, then the residual solvent A is added to the solvent B, thus obtaining nzathine benzylpenicillin suspension; d, filtering and then washing and drying arecarried out on the nzathine benzylpenicillin suspension. The method has the advantages of improving yield coefficient of products, purity quotient and the controllability of particle size, reducing the toxicity of the residual solvent, improving the quality and safety of products and avoiding the harm of methanol to environment and human body at the same time.

The invention discloses a palladium / active carbon catalyst and application thereof in synthesizing N,N'-dibenzylethylenediamine. The palladium / active carbon catalyst is prepared by the following steps of: impregnating active carbon by using aqueous solution of sodium halide, filtering, and washing a filter cake until halogen ions are absent; impregnating the treated active carbon by using aqueoussolution of H2PdCl4; and regulating the pH value of the solution until the solution is alkaline, filtering, washing a filter cake until the filter cake is neutral, and reducing the filter cake by using a reducing agent, and drying the obtained neutral product to obtain the palladium / active carbon catalyst. The palladium / active carbon catalyst has controllable size, most palladium particles in thecatalyst have the particle size of 2 to 5nm, the catalyst is used for synthesizing the N,N'-dibenzylethylenediamine by N,N'-dibenzylidene ethylenediamine through catalytic hydrogenation reduction, and has high activity, selectivity and stability; moreover, the catalyst is easy to prepare, environment-friendly and suitable for industrial application, and precious metal palladium is easy to recover.

The invention discloses a new method for preparing cephapirin benzathine by a one-pot method, relating to the field of chemical drug synthesis. The method comprises the following steps of: taking acetyl bromide 7-ACA as raw materials; in a solvent, in the presence of organic alkali, reacting the acetyl bromide 7-ACA with 4-pyridinethiols to obtain solid cefapirin acid; and then adding the organicalkali in the reaction liquid, dissolving the cefapirin acid as salt, and simultaneously and unnecessarily adding a reductant which is sodium thiosulfate, sodium hydrogensulfite or vitamin C; and then adding a reagent A in the reaction liquid, reacting the cefapirin acid salt with the reagent A at 0-50 DEG C for 0.1-20 hours to obtain the cephapirin benzathine, wherein the reagent A is dibezylethylenediamine diacetate acetate or dibezylethylenediamine diacetate. The method solves the problems that a product is easily decomposed, color is easily deepened in the process of preparing cefapirin sodium salt, and the like. The invention is simplified in steps, easy to operate and suitable for industrialized production, and the quality of the product accord with the quality standard of USP29.

The invention discloses a method for preparing cefnicil dibenzyl ethylenediamine salt, comprising A. acylation reaction: in a pure water system, adding 7-amino-3-(1-methanesulfonyl-1H-tetrazole -5-yl-thiomethyl)-cephem-2-carboxylic acid, add dilute ammonia water to dissolve it, then add a phase transfer catalyst, and dropwise add D-(-)-formylmandelic acid chloride and dilute ammonia water to control pH reaction to obtain an aqueous solution of formyl cefcinib acid; B. Deformylation: the aqueous solution of formyl cefcinid acid obtained in step A is heated to 25-35 ° C, and an acid solution is added to carry out hydrolysis reaction for 3-9 hours, and the hydrolysis is complete Then obtain an aqueous solution of cefcinic acid; C. salify: add N,N-dibenzylethylenediaminediacetic acid solution to the aqueous solution of cefcinic acid in step B, and stir and crystallize to obtain high-purity cefoxinic acid dibenzyl Ethylenediamine salt. The invention realizes emission reduction from the source, environmental protection, simple operation, and greatly reduces the production cost, and produces good economic and social benefits.