The invention discloses an automatic instillation device which comprises a pipeline, wherein one end of the pipeline is used for being connected with a liquid storage bag, the other end of the pipeline is used for being connected with an instillation needle, and a liquid supply device used for supplying liquid to the pipeline in a mode of variable volume and a point pressure drive device used for driving the liquid supplying device to be changed in volume are arranged on the pipeline. According to the invention, through the arranged liquid supply device and the point pressure drive device, continuous drops can be automatically provided and are instilled into a human body through the pipeline and the instillation needle, therefore, the liquid storage bag is not needed to be suspended overhead, and a patient is favorably moved. A safety check valve is provided with a safety valve seat, and when the liquid storage bag is pressed, the matching of a valve plug and the safety valve seat in the safety check valve can prevent more liquid from entering the pipeline. The existing liquid storage bag can be adopted, during replacement, the pipeline and the liquid supply pipeline are only discarded, and residual parts can be recycled, therefore, the automatic instillation device is beneficial to resource saving, is simple and reliable in mechanical structure, and is low in manufacture cost.