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Application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm

A technology for aortic dissection and aortic aneurysm, applied in the application field of R-ketorolac in the prevention and treatment of aortic dissection and aortic aneurysm, to inhibit the occurrence of hematoma, prevent and treat aortic dissection and aortic aneurysm diseases, improve Effect of Vascular Condition

Active Publication Date: 2021-11-30
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether R-ketorolac can improve aortic dissection and aortic aneurysm and its mechanism has not yet been studied or reported

Method used

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  • Application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm
  • Application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm
  • Application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1: The inhibitory effect of R-ketorolac on the formation and rupture of aortic aneurysm

[0016] In order to explore the effect of R-ketorolac on tumor formation and rupture in aortic aneurysm model mice, we selected SPF grade 8-week-old male ApoE- / - mice (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.), Randomly divided into four groups: placebo control group (Saline+placebo), administration control group (Saline+ 2mg / kg / day R-ketorolac), aortic aneurysm model placebo control group (AngII+placebo) and aortic aneurysm model Administration group (AngII+2mg / kg / day R-ketorolac). That is, when the mice were 8 weeks old, an osmotic micropump (Alzet, USA, 2004 model) was subcutaneously implanted on the back, the control group was given normal saline, the aortic aneurysm model placebo control group and the aortic aneurysm model administration group were given Ang II (1000ng / kg / min), and oral placebo or R-ketorolac (2mg / kg / day). The deat...

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Abstract

The invention provides application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm. The R-ketorolac is orally taken to inhibit pathological expansion of aorta and reduce the occurrence rate and death rate of the aortic dissection and aortic aneurysm; and the R-ketorolac can inhibit the occurrence of vascular wall inflammatory reaction, reduce rupture of aortic aneurysm bodies, inhibit the occurrence of hematoma in the inner wall of a lumen, maintain the integrity of vascular wall elastic fibers and treat the aortic dissection and aortic aneurysm. The invention develops a new application field of the R-ketorolac, and provides a significant reference for preventing and treating aortic dissection and aortic aneurysm diseases and improving vascular lesion conditions.

Description

technical field [0001] The invention belongs to the technical field of aortic dissection and aortic aneurysm treatment, and specifically relates to the application of R-ketorolac in preventing and treating aortic dissection and aortic aneurysm. Background technique [0002] Aortic aneurysm and aortic dissection (AAD) are one of the cardiovascular diseases that seriously endanger human health. Aortic aneurysm is a permanent and irreversible local expansion of the aorta. Bleeding within the arterial wall, leading to separation of the aortic wall, resulting in a life-threatening condition. At the population level, ruptured aortic aneurysm is the leading cause of death. Aortic dissection is most common in people aged 65-75, with an incidence of 35 per 100,000 per year. Early aortic aneurysms usually have no obvious symptoms. When the aneurysm ruptures, the typical symptoms are sudden onset of severe chest pain or back pain without evidence of myocardial ischemia. In severe c...

Claims

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Application Information

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IPC IPC(8): A61K31/407A61P9/00A61P9/14A61P35/00
CPCA61K31/407A61P9/00A61P9/14A61P35/00
Inventor 季勇张昊张艳张旭红严科韩艺谢利平
Owner NANJING MEDICAL UNIV
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