121 results about "2-Furoic acid" patented technology

Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.

The present invention relates to antifungal composition with two or more active components and its application in medicine, cosmetics and sanitary articles. The externally applied antifungal composition butenafine, butenafine hydrochloride or ketoconazole in 0.1-10 wt%, and mometasone furoate in 0.001-10 wt%, except substrate. Animal test shows that the antifungal composition has obvious synergistic effect in resisting Trichophyton mentagrophytes infection.

Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.

The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.

The invention discloses a composite fluorine removing agent for removing high-concentration fluorine-containing wastewater and an application method thereof, which belong to the field of sewage treatment in environment protection. The composite fluorine removing agent is prepared by compounding polyhydroxyl or polycarboxyl compounds and inorganic matters according to a certain proportion, wherein the polyhydroxyl or polycarboxyl compounds include one or more than two of trifluoromethanesulfonic anhydride, caprylyl chloride, 1R-(-)-camphorsulfonic acid, 3-furoic acid, pentanoyl chloride, and butanetetracarboxylic acid; and the inorganic matters include two or more than two of calcium salt, magnesium salt, phosphate, and ferric salt. The composite fluorine removing agent is added into the high-concentration fluorine-containing wastewater in a weight ratio of 1:100 to 1:1000 according to the concentration of fluorine in the wastewater; the pH value of the wastewater is adjusted to 9.0-11.0 with sodium hydroxide; and the wastewater is stirred for 15-30min, so that the yielding water can meet the national emission standard I. The composite fluorine removing agent and the application method thereof disclosed by the invention have the characteristics of simple technological process, smaller dosage of chemical agent, lower running expense, no sludge, high removal rate, and the like; and the removal rate can reach above 99.9%.

The invention relates to fungal cells for the production of FDCA. The fungal cell is genetically modified to have at least one of a) a genetic modification that confers to or increases in the cell theability to oxidize 5-hydroxymethyl-2-furancarboxylic acid to 5-formyl-2-furoic acid; and, b) a genetic modification that reduces catabolism of 2,5-furandicarboxylic acid in the cell. The fungal cellcan further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furandicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA.

The invention discloses mometasone furoate emulsifiable paste and a preparation method thereof, and belongs to the technical field of external pharmaceutical preparations. The mometasone furoate emulsifiable paste comprises the following components in parts by weight: 0.5 to 2 parts of mometasone furoate, 0.2 to 0.4 part of acid, 75 to 150 parts of an oil phase regulator, 30 to 50 parts of a consistency regulator, 60 to 100 parts of a humectant, 80 to 120 parts of a co-emulsifier, 60 to 90 parts of a cosolvent, 1 to 3 parts of a whitening agent, 30 to 50 parts of an emulsifier, 0.3 to 1 part of a preservative and 495 to 605 parts of water. The preparation method disclosed by the invention is advanced in process, and simple and easy to operate, and the prepared mometasone furoate emulsifiable paste is reduced in impurity content, high in yield and good in stability.

The invention relates to a method for preparing furoic acid by oxidizing furfural on a micro-channel reactor. The method comprises the following steps: (1) conveying furfural and a NaOH solution intoa micro-channel reactor by a plunger pump, introducing air into the micro-channel reactor, and obtaining a reaction solution from the outlet of the reactor; (2) performing acidification, crystal growing, filtering and ice water leaching to obtain a furoic acid wet product; and (3) performing vacuum drying to obtain solid furoic acid. According to the invention, by utilizing the micro-channel reactor, the reaction heat can be well controlled, the continuous production of furoic acid is realized, the reaction speed is high, the residence time is short, the purity of the prepared furoic acid is more than 99.5%, and the yield is more than 97.6%.

The invention provides a preparation method of furoic acid, and the method comprises the following steps of: under the condition of air and / or oxygen, contacting an aqueous solution of furfural with a catalyst for catalytic oxidation reaction to prepare furoic acid, wherein the catalyst is obtained by the following steps of: mixing a carrier, an alkaline nitrogen-containing compound and an active component precursor and placing the mixture in a solvent, performing heating under a water bath condition and carrying out reflux stirring treatment; sequentially carrying out drying treatment and roasting reduction treatment on the mixture subjected to the reflux stirring treatment to obtain the catalyst; wherein the active component precursor is selected from one or more of rhodium chloride, palladium chloride, chloroplatinic acid and ruthenium chloride, and the carrier is selected from one or more of activated carbon, graphite, fullerene and graphene oxide. The catalyst adopted by the method is high in activity, the product yield is high, the reaction does not need to be carried out in an alkaline environment, the reaction process is environment-friendly, the product is easy to separate, and the problem of complicated subsequent acid treatment in the traditional furoic acid preparation process is solved.

The invention relates to 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate as well as an extraction method and medicine application thereof, and belongs to a new compound and medicine application thereof. Ginseng stem and leaves and artemisias tolonifera are taken as raw materials and are subjected to pulverization, high temperature high pressure treatment, drying, chloroform extraction, silica-gel column chromatography and recrystallization, and then the 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate is obtained. The 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate is applied to preparation of medicines for treating the hypertension.

The invention discloses a method for co-producing epoxypropane and furoic acid. According to the method, propylene and furfural serve as raw materials, oxygen serves as an oxidizing agent, organic solvent is added, metal phthalocyanine or metallloporphyrin compound serves as a catalyst, and catalytic reaction is controlled to be performed under the conditions that the reaction temperature is 30-140 DEG C and the reaction pressure is 0.1-3.0 MPa to obtain the epoxypropane and the furoic acid. The method has the advantages of being mild in reaction condition, high in efficiency, high in selectivity of the epoxypropane and the furoic acid, simple in technology and the like.

The present invention relates to a method for preparing furoic acid by oxidation of furfural on a microchannel reactor. The reaction solution is obtained at the outlet; (2) Acidification, crystal growth, filtration and rinsing with ice water are performed to obtain a wet product of furoic acid; (3) vacuum drying is performed to obtain solid furoic acid. The present invention uses a microchannel reactor to better control the heat of reaction and realize the continuous production of furoic acid, with fast reaction speed and short residence time, the purity of the prepared furoic acid is 99.5% and above, and the yield is 97.6% and above .