17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate and extraction method and medicine application thereof

A technology of cyclopentane furoate and polyhydrophenanthrene, which can be used in drug combinations, pharmaceutical formulations, steroids, etc., can solve problems such as kidney damage, abnormal metabolism, and cardiac depression, and achieve significant curative effects.

Inactive Publication Date: 2015-03-11
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have certain side effects, such as cardiac depression, metabolic abnormalities, kidney damage, etc.

Method used

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  • 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate and extraction method and medicine application thereof
  • 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate and extraction method and medicine application thereof
  • 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate and extraction method and medicine application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Take 200g of ginseng stems and leaves and 100g of Artemisia broadleaf, cut them into pieces, add 300mL of water, process under high temperature and high pressure for 8 hours, and filter to obtain the filtrate and medicinal residues respectively; take the above filtrate, extract with chloroform three times, add 300mL of chloroform each time, and combine the chloroform extract; take the above-mentioned dregs, extract 3 times with chloroform, add 300mL chloroform each time, and combine the chloroform extract; combine the above-mentioned chloroform extract and chloroform extract, recover the solvent, and obtain the chloroform extract; take the above-mentioned chloroform extract The substance was subjected to repeated column chromatography with silica gel as the adsorbent, and gradient elution was performed with petroleum ether-acetone (50:1~1:1), and the eluate from part A of cyclopentanediphenanthrene furoate was collected and recovered. Solvent to obtain the crude product ...

Embodiment 2

[0048] Take 400g of ginseng stems and leaves and 100g of Artemisia broadleaf, cut them into pieces, add 500mL of water, treat with high temperature and high pressure for 6 hours, and filter to obtain the filtrate and medicinal residues respectively; take the above filtrate and extract once with 500mL of chloroform to obtain the chloroform extract; The above medicinal residues were leached once with 500mL chloroform to obtain a chloroform extract; the above-mentioned chloroform extract and chloroform extract were combined, and the solvent was recovered to obtain a chloroform extract; Chromatography, using petroleum ether-acetone (50:1~1:1) for gradient elution, collecting the eluate from part A of cyclopentanefuroate and polyhydrophenanthrene furoate, and recovering the solvent to obtain cyclopentanefuroate The crude product of phenanthrene ester A was recrystallized from petroleum ether-acetone to obtain cyclopentanedohydrophenanthrene furoate A.

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Abstract

The invention relates to 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate as well as an extraction method and medicine application thereof, and belongs to a new compound and medicine application thereof. Ginseng stem and leaves and artemisias tolonifera are taken as raw materials and are subjected to pulverization, high temperature high pressure treatment, drying, chloroform extraction, silica-gel column chromatography and recrystallization, and then the 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate is obtained. The 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl furan-3-carboxylate is applied to preparation of medicines for treating the hypertension.

Description

technical field [0001] The present invention relates to a kind of cyclopentanedohydrophenanthrene furoate A, its extraction method and its medicinal application. It belongs to new compounds and their medicinal uses. Background technique [0002] ginseng Panax giseng C.A.Mey. is a plant of the genus Panax genus Araliaceae. in, Panax The meaning of Greek is "panacea", and the Manchu pronunciation of ginseng is "Orhouda", which means "king of herbs". As a traditional medicinal material, it has a history of thousands of years and is widely used in countries all over the world. Ginseng greatly invigorates the vital energy, restores the veins and strengthens the spleen, nourishes the spleen and lungs, promotes fluid production, and calms the nerves. [0003] Artemisia broadleaf ( Artemisias tolonifera ), also known as Artemisia tianmu, belongs to the genus Artemisia of Asteraceae ( Artemisia ) perennial herbaceous plants. The stems are erect, hollow, and the leaves are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J17/00A61K31/58A61P9/12
CPCA61K31/58C07J17/00
Inventor 赵岩张连学唐国胜郜玉钢许永华蔡恩博刘双利杨鹤刘学周
Owner JILIN AGRICULTURAL UNIV
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