41 results about "Artery dissection" patented technology

The invention discloses a covered stent for an aortic dissection surgery, a delivery device and a use method thereof. The stent comprises a main body, wherein the main body decreases progressively from the heart near end with a large diameter to a far end with a small diameter, and the superior border of the middle piece of the main body is a rotary island; a tectorial membrane is arranged except the rotary island, and the two ends of the main body and the rotary island are provided with positioning marks. The delivery device comprises a delivery sheathing canal, a suture and a traction guide wire, wherein the suture is sewn on the outer side surface of the covered stent, and the two side edges of the covered stent at the near end of the left subclavian artery are sewn up by the suture; the stent is closed up to be in a semi-contraction state by the traction guide wire through the suture, and the covered stent is closed up and wrapped in the delivery sheathing canal; the delivery sheathing canal is provided with a steeple, and the far end of the traction guide wire penetrates through the handle of the delivery sheathing canal and is fixed. The covered stent for the aortic dissection surgery is used for a dissecting aneurysm surgery of the lesser curvature side of aortic arch and an interventional minimally invasive surgery of an aortic dissection near the brachiocephalic trunk, so that the trauma of a thoracotomy is avoided, and the athe lumen crevasse occlusion is directly implemented.

A bloodstream dilating device 1 is composed of an elastic member 2 extending in a direction of blood flow in a true lumen 115. The elastic member 2 pushes the inner wall of the true lumen 15 outward to dilate the bloodstream. An aortic dissection treating device includes an obturator and a fixing member for fixing the obturator to the inner layer of an aorta. The obturator is inserted up to the point that it can cover an entry port formed in the aorta. The obturator is deformed along the periphery of the entry port in the inner layer by blood pressure to occlude the entry port.

The invention discloses a plastic covered aortic dissection stent and an aortic dissection stent.The plastic covered aortic dissection stent comprises a tubular covering membrane and multiple annular supports sequentially sewn on the covering membrane in the axial direction and is characterized in that the annular supports on one part of the covering membrane are semi-sewn supports, the semi-sewn supports are provided with non-sewn areas which can be separated from the covering membrane, and the covering membrane corresponding to the internally-bent side of the non-sewn areas breaks away from the semi-sewn supports to be folded internally in a bent state.The semi-sewn supports are distributed at the bent positions after the plastic covered aortic dissection stent is implanted.The number of the semi-sewn supports is at least two sequentially-adjacent circles.When the plastic covered aortic dissection stent is bent, non-sewn areas of every two adjacent annular supports located on the internally-bent side can be overlapped, and the covering membrane in the non-sewn areas is folded towards the inside of the stent to maintain the bent state of the covered stent.

An endoluminal prosthesis for occluding a dissection of an aorta has a tube with a first portion and a second portion. The second portion of the tube comprises a bioaborbable material. The prosthesis also comprises a stent coupled to the tube. The prosthesis is configured for endoluminal placement in the aorta via an artery.

The present invention discloses an aortic image analyzing method and system. The aortic image analyzing method comprises the following steps: step S1: acquiring CTA image data of the aorta; step S2: performing multiplanar reconstruction on the CTA image data; step S3: utilizing an artificial neural network model to identify the aortic lumen, the intima of the interlayer, the crevasse, and the branch vessel in the image obtained through multiplanar reconstruction; step S4: acquiring aortic dissection information according to the result of identification, wherein the aortic dissection information comprises the aortic diameter, the true lumen diameter, the false lumen diameter, the branch vessel angle, the location of the crevasse, and the extension status of the crevasse in the branch vessel. The aortic image analyzing method provided by the invention facilitates achievement of automation and rapidity of diagnosis and measurement of the aortic dissection, which not only can reduce the manual workload, but also can reduce the measurement error and avoid the influence of subjective factors.

The invention discloses application of N6022 in treatment of aortic dissection and aortic aneurysm, and relates to the field of cardiovascular diseases. In mouse models of aortic dissection and aorticaneurysm, dilation of aorta can be inhibited after intravenous injection of the N6022 into tail veins, thereby reducing incidence and mortality of aortic dissection and aortic aneurysm; and moreover,the N6022 is capable of reducing rupture of aortic aneurysm, inhibiting occurrence of hematoma in inner walls of lumen and excessive collagen deposition on vascular walls, maintaining integrity of elastic fibers in the vascular walls, and treating the aortic dissection and the aortic aneurysm. The application of the N6022 in the treatment of the aortic dissection and the aortic aneurysm opens upa new application field of the N6022, and provides a meaningful reference for the prevention and the treatment of the aortic dissection and the aortic aneurysm diseases as well as improvement of vascular lesions.

