Mometasone furoate emulsifiable paste and preparation method thereof
A technology of mometasone furoate cream and mometasone cream, which is applied in directions such as ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of waste, low yield, low yield and the like, and achieves good stability, The effect of high yield and reduced impurity content
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Embodiment 1-5
[0057] Wherein, the formula of embodiment 1-5 is as shown in table 1:
[0058] Table 1.
[0059]
[0060] Embodiment 1-5 is all prepared according to the following steps:
[0061] Step 1, the preparation of the oil phase: weigh cetostearyl alcohol, light liquid paraffin, glyceryl mono- and distearate by weight and place them in the oil phase heating tank, open the interlayer steam and heat to 85°C, stir and dissolve, 85 ℃ heat preservation standby;
[0062] Step 2, preparation of the water phase: weigh purified water, glycerin, and polysorbate 80, which is half of the prescription amount, and place it in the water phase heating tank, turn on the interlayer steam and heat to 85°C, stir evenly, and keep warm at 85°C spare;
[0063] Step 3, the preparation of phosphoric acid solution: take phosphoric acid by weight, add purified water to make 1.0% phosphoric acid solution, set aside;
[0064] Step 4, the preparation of the main drug solution: take the remaining part of pol...
Embodiment 6
[0071] Different from Example 1, step 5 is specifically:
[0072] a Pump the water phase into a vacuum emulsifier, add titanium dioxide, stir to make it evenly dispersed, and keep it warm at 85°C for later use;
[0073] b. Pump the oil phase into the vacuum emulsifier, start the homogenizer (2550rpm, 10 minutes), and at the same time stir slowly (80rpm, 10 minutes) to make an emulsion-type matrix, cool down to 50°C-55°C, and keep warm;
[0074] c. Pump the 1.0% phosphoric acid solution into the vacuum emulsifier, start the homogenizer (2550rpm, 5 minutes), and at the same time stir slowly (80rpm, 5 minutes), keep warm at 50°C-55°C;
[0075] d Pump the main ingredient solution into the vacuum emulsifier, stir evenly, start the homogenizer (2550rpm, 5 minutes), and at the same time stir slowly (80rpm, 10 minutes), cool to below 50°C and stir out the paste.
[0076] It is found in the experiment that at this homogenization speed, the paste is viscous, has no fluidity, and is dif...
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