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Skin percutaneous absorption drug of adjuvant-containing mometasone furoate and adjuvant-containing water

A technology of mometasone furoate and pharmaceutical excipients, which is used in medical preparations containing active ingredients, skin diseases, drug combinations, etc., can solve the problem of inability to guarantee the Ostwald ripening of particulate suspensions, unstable particles, etc. problems, to ensure the stability of the suspension and reduce waste.

Inactive Publication Date: 2012-07-11
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems to be solved in pharmacy, but no matter whether by adding excipients or improving the particle structure, there is no guarantee that microparticle suspensions will not appear Osmos during storage. Twald ripening, especially with multiple uses of dermal suspensions, is more likely to occur

Method used

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  • Skin percutaneous absorption drug of adjuvant-containing mometasone furoate and adjuvant-containing water
  • Skin percutaneous absorption drug of adjuvant-containing mometasone furoate and adjuvant-containing water
  • Skin percutaneous absorption drug of adjuvant-containing mometasone furoate and adjuvant-containing water

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preparation example Construction

[0041] 1. Preparation of drug particles for transdermal absorption

[0042] The capsules packed with the drug microparticles obtained in Examples 1 to 10 are plant capsules, and the capsules are sealed and packaged with aluminum foil blisters after packing. The water containing auxiliary materials obtained in Examples 11 and 12 is sealed and packed in ampoules.

Embodiment 1

[0044] Dissolve 0.2g mometasone furoate in ethanol, filter, sterilize, spray-dry the filtrate, micronize the particle size to 3μm, mix with 1.5g crystalline lactose with a particle size of 30μm, pass through a 200-mesh sieve for 3 times and mix After uniformity, it is divided into No. 2 capsules, and each capsule contains 2 mg of mometasone furoate. Electron microscope observation shows that the drug particles are spherical.

[0045] The process conditions are: the inlet temperature is 100°C, the outlet temperature is 70°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0047] Dissolve 1 g of mometasone furoate in ethanol, filter, spray-dry the filtrate, micronize it to a particle size of 3 μm, mix it with 15 g of crystalline lactose with a particle size of 30 μm, mix it with a 200-mesh sieve for 3 times, and then sterilize it. Packed into No. 2 capsules, each capsule contains 1mg of mometasone furoate. Electron microscope observation shows that the particles are spherical.

[0048] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention relates to a skin percutaneous absorption drug of adjuvant-containing mometasone furoate and adjuvant-containing water. The skin percutaneous absorption drug comprises mometasone furoate and water, wherein the packing manner of the mometasone furoate adopts the individual packing, the mometasone furoate contains one or a plurality of solid medicine adjuvants, and is insoluble, the D90 particle size is 0.1-10 mum, the packing manner of the water adopts the individual packing, and the water contains one or a plurality of soluble medicinal adjuvants.

Description

Technical field: [0001] The invention relates to a medicine for skin, which is composed of separately packaged mometasone furoate containing one or several skin medicine auxiliary materials and separately packaged water containing the auxiliary materials. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery system (transdermal thrapeutic systems, transdermal dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/10A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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