The invention discloses an intravascular prosthesis. Particularly, the prosthesis comprises i layers of tubular intravascular stents, wherein 2<=i<=8, and the prosthesis is used for treating aortic dissection and arterial aneurysm lesion, particularly ascending aortic aneurysm; the tubular intravascular stents are divided into dense mesh weaved stents and sparse mesh weaved stents, the dense meshweaved stents are large in mesh density, and the sparse mesh weaved stents are small in mesh density; the quantity of the dense mesh weaved stents is m, wherein 1<=m<=4; the quantity of the sparse mesh weaved stents is n, wherein 1<=n<=4, and i=m+n; the dense mesh weaved stents and the sparse mesh weaved stents are coaxially stacked together in the circumferential direction, are used for cooperatively supporting the blood vessel and mutually limit axial stretching or shortening deformation of the stents. By means of the prosthesis in the blood vessel, through a stent interventional operation,the aortic dissection can be effectively treated, particularly the aortic dissection or arterial aneurysm incapable of being subjected to interventional treatment by current clinical medicine.

Medical methods and devices for treating aortic dissections. A catheter-based cutting device permits cutting a septum of acute or chronic aortic dissections, in a retrograde manner. The catheter includes a base section having a central lumen therethrough, two flexible arms extending from a distal end thereof, where each arm has a channel therethrough for a passage of a guide wire. With distal ends of the two flexible arms separated, the two arms form a Y-shape with the base section. With distal ends of the two flexible arms together, the two arms have a longitudinal profile, about a periphery thereof, identical to a longitudinal profile of the base section. A non-mechanically actuated cutting component resides between the two arms in a vicinity of the distal end of the base section. The cutting component faces distally outward between the two arms with the distal ends of the two flexible arms separated.

The invention discloses an aortic dissection vascular stent and a manufacturing method thereof. The aortic dissection vascular stent comprises a stent body and a membrane attached to the outer side of the stent body, the stent body is formed by multiple coils in a spiraling mode, and each coil is formed by multiple waves. The manufacturing method includes the steps that a spatial continuous spiral wave curve is constructed through a spatial cylindrical coordinate system; a three-dimensional model of the stent body is obtained in a scanning mode; an entity model of the stent body is made according to the three-dimensional model; a metal wire is wound around the entity model to obtain the stent body; heat shaping and electropolishing are carried out on the stent body; the membrane is arranged on the outer side of the stent body in an electrospinning or hot-pressing mode. Bending of the vascular stent in the bent lumen is uniformly distributed in the whole vascular stent, so that the fitness of the vascular stent is improved, and the situation that the vascular wall is bent or damaged is avoided. Besides, the vascular stent is specially designed for the aortic dissection and is simple in structure, convenient to operate, appropriate in supporting force and suitable for the pathological characteristics of the aortic dissection.

The invention belongs to the technical field of medicine and discloses an aortic dissection detecting marker and a marker evaluation method. The aortic dissection detecting marker is MMP-9+D-Dimer+ET-1+Calponi. The evaluation method comprises the following steps: performing serological analysis on the selected marker MMP-9+D-Dimer+ET-1+Calponi with ELISA; drawing a ROC (receiver operating characteristic) curve and adopting statistical software SPSS21.0 for analysis. Specificity of three indexes including ET-1, D-Dimer and MMP-9 are higher and are 98.6%, 98.7% and 97.1% respectively, sensitivity of the three indexes are 80.0%, 81.7% and 81.7%, and diagnostic accuracy of the three indexes are also higher and are 86.4%, 87.5% and 87.5%.

The present invention discloses a diagnostic marker for aortic dissection. The diagnostic marker comprises at least one of a protein inhibitor 16 and fibrinogen-like protein 1. The present invention also discloses an application of the diagnostic marker for aortic dissection in diagnosis of the aortic dissection, an application of the diagnostic marker for aortic dissection in production of diagnostic products for diagnosis of the aortic dissection, an application of the diagnostic marker for aortic dissection for distinguishing the aortic dissection from acute coronary syndrome and an application of the diagnostic marker for aortic dissection in production of diagnostic products for distinguishing the aortic dissection from acute coronary syndrome. The diagnostic marker for aortic dissection is screened out by proteomic principles, and verified by a large number of samples. The diagnostic marker for aortic dissection can effectively improve diagnostic rate of the aortic dissection anddiagnostic rate for distinguishing the aortic dissection from acute coronary syndrome.

A device system and method for the treatment of aortic dissections comprising placing a stent in the true lumen and displacing the blood in the false lumen with an inflatable bag.

