The invention discloses a polytetrafluoroethylene (PTFE) base electrothermal thick film, comprising the following materials according to percentage by weight: 20-30% of flake graphite, 8-15% of acetylene black, 5-8% of carbon fiber powder, 4-6% of short carbon fiber, 5-8% of nickel powder, 5-8% of silver powder, 1-3% of manganese dioxide, 1-3% of iron sesquioxide, 1-3% of carbon black dispersant, 20-25% of PTFE dispersion liquid and 10-25% of PTFE diluent. The invention also discloses a manufacturing method of the PTFE base thick film, comprising the steps of grinding and uniformly mixing the flake graphite, the acetylene black, the carbon fiber powder, the short carbon fiber, the nickel powder, the silver powder, the manganese dioxide and the iron sesquioxide according to the proportion, mixing and ultrasonically dispersing the mixture, the carbon black dispersant, the PTFE dispersion liquid and the PTFE diluent according to the proportion to prepare a electrothermal thick film paste, and drying and sintering the electrothermal thick film paste, after a through printing process so as to manufacture the PTFE base electrothermal thick film. The manufacturing method provided by the invention is applicable to high-voltage electrothermal equipment, good in stability and using effect, and is not demoulded.