Medical methods and devices for treating aortic dissections. A catheter-based cutting device permits cutting a septum of acute or chronic aortic dissections, in a retrograde manner. The catheter includes a base section having a central lumen therethrough, two flexible arms extending from a distal end thereof, where each arm has a channel therethrough for a passage of a guide wire. With distal ends of the two flexible arms separated, the two arms form a Y-shape with the base section. With distal ends of the two flexible arms together, the two arms have a longitudinal profile, about a periphery thereof, identical to a longitudinal profile of the base section. A non-mechanically actuated cutting component resides between the two arms in a vicinity of the distal end of the base section. The cutting component faces distally outward between the two arms with the distal ends of the two flexible arms separated.

The invention provides a medicine for treating artery related diseases and application thereof. Specifically, the invention provides application of a compound shown as a formula I in treatment of artery-related diseases, and each group is defined in the specification. Experiments show that the compound in the formula I has remarkable curative effects on the artery diseases such as aneurysm, interwall hematoma and / or arterial dissection.

The invention discloses an aortic dissection surgery risk prediction method based on a lifting tree model. The method comprises the steps of 1, carrying out data preprocessing; complementing data loss parts in the operation records to form a database containing the operation records; step 2, carrying out data mining; processing the data in the database based on the decision tree model; 3, analyzing a result; analyzing a data mining processing result to evaluate the validity of a data mining algorithm; and 4, carrying out knowledge application; and applying the model to data corresponding to the current aortic dissection surgical operation to predict the risk of the current operation. The model has 100% accuracy rate for predicting the death risk after the aortic dissection surgery, compared with other prediction methods, the accuracy is higher, the prediction result can give key factors of death after the aortic dissection surgery, decision basis can be provided for doctors and patients in the future, and a medical policy maker can fully utilize and arrange medical resources.

The invention relates to a method for predicting ICU duration after aortic dissection cardiac surgery. The method comprises the following steps: acquiring ICU data from an ICU database after aortic dissection cardiac surgery, and preprocessing the data; on the basis of a kendall correlation coefficient, carrying out feature extraction on the preprocessed ICU data, and taking features with the correlation coefficient value higher than a preset threshold value; constructing a machine learning model, and training the constructed machine learning model based on the extracted ICU data features; after training is completed, predicting the ICU duration of the patient through real-time ICU data after the aortic dissection cardiac surgery. Through the method, the ICU duration of the patient after the arterial dissection cardiac surgery can be predicted, the mastery degree of the patient and family members on the illness state and the recovery process is improved; meanwhile, a powerful support can be provided for medical personnel to prepare a medical plan.

The invention belongs to the field of medical instruments and relates to a device for being implanted in the abnormal bulging position of an arterial canal wall. The device comprises a bag capable of being implanted in the abnormal bulging position of the arterial canal wall and bulging, when the bag bulges, the bag has 3D modeling anatomy three-dimensional morphological features conforming to the implanting position, and therefore blood cannot flow into the abnormal bulging position of the arterial canal wall from an arterial canal. According to the device, the blood cannot flow into the abnormal bulging position of the arterial canal wall from the arterial canal, blood flow smoothness in the tumor-carrying arterial canal is kept, blood flow smoothness of branch blood vessels of the arterial canal is kept, thus, the device can be used for treating the diseases such as intracranial aneurysms, visceral aneurysms, false aneurysms, aortic aneurysms, artery dissection and aortic dissection, and a new way for aortic disease interventional therapy is expected to be opened up.

The invention relates to a double-lumen radiography catheter, which comprises a catheter body and a Y-shaped connector which is arranged at the distal end of the catheter body, wherein the catheter body comprises a first lumen and a second lumen; a straight branch of the Y-shaped connector communicates with the first lumen, and a side branch of the Y-shaped connector communicates with the second lumen; a hemostasis valve is arranged on at least one of the straight branch and the side branch of the Y-shaped connector; and the hemostasis valve is provided with a contrast medium inlet and a guidewire inlet. The radiography catheter provided by the invention is simple in structure and simple to operate; and a true lumen of artery dissection can be found out rapidly, so that operating time issaved and operative risks are reduced.

The invention discloses an aortic dissection vascular stent and a manufacturing method thereof. The aortic dissection vascular stent comprises a stent body and a membrane attached to the outer side of the stent body, the stent body is formed by multiple coils in a spiraling mode, and each coil is formed by multiple waves. The manufacturing method includes the steps that a spatial continuous spiral wave curve is constructed through a spatial cylindrical coordinate system; a three-dimensional model of the stent body is obtained in a scanning mode; an entity model of the stent body is made according to the three-dimensional model; a metal wire is wound around the entity model to obtain the stent body; heat shaping and electropolishing are carried out on the stent body; the membrane is arranged on the outer side of the stent body in an electrospinning or hot-pressing mode. Bending of the vascular stent in the bent lumen is uniformly distributed in the whole vascular stent, so that the fitness of the vascular stent is improved, and the situation that the vascular wall is bent or damaged is avoided. Besides, the vascular stent is specially designed for the aortic dissection and is simple in structure, convenient to operate, appropriate in supporting force and suitable for the pathological characteristics of the aortic dissection.

The invention provides application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm. The R-ketorolac is orally taken to inhibit pathological expansion of aorta and reduce the occurrence rate and death rate of the aortic dissection and aortic aneurysm; and the R-ketorolac can inhibit the occurrence of vascular wall inflammatory reaction, reduce rupture of aortic aneurysm bodies, inhibit the occurrence of hematoma in the inner wall of a lumen, maintain the integrity of vascular wall elastic fibers and treat the aortic dissection and aortic aneurysm. The invention develops a new application field of the R-ketorolac, and provides a significant reference for preventing and treating aortic dissection and aortic aneurysm diseases and improving vascular lesion conditions.

The invention discloses a compound preparation containing benidipine hydrochloride and metoprolol tartrate and an application thereof; for the preparation, the benidipine hydrochloride and the metoprolol tartrate are taken as active pharmaceutical ingredients. The compound pressure-reducing preparation adopts drug combination and is good in efficacy, less in side effects and high in performance-price ratio; the compound preparation is taken once per day, the administration is convenient and the drug compliance of a patient can be improved. The preparation can be prepared into oral formulations in different forms, thereby realizing synergic and complementary action of drugs and enhancing the treatment effect of the compound preparation. The compound preparation has significant effects for treating hypertension and can also be used for treating angina pectoris, myocardial infarction and arrhythmia, as well as hypertrophic cardiomyopathy, aortic dissection, hyperthyroidism, cardiac neurosis, chronic stable heart failure and other symptoms. The compound preparation is low in price, simple to prepare and convenient to popularize and apply.

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

The invention provides a medicine for treating artery-related diseases and an application thereof. Specifically, the invention provides an application of the compound shown in the formula I in treating artery related diseases. Experiments show that the compound shown in the formula I has a remarkable curative effect on arterial lesions such as aneurysm, interwall hematoma and / or arterial dissection.

A method of determining a risk probability of vertebral artery dissection (VAD) in a patient, including receiving medical image information of the patient and clinical report information of the patient; extracting at least one biomarker corresponding to a vertebral artery segment included in the medical image information; extracting patient history information from the clinical report information; and determining the risk probability of VAD using a deep learning classification model based on the extracted at least one biomarker and the extracted patient history information.

A system for treating aortic dissection includes a sinotubular junction magnetic array having a first plurality of magnetic elements, a counter-magnetic array having a second plurality of magnetic elements, and an ascending aortic stent graft comprising a third plurality of magnetic elements. A method for treating aortic dissection includes the steps of positioning a sinotubular junction magnetic array at the sinotubular junction, advancing counter magnetic constructs from the femoral vein and positioning them in the right atrium, expanding the sinotubular junction ring at a target position, advancing the counter magnetic array to form an at least partial circumferential seal, and advancing and positioning an ascending magnetic graft within an interior of the sinotubular junction magnetic array. A system for treating aortic dissection, a fixation device for anchoring an ascending aortic stent graft, and a transcatheter device for treating aortic dissection are also described.

The invention discloses pharmaceutical application of Sonidegib in treatment of aortic dissection, and relates to the field of cardiovascular systems. After Sonidegib is administered to aortic dissection model mice through intragastric administration, aortic pathological expansion can be effectively inhibited, the death rate and the occurrence rate of aortic dissection can be reduced, and meanwhile, aortic vascular endothelial cell connection injury of the aortic dissection mice can be relieved; and human umbilical vein endothelial cells (HUVECs) are stimulated by angiotensin 2, and after Sonidegib is given to the HUVECs, the connection injury of the HUVECs can be inhibited.

The present invention relates to the use of polymer salvianolic acid in the preparation of drugs for inhibiting the occurrence of aortic aneurysm or aortic dissection; and a pharmaceutical composition, including polymer salvianolic acid as a pharmaceutically active substance, and related required adjuvants, etc., the pharmaceutical composition can be used to inhibit the occurrence of aortic aneurysm or aortic dissection. The multimer salvianolic acid is dimer salvianolic acid, trimer salvianolic acid or tetramer salvianolic acid, wherein, the dimer salvianolic acid is rosmarinic acid, and the trimer The body salvianolic acid is salvianolic acid C, shikonian acid or salvianolic acid A, and the tetramer salvianolic acid is salvianolic acid